Glutamate Receptor
Mostrando 1-12 de 647 artigos, teses e dissertações.
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1. Association of glutamate metabotropic receptor polymorphisms and sensorineural hearing loss in adults of different age groups
Resumo Introdução: A perda auditiva neurossensorial é um desafio comum no mundo todo, inclui uma parte da população jovem. Embora haja muitos relatos que associem o gene do receptor metabotrópico de glutamato 7 com perda auditiva neurossensorial, não há relato, até a presente data, sobre a associação de polimorfismos do receptor metabotrópico de
Braz. j. otorhinolaryngol.. Publicado em: 07/11/2019
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2. CRF1/CRF2 and MC3/MC4 Receptors Affect Glutamate- Induced Food Intake in Neonatal Meat-Type Chicken
ABSTRACT Central glutamate, melanocortin and corticotropin systems have mediatory role on several physiologic functions in the brain, but their interactions on appetite regulation are not fully elicited. So, the aim of the current study was to determine interaction of the glutamate with melanocortin and corticotropin systems on food intake in 3-h food-depriv
Braz. J. Poult. Sci.. Publicado em: 09/05/2019
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3. In silico analysis of binding interaction of conantokins with NMDA receptors for potential therapeutic use in Alzheimer’s disease
Abstract Background The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning and memory. The subunit N-methyl D-aspartate receptor subtype 2B (NR2B) is the chief excitatory neurotransmitter receptor in the
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 23/10/2017
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4. Antinociceptive effect of semi-purified petroleum ether partition of Muntingia calabura leaves
ABSTRACT Muntingia calabura L., Muntingiaceae, is a medicinal plant for various pain-related diseases. The aims of the present study were to determine the antinociceptive profile and to elucidate the possible mechanisms of antinociception of petroleum ether partition obtained from crude methanol extract of M. calabura leaves using various animal models. The
Rev. bras. farmacogn.. Publicado em: 2016-08
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5. Swim training and the genetic expression of adipokines in monosodium glutamate-treated obese rats
Objective The aim of this study was to evaluate the genetic expression of adipokines in the adipocytes of monosodium glutamate (MSG)-treated obese rats submitted to physical activity.Materials and methods Obesity was induced by neonatal MSG administration. Exercised rats (MSG and control) were subjected to swim training for 30 min for 10 weeks, whereas their
Arch. Endocrinol. Metab.. Publicado em: 2015-06
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6. Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition
The present study investigated the effect of silibinin, the principal potential anti-inflammatory flavonoid contained in silymarin, a mixture of flavonolignans extracted from Silybum marianum seeds, on palmitate-induced insulin resistance in C2C12 myotubes and its potential molecular mechanisms. Silibinin prevented the decrease of insulin-stimulated 2-NBDG (
Braz J Med Biol Res. Publicado em: 06/03/2015
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7. Cloning and sequencing of c-DNA encoding N-methyl-D-aspartate receptor subunit-1 in the hypothalamus of male sheep
The objective of the present study was to report the molecular cloning and determination of the sequences N-methyl-D-aspartate subunit-1 receptor (NMDAR-1) in the hypothalamus of sheep. The re-amplified DNA template for NMDA -1 from the hypothalamus of male sheep was cloned using pBluescript-Sk-plasmids (pBSK, 2958 bp). Purified plasmids containing the NMDA
R. Bras. Zootec.. Publicado em: 2014-04
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8. Neuroprotection of Persea major extract against oxygen and glucose deprivation in hippocampal slices involves increased glutamate uptake and modulation of A1 and A2A adenosine receptors
Ischemic stroke is characterised by a lack of oxygen and glucose in the brain, leading to excessive glutamate release and neuronal cell death. Adenosine is produced in response to ATP depletion and acts as an endogenous neuromodulator that reduces excitotoxicity. Persea major (Meins.) L.E. Kopp (Lauraceae) is a medical plant that is indigenous to South Brazi
Rev. bras. farmacogn.. Publicado em: 2013-10
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9. Evaluation of neurotransmitters involved in the anxiolytic and panicolytic effect of the aqueous fraction of Paullinia cupana (guaraná) in elevated T maze
This study investigated the effects of repeatedly administration of an aqueous fraction of Paullinia cupana Kunth, Sapindaceae (guaraná) seeds (8 mg/kg) on rats submitted to the elevated T-maze, model of generalized anxiety and panic disorders. The selective serotonin reuptake inhibitor paroxetine (3 mg/kg), was used as a positive control. To evaluate possi
Rev. bras. farmacogn.. Publicado em: 05/03/2013
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10. The pressor effect of angiotensin-(1-7) in the rat rostral ventrolateral medulla involves multiple peripheral mechanisms
OBJECTIVE: In the present study, the peripheral mechanism that mediates the pressor effect of angiotensin-(1-7) in the rostral ventrolateral medulla was investigated. METHOD: Angiotensin-(1-7) (25 pmol) was bilaterally microinjected in the rostral ventrolateral medulla near the ventral surface in urethane-anesthetized male Wistar rats that were untreated or
Clinics. Publicado em: 2013
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11. Um estudo sobre a interação dos sistemas colinérgico nicotínico e dopaminérgico na persistência de memórias aversivas
Long-term memory (LTM) storage requires activation of the ventral tegmental area (VTA)- hippocampus dopaminergic loop and synthesis of brain-derived neurotrophic factor (BDNF) late after learning (Bekinschtein et al., 2007; Rossato et al., 2009). Nicotinic acetylcholine receptors (nAChR) modulate VTA function. Therefore, we analyzed the involvement of these
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 31/08/2012
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12. AÇÃO FARMACOLÓGICA DO 3-ALQUINIL SELENOFENO EM MODELOS DE CONVULSÃO EM RATOS JOVENS / PHARMACOLOGICAL ACTION OF 3-ALKYNYL SELENOPHENE ON MODELS OF SEIZURES IN RAT PUPS
As convulsões têm conseqüências importantes em termos de mortalidade e qualidade de vida da população afetada, sendo um fator de risco para o desenvolvimento de alterações cognitivas e anormalidades comportamentais. Tendo em vista as promissoras propriedades farmacológicas das moléculas contendo selênio, no artigo 1 avaliamos a ação anticonvulsi
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/03/2012