Gluconeogenesis
Mostrando 1-12 de 255 artigos, teses e dissertações.
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1. Pros and cons of insulin administration on liver glucose metabolism in strength-trained healthy mice
Non-diabetic individuals use hormones like insulin to improve muscle strength and performance. However, as insulin also leads the liver and the adipose tissue to an anabolic state, the purpose of this study was to investigate the effects of insulin on liver metabolism in trained non-diabetic Swiss mice. The mice were divided into four groups: sedentary treat
Braz J Med Biol Res. Publicado em: 24/01/2019
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2. A possible relationship between gluconeogenesis and glycogen metabolism in rabbits during myocardial ischemia
ABSTRACT Ischemia is responsible for many metabolic abnormalities in the heart, causing changes in organ function. One of modifications occurring in the ischemic cell is changing from aerobic to anaerobic metabolism. This change causes the predominance of the use of carbohydrates as an energy substrate instead of lipids. In this case, the glycogen is essenti
An. Acad. Bras. Ciênc.. Publicado em: 31/08/2017
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3. Molecular And 3D-Structural Characterization Of Fructose-1,6-Bisphosphate Aldolase Derived From Metroxylon Sagu
ABSTRACT Fructose-1,6-bisphosphate aldolase (FBAld) is an enzyme that catalyzes the cleavage of D-fructose-1,6-phosphate (FBP) to D-glyceraldehyde-3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP), and plays vital role in glycolysis and gluconeogenesis. However, molecular characterization and functional roles of FBAld remain unknown in sago palm. Here
Braz. arch. biol. technol.. Publicado em: 22/06/2017
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4. Insulin Promotes the Expression of the Gluconeogenic Rate-Limiting Enzymes Phosphoenolpyruvate Carboxykinase (Pepck) and Glucose 6-Phosphatase (G6pase) through PI3k/Akt/mTOR Signaling Pathway in Goose Hepatocytes
ABSTRACT To identify what makes insulin have an activating or inhibiting role in gluconeogenesis in goose hepatocytes and whether insulin regulates PEPCK and G6Pase through the PI3k/Akt/mTOR pathway or not, goose primary hepatocytes were isolated and cultured in vitro. After 12h cultured in serum-free medium, hepatocytes were incubated for 24 h in the medium
Rev. Bras. Cienc. Avic.. Publicado em: 2016-09
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5. Effect and the probable mechanisms of silibinin in regulating insulin resistance in the liver of rats with non-alcoholic fatty liver
Our previous study has shown that reduced insulin resistance (IR) was one of the possible mechanisms for the therapeutic effect of silibinin on non-alcoholic fatty liver disease (NAFLD) in rats. In the present study, we investigated the pathways of silibinin in regulating hepatic glucose production and IR amelioration. Forty-five 4- to 6-week-old male Spragu
Braz J Med Biol Res. Publicado em: 15/03/2013
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6. Combretum lanceolatum flowers extract shows antidiabetic activity through activation of AMPK by quercetin
The present study evaluated the antidiabetic activity of the Combretum lanceolatum Pohl ex Eichler, Combretaceae, flowers extract (ClEtOH) in diabetic rats. Streptozotocin-diabetic rats were divided into four groups: diabetic control, diabetic treated with 500 mg/kg of metformin and diabetic treated with 250 or 500 mg/kg of ClEtOH for 21 days. The treatment
Rev. bras. farmacogn.. Publicado em: 04/12/2012
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7. Infliximab treatment prevents hyperglycemia and the intensification of hepatic gluconeogenesis in an animal model of high fat diet-induced liver glucose overproduction
The effect of infliximab on gluconeogenesis in an animal model of diet-induced liver glucose overproduction was investigated. The mice were treated with standard diet (SD group) or high fat diet (HFD group). HFD group were randomly divided and treated either with saline (100 µl/dose, ip, twice a day) or infliximab (10 µg in 100 µl saline per dose, ip, twi
Brazilian Archives of Biology and Technology. Publicado em: 2012-06
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8. Blood glucose regulation during fasting in rats under food restriction since birth
The effect of severe food restriction since birth on regulation of fasting glycemia in male Wistar rats was investigated. The control group (CG) had free supply of chow, while the restriction group (RG) received 50% of the amount ingested by the CG. The experiments were done in adult (60 days) overnight fasted rats in which glycemia, liver free glucose level
Brazilian Archives of Biology and Technology. Publicado em: 2011-02
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9. Glucose administration inhibits the hepatic activation of gluconeogenesis promoted by insulin-induced hypoglycemia
Em estudo recente empregando ratos Wistar com 6 h de privação alimentar demonstramos que ocorre ativação da neoglicogênese hepática durante a hipoglicemia induzida por insulina (HII). Neste estudo, os efeitos da administração intraperitoneal (ip) de glicose (100 mg/kg) sobre a ativação da neoglicogênese hepática durante a HII foi investigada. Ass
Brazilian Archives of Biology and Technology. Publicado em: 2009-08
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10. Toxicidade aguda e respostas metabólicas e hematológicas do bagre do canal (Ictalurus punctatus, Rafinesque, 1818) exposto a concentração sub-letal de fenol e recuperação
Phenol and its derivates are aromatic organic compounds and there are present in the mill, domestic waste and cropscience. Moreover, phenol could induce toxicity in both freshwater and seawater fish and other animals. The aim of this work was evaluating hematological features, intermediary metabolism and muscular and cerebral acetylcholinesterase enzyme acti
Publicado em: 2009
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11. Alterações metabólicas e histopatológicas induzidas pelos inseticidas fentiona e espinosina em morcegos frugívoros / Metabolic and histopathologic changes induced by insecticides fenthion and spinosyns in fruit bats
The increasing and indiscriminate use of different types of agrochemicals can directly affect the humans and animals, causing problems related to the nervous system, cancers, endocrine alterations, and hormonal changes such as inhibition of enzymes of the glycolytic and gluconeogenesis pathway, causing hyperglycemia and pathological changes. To evaluate the
Publicado em: 2009
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12. Metabolismo energético e resposta ao jejum do morcego hematófago Diphylla ecaudata
It has been demonstrated that mammals fed with protein-rich diets are more resistant to fasting. However, the hematophagous bat Desmodus rotundus exhibits high susceptibility when subjected to food deprivation, though its diet is rich in proteins. This study investigated whether the hematophagous bat Diphylla ecaudata also shows fragility in response to fast
Publicado em: 2008