Glucocorticoid Receptors
Mostrando 1-12 de 245 artigos, teses e dissertações.
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1. Effects of chronic unpredictable stress on corticotrophin releasing factor type 2 and glucococorticoid receptors in the rat brain. / Efeitos adaptativos induzidos pelo estresse crônico imprevisível nos receptores do fator liberador de corticotrofina tipo 2 e de glicocorticóides no sistema nervoso central de ratos.
O estresse é um fenômeno conservado e observado evolutivamente, que tem como objetivo assegurar a sobrevivência do indivíduo. Porém quando o organismo perde a capacidade de se autorregular, torna-se uma ameaça. Algumas psicopatologias, como ansiedade e depressão, sugerem o envolvimento dos sistemas CRF e noradrenérgico e de níveis elevados de GCs. A
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2012
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2. Distribuição do receptor de glicocorticoide na mucosa gástrica de ratos submetidos ao desmame precoce. / Distribution of glucocorticoid receptor in the gastric mucosa of rats submitted to early weaning.
O desmame precoce (DP) consiste na abrupta substituição do leite pela dieta sólida e este padrão de alimentação pode ter impacto sobre o crescimento do estômago. Esta situação é também estressante para os filhotes e eleva os níveis de corticosterona que age ligando-se ao receptor de glicocorticoide (GR). Estudamos a expressão e a distribuição
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 21/08/2012
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3. Efeitos da restrição proteica gestacional em hipocampo de ratos machos adultos : avaliação da estrutura dendrítica tridimensional, do comportamento e de componentes neuroquímicos = Effects of gestational protein restriction in hippocampus of adult male rats / Effects of gestational protein restriction in hippocampus of adult male rats : evaluation of three-dimensional dendritic structure of hippocampal neurons, behavior and neurochemical components
Studies have demonstrated that maternal nutritional restriction during pregnancy or in early postnatal life results in hippocampus cognitive impairment and structural abnormalities in the 16-wk-old offspring. In an attempt to analyze whether gestational protein restriction might induce learning and memory impairment associated with structural changes in the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/07/2012
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4. Estresse precoce e alterações do eixo hipotálamo-pituitária-adrenal (HPA) na depressão. / Early Life Stress and alterations of the Hypothalamic-Pituitary-Adrenal (HPA) axis in depression.
Introduction: Several studies suggest that stress in early stages of development can induce persistent changes in the ability of the Hypothalamic-Pituitary-Adrenal (HPA) axis to respond to stress in adulthood. The imbalance of cortisol has been identified as a biological correlate of depressive disorders. These abnormalities seem to be related to changes in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2012
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5. Neural regulation of the stress response: glucocorticoid feedback mechanisms
The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and to restore homeostasis after the immediate challenge has subsided. Release of glucoc
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-04
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6. Early life stress, HPA axis, and depression
Considerable evidence from various studies suggests a preeminent role for early adverse experiences in the development of psychopathology, especially depression. The most recent studies reviewed herein suggest that early life stressors are associated with an increased risk for mood disorders in adulthood. This review examines the emerging literature on the r
Psychology & Neuroscience. Publicado em: 2011
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7. Maternal undernutrition and the offspring kidney: from fetal to adult life
Maternal dietary protein restriction during pregnancy is associated with low fetal birth weight and leads to renal morphological and physiological changes. Different mechanisms can contribute to this phenotype: exposure to fetal glucocorticoid, alterations in the components of the renin-angiotensin system, apoptosis, and DNA methylation. A low-protein diet d
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-11
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8. Efeito da Privação e da Restrição de sono sobre a densidade de receptores de andrógeno e de glicocorticóide no músculo esquelético / Effects of paradoxical sleep deprivation and sleep restriction upon de glucocorticoid and androgen receptors in skeletal muscle
Objetivo: Investigar o efeito da privação do sono paradoxal por 96 horas e a restrição do sono por 21 dias na densidade de receptores de glicocorticóide e de andrógenos no músculo esquelético gastrocnêmio. Métodos: Ratos machos de 3 meses de idade foram distribuídos em 6 grupos experimentais (controle, privados de sono paradoxal por 96h e rebote d
Publicado em: 2010
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9. Papel da via lkaros-FGFR4 na evolução pós-cirúrgica dos pacientes com doença de Cushing / Ikaros-FGFR4 pathway: role in the postoperative outcome of Cushings disease
Introduction: The mechanisms involved in the molecular pathogenesis of corticotroph pituitary tumors are complex, heterogeneous and in most cases remain unknown. Changes in the expression of components of Ikaros (Ik) pathway, such as receptor 4 of fibroblast growth factor (FGFR4), have been detected in pituitary tumors including corticotropinomas. Imbalance
Publicado em: 2010
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10. Identificação de agonistas e antagonistas de receptores nucleares em extratos de plantas medicinais : morus nigra l., plectranthus ornatus codd., ipomoea cairica (L) sweet e pouteria torta (mart.) radlk
The use of plants for treatment and prevention of diseases is one the oldest medicinal practices. However, for several of these plants, few or none scientific evidence of their pharmacological properties are known. Natural products, including plant derivatives, have contributed to the development of new drugs. The aim of this study is evaluate four species w
Publicado em: 2006
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11. Effectiveness of dexamethasone and doxorubicin in Ehrlich tumor of as transplanted in mice BALB/c / Eficácia da dexametasona e da doxorrubicina no tumor de Ehrlich transplantado em camundongos BALB/c
Every year, thousands of new cases of cancer appear all around the world in human beings. In Brazil around 460.000 are notified every year. In the veterinary medicine an increase of the cases of neoplasics has been noted, mainly among the pets, due to elevation of the expectative of life in dogs and cats. These aspects show the necessity to study and to impl
Publicado em: 2004
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12. The expression of the ACTH receptor
Adrenal glucocorticoid secretion is regulated by adrenocorticotropic hormone (ACTH) acting through a specific cell membrane receptor (ACTH-R). The ACTH-R is a member of the G protein superfamily-coupled receptors and belongs to the subfamily of melanocortin receptors. The ACTH-R is mainly expressed in the adrenocortical cells showing a restricted tissue spec
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-10