Genotoxicity
Mostrando 1-12 de 262 artigos, teses e dissertações.
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1. Mutagenic damage among bronchiectasis patients attending in the pulmonology sector of a hospital in southern Brazil
SUMMARY OBJECTIVE: Bronchiectasis is a chronic respiratory disease characterized by inflammation, irreversible dilation of the bronchi, and recurrent pulmonary infections, with a high morbidity and mortality rate, but is less studied from the point of view of its prevalence and associated factors not directly related to respiratory prognosis. As it is a dis
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Comparative Study of Degradation of Reactive Dyes and Decolorization and Detoxification in Aqueous Solution Applying DyP Peroxidases Isolated from Saccharomonospora viridis (SviDyP) and Thermobifida fusca (TfuDyp)
The wastewater that originates from the widespread usage of synthetic dyes in the industry have become a severe environmental problem. Several efforts have been made to develop new types of treatment which are capable of performing the degradation of the dyes from the environment. Within this scope, much attention has been drawn to enzymatic approaches, main
J. Braz. Chem. Soc.. Publicado em: 2021-06
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3. Upconversion 3D Printed Composite with Multifunctional Applications for Tissue Engineering and Photodynamic Therapy
Upconversion nanoparticles (UCNPs) are suitable materials for bioapplications due to their ability to emit visible light under near infrared (NIR) excitation, in the biological transparency range. Polycaprolactone(PCL)-based scaffolds are widely used in tissue engineering in combination with inorganic compounds to improve bioactivity and osteoconductive prop
J. Braz. Chem. Soc.. Publicado em: 2020-04
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4. Genotoxicity, anti-melanoma and antioxidant activities of Hymenaea courbaril L. seed extract
Abstract: Hymenaea courbaril has been used to treat different diseases, although its properties are yet to be scientifically validated. The objective of this study was to determine the cytotoxicity, genotoxicity, antigenotoxicity and antioxidant potentials of hydroethanolic extract from H. courbaril seeds. Therefore, for the cytotoxicity test an anti-melanom
An. Acad. Bras. Ciênc.. Publicado em: 02/12/2019
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5. Zn, Co, Cr, As, and genotoxic effects in the ichthyofauna species from polluted and non-polluted/protected estuaries of the São Paulo coast, Brazil
Abstract: The human impact on estuarine regions results in an increasing concentration of trace elements in the environment, exposing aquatic organisms. In this study, Zn, Co, Cr, and As were determined in the muscle tissue of some fish species from Santos-São Vicente (SSV), a recognized polluted region, and in the Cananeia estuary (CAN). Genotoxicity was a
An. Acad. Bras. Ciênc.. Publicado em: 28/11/2019
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6. Protective effects of bark ethanolic extract from Spondias dulcis Forst F. against DNA damage induced by benzo[a]pyrene and cyclophosphamide
Abstract This study evaluated the genotoxicity, mutagenicity, antigenotoxicity, and antimutagenicity effects on biochemical parameters of oxidative stress of the Spondias dulcis bark ethanolic extract on mice. The extract was evaluated in the doses of 500, 1000, and 1500 mg/kg bw via gavage. To evaluate the protective effects of the extract, benzo[a]pyrene (
Genet. Mol. Biol.. Publicado em: 14/11/2019
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7. CYTOTOXIC EFFECTS OF DULOXETINE ON MKN45 AND NIH3T3 CELL LINES AND GENOTOXIC EFFECTS ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES
RESUMO CONTEXTO: O câncer gástrico é a segunda principal causa de morte relacionada ao câncer globalmente. Infelizmente, a taxa de sobrevivência dos pacientes com câncer gástrico que se submeteram à quimioterapia após a cirurgia, tem sido inferior à metade. Além disso, a quimioterapia tem muitos efeitos colaterais. Evidências atuais sugerem que
Arq. Gastroenterol.. Publicado em: 07/11/2019
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8. Genotoxic and Genoprotective Potential of Black Mulberry (Morus nigra) Fruit
Abstract: Black Mulberry (Morus nigra L.) belongs to Moraceae family. The present study evaluated the possible genotoxic and/or protective activities of black mulberry fruit juice (BMFJ), in vitro, using mitomycin C (MMC) as a positive control, by chromosomal aberrations and micronucleus assays. Human lymphocytes were treated with BMFJ concentrations alone (
An. Acad. Bras. Ciênc.. Publicado em: 28/10/2019
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9. Evaluation of hydroxyurea genotoxicity in patients with sickle cell disease
RESUMO Objetivo Avaliar o efeito da indução de danos ao DNA em células monocelulares do sangue periférico de pacientes com doença falciforme, genótipos SS e SC, tratados com hidroxiureia. Métodos Os sujeitos da pesquisa foram divididos em dois grupos: um de 22 pacientes com doença falciforme genótipos SS e SC tratados com hidroxiureia, e o outro c
Einstein (São Paulo). Publicado em: 09/09/2019
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10. CYTOTOXIC EFFECTS OF ARIPIPRAZOLE ON MKN45 AND NIH3T3 CELL LINES AND GENOTOXIC EFFECTS ON HUMAN PERIPHERAL BLOOD LYMPHOCYTES
RESUMO CONTEXTO: O câncer gástrico é conhecido como o quarto câncer mais comum. Os tratamentos atuais para o câncer danificaram os tecidos sensíveis do corpo saudável e, em muitos casos, o cancro será recorrente. Portanto, a necessidade de tratamentos que são mais eficazes é desejada. Recentemente, os pesquisadores mudaram sua atenção para os a
Arq. Gastroenterol.. Publicado em: 26/08/2019
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11. Carbonyl compounds in wine: factors related to presence and toxic effects
RESUMO: O objetivo deste estudo foi revisar os fatores tecnológicos e toxicológicos relacionados à presença de compostos carbonílicos encontrados em vinhos, incluindo acetaldeído, formaldeído, acroleína, carbamato de etila (CE) e furfural. O acetaldeído e o formaldeído podem ser formados através da oxidação do etanol e do metanol, respectivament
Cienc. Rural. Publicado em: 29/07/2019
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12. To be or not to be a carcinogen; delving into the glyphosate classification controversy
The International Agency for Research on Cancer (IARC) placed the most widely used herbicide glyphosate (GLY) into the category 2A (probably carcinogenic to humans), a classification questioned by experts from academia and industry. This article critically appraised the epidemiological and experimental data that led the IARC working group (WG) to consider GL
Braz. J. Pharm. Sci.. Publicado em: 15/07/2019