Fluvastatin
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Development and validation of a GC-FID assay for determination of fluvastatin in pharmaceutical preparations
A gas chromatographic method has been developed for the assay of fluvastatin sodium (FLU). FLU was silylated with N,O-bis(trimethylsilyl)trifluoroacetamide-1% trimethylchlorosilane at 90 ºC for 30 min and analysed in a DB-1 column by capillary gas chromatograph with a flame ionization detector. The method was validated. The assay was linear over the concent
Química Nova. Publicado em: 2009
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2. Influência da inalação de metanol na farmacocinética enantiosseletiva da fluvastatina em ratos / Inalation influence of methanol on the pharmacokinetics enantiosselective of fluvastatin in rats.
Dislipidemia is one of the main causes of cardiovascular illness and very frequent in the adults population. Fluvastatin, a racemic mixture of the (-)-3S,5R and (+)-3R,5S enantiomers, has been shown to be a potent competitive inhibitor of HMGCoA reductase used in the hypercholesterolemia treatment and with elimination in the man essentially dependent of the
Publicado em: 2008
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3. Estatinas hipolipêmicas e novas tendências terapêuticas
Statins are the most used drugs for the treatment of hyperlipidemia in primary and secondary prevention, with the aim of decreasing the levels of plasmatic cholesterol- lipoproteins. Owing to their structural similarity to the substrate HMG-CoA (3-hydroxy-3-methylglutaryl-CoA), they inhibit the HMG-CoA reductase enzyme, disrupting the cholesterol biosynthesi
Química Nova. Publicado em: 2007-04
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4. Efeito de exercÃcio fÃsico e estatinas no perfil lipÃdico e na funÃÃo muscular em ratos dislipidÃmicos
Statins are used to treat dislipidemias with great tolerance, however, several side effects can occur, specially myopathies. The regular practice of physical exercise (PE) produce beneficial alteration in the lipidic profile, however can generate muscle injuries. OBJECTIVE -To evaluate the effect of PE in the lipidic profile; the efficacy of the assocciation
Publicado em: 2007
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5. Comparison of the effect of two HMG CoA reductase inhibitors on LDL susceptibility to oxidation
OBJECTIVE: To study the differences between fluvastatin and pravastatin regarding LDL susceptibility to oxidation, plasma levels of total cholesterol (TC), HDL-C, LDL-C and triglycerides (TG) in hypercholesterolemic patients with established coronary heart disease (CHD). METHODS: A double-blind randomized parallel study was conducted that included 41 hyperch
Arquivos Brasileiros de Cardiologia. Publicado em: 2003-02
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6. In vitro activity of fluvastatin, a cholesterol-lowering agent, and synergy with flucanazole and itraconazole against Candida species and Cryptococcus neoformans.
Fluvastatin, a cholesterol-lowering drug, exhibited minimal activity (MICs of 64 to >128 microg/ml) against Candida species and Cryptococcus neoformans. When fluvastatin was combined with fluconazole or itraconazole, both synergistic and additive effects were noted (fractional inhibitory concentration indices of < or = 0.156 to 0.625; fractional lethal conce
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7. No significant effect of ABCB1 haplotypes on the pharmacokinetics of fluvastatin, pravastatin, lovastatin, and rosuvastatin
Blackwell Science Inc.
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8. Fluvastatin inhibits expression of the chemokine MDC/CCL22 induced by interferon-γ in HaCaT cells, a human keratinocyte cell line
Blackwell Publishing Ltd.
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9. Fluvastatin in the therapy of acute coronary syndrome: Rationale and design of a multicenter, randomized, double-blind, placebo-controlled trial (The FACS Trial)[ISRCTN81331696]
BioMed Central.
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10. Novel Biodegradable Polyester Poly(Propylene Succinate): Synthesis and Application in the Preparation of Solid Dispersions and Nanoparticles of a Water-Soluble Drug
Poly(propylene succinate) (PPSu) polymers of average molecular weights from 2,800 to 13,100 g/mol were synthesized and characterized with regard to crystallinity, thermal properties, and cytocompatibility. Higher molecular weight samples exhibited lower degree of crystallinity and melted at lower temperatures. Melting of the polymer appeared to begin at 38�
Springer US.
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11. Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila
In Drosophila, locomotor activity is sexually dimorphic and the brain area controlling this dimorphism has been mapped. The neurons of the pars intercerebralis (PI) have been suggested to participate in such differences between males and females. However, the precise physical nature of the dimorphism, the identity of the PI neurons involved, and the nature o
National Academy of Sciences.
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12. Impact of OATP transporters on pharmacokinetics
Membrane transporters are now recognized as important determinants of the transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a family of influx transporters expressed in various tissues important for pharmacokinetics. Of the 11 human OATP transporters, OATP1B1, OATP1B3 and OATP2B1 are expressed on the sinusoidal membrane of h
Blackwell Publishing Ltd.