Genome Mining
Mostrando 1-12 de 65 artigos, teses e dissertações.
-
1. Unveiling the Bacterial Sesquiterpenome of Streptomyces sp. CBMAI 2042 Discloses Cyclases with Versatile Performances
Terpenes are the most abundant class of natural product that exist in nature. They possess a myriad of industrial applications including pharmaceutical, perfumery and flavors, bulk chemicals, and fuel. Intriguingly, until today, the vast majority of characterized terpenoids have been isolated from plants and fungi, and only in recent years bacteria were foun
Journal of the Brazilian Chemical Society. Publicado em: 2022
-
2. Discovery and characterization of SSR markers in Eugenia uniflora L. (Myrtaceae) using low coverage genome sequencing
Abstract: Eugenia uniflora L. (Myrtaceae) is a tree species widely distributed in South America suffering the effects of the exploitation of natural populations. In this study, we employed low coverage sequencing of the E. uniflora genome for mining of SSR markers. The de novo assembly generated 2,601 contigs with an average length of 1139 bp and spans 3.15
An. Acad. Bras. Ciênc.. Publicado em: 08/04/2019
-
3. Heterologous Expression of a Putative ClpC Chaperone Gene Leads to Induction of a Host Metabolite
Genome mining provides exciting opportunities for the discovery of natural products. However, in contrast to traditional bioassay-guided approaches, challenges of genome mining include poor or no expression of biosynthetic gene clusters (BGCs). Additionally, given that thousands of BGCs are now available through extensive genome sequencing, how does one sele
J. Braz. Chem. Soc.. Publicado em: 2019-03
-
4. Gene Deletion Leads to Improved Valinomycin Production by Streptomyces sp. CBMAI 2042
The genus Streptomyces represents one of the largest producers of molecules with antibiotic activity. The whole genome sequencing of the endophytic microorganism Streptomyces sp. CBMAI 2042 revealed 35 gene clusters encoding for secondary metabolism including 3 non-ribosomal peptide synthetases (NRPS) and 7 NRPS-hybrids. Combining genome mining and cultivati
J. Braz. Chem. Soc.. Publicado em: 2019-03
-
5. Genome sequence of Streptomyces gilvigriseus MUSC 26T isolated from mangrove forest
Abstract Streptomycetes remain as one of the important sources for bioactive products. Isolated from the mangrove forest, Streptomyces gilvigriseus MUSC 26T was previously characterised as a novel streptomycete. The high quality draft genome of MUSC 26T contained 5,213,277 bp with G + C content of 73.0%. Through genome mining, several gene clusters associate
Braz. J. Microbiol.. Publicado em: 2018-06
-
6. Genome Mining of Endophytic Streptomyces wadayamensis Reveals High Antibiotic Production Capability
The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which reveals several antibiotic biosynthetic pathways. Using mass spectrometry, we were able to identify desferoxa
J. Braz. Chem. Soc.. Publicado em: 2016-08
-
7. An Insight Into the Intraspecific Variation of Biosynthetic Gene Clusters Between Strains of Burkholderia thailandensis spp.
The present study aimed to investigate the intraspecific variation of biosynthetic gene clusters (BGCs) in different strains of Burkholderia thailandensis in order to guide natural products (NPs) discovery process. Species from the genus Burkholderia are emerging as promising species due to their biosynthetic potential. Through genome-mining strategies, it w
J. Braz. Chem. Soc.. Publicado em: 2016-08
-
8. Explorando produtos naturais microbianos nas fronteiras da Química e da Biologia
The chemistry of natural products has been remarkably growing in the past few decades in Brazil. Aspects related to the isolation and identification of new natural products, as well as their biological activities, have been achieved in different laboratories working on this subject in the country. More recently, the introduction of new molecular biology tool
Quím. Nova. Publicado em: 2013
-
9. Mining plant genome browsers as a means for efficient connection of physical, genetic and cytogenetic mapping: an example using soybean
Physical maps are important tools to uncover general chromosome structure as well as to compare different plant lineages and species, helping to elucidate genome structure, evolution and possibilities regarding synteny and colinearity. The increasing production of sequence data has opened an opportunity to link information from mapping studies to the underly
Genetics and Molecular Biology. Publicado em: 2012
-
10. Identification and in silico characterization of soybean trihelix-GT and bHLH transcription factors involved in stress responses
Environmental stresses caused by either abiotic or biotic factors greatly affect agriculture. As for soybean [Glycine max (L.) Merril], one of the most important crop species in the world, the situation is not different. In order to deal with these stresses, plants have evolved a variety of sophisticated molecular mechanisms, to which the transcriptional reg
Genetics and Molecular Biology. Publicado em: 2012
-
11. Mapeamento do potencial biossintético em linhagens de Streptomyces / Mapping the biosynthetic potential in Streptomyces strains
Actinobacteria are important sources of new molecules with biological activities. Streptomyces are the most important genera studied. Such microorganisms carries out among a variety of biosynthetic enzimes, two main groups known as polyketide synthase (PKS) and non ribosomal peptide synthetase (NRPS), both catalyzing the biosynthesis of polyketide and non ri
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/07/2011
-
12. In silico identification of coffee genome expressed sequences potentially associated with resistance to diseases.
Sequences potentially associated with coffee resistance to diseases were identified by in silico analyses using the database of the Brazilian Coffee Genome Project (BCGP). Keywords corresponding to plant resistance mechanisms to pathogens identified in the literature were used as baits for data mining. Expressed sequence tags (ESTs) related to each of these
GENETICS AND MOLECULAR BIOLOGY. Publicado em: 2011