Growth Differentiation Factor 15
Mostrando 1-12 de 68 artigos, teses e dissertações.
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1. Correlation between GDF-15 gene polymorphism and the formation of collateral circulation in acute ST-elevation myocardial infarction
Summary Objective: To explore the correlation between growth differentiation factor 15 (GDF-15) -3148C/G polymorphism and the formation of collateral circulation in acute ST-elevation myocardial infarction (STEMI) in Han population of Taiyuan area. Method: The present study included 92 STEMI patients and 56 normal controls based on coronary angiography; ST
Rev. Assoc. Med. Bras.. Publicado em: 2017-12
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2. Aspectos da regulação do metabolismo do ferro nas hemoglobinopatias / Aspects of iron metabolism regulation in hemoglobinopathies
As hemoglobinopatias são distúrbios hereditários em que uma mutação genética leva a alteração da produção normal de hemoglobina, tal como na anemia falciforme e nas talassemias ß. Na maioria dessas doenças, ocorre anemia com necessidade transfusional variável, o que pode acarretar sobrecarga corporal de ferro. Na talassemia ß intermediária, oc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/09/2011
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3. Função do fator de crescimento progranulina na diferenciação e proliferação de células de linhagem hepática, durante o desenvolvimento embrionário de ratos Fischer 344 / Function of the progranuline growth factor in the hepatic lineage cell differentiation and proliferation during the embryo development of fisher 344 rats
Doenças envolvendo órgãos endodermicamente derivados afetam milhares de pessoas no mundo. O sucesso da terapia celular para o tratamento de doenças de órgãos oriundos da mesoderme e ectoderme gera ótimas perspectivas para o uso do mesmo em tratamento de doenças de órgãos de origem endodérmica (tireóide, pulmões, fígado, vesícula biliar e pânc
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/12/2010
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4. Expressão do growth and differentiation factor 9 (GDF9) e bone morphogenetic protein 15 (BMP15) in vitro e seu efeito no processo de luteinização em células da granulosa bovinas / Expression of growth and differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) and their effect on in vitro luteinization of bovine granulosa cells
Os sistemas de cultivo de células da granulosa vêm se desenvolvendo com o intuito de assemelhar-se às condições esteroidogênicas encontradas in vivo no folículo ovariano. A remoção do ovócito resulta na luteinização espontânea das células somáticas foliculares, com alteração no padrão esteroidogênico, que também acontece quando estas cél
Publicado em: 2010
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5. The role of diet, transforming growth factor alpha and epidermal growth factor receptor in the cell proliferation and differentiation during the postnatal development of the gastric epithelium of rats. / O papel do alimento, do fator de crescimento transformante alfa e do receptor do fator de crescimento epidermal na proliferação e diferenciação celular durante o desenvolvimento pós-natal do epitélio gástrico de ratos.
Early weaning (EW) causes changes in the gastric mucosa, including the increase in cell proliferation and Transforming Growth Factor (TGFa). In the present study, we evaluated the role of this peptide and its receptor EGFR in the control of the gastric growth. 15-d-old rats were divided into two groups: suckling (control) and EW, in which the pups were separ
Publicado em: 2009
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6. Bone morphogenetic proteins: from structure to clinical use
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor ß superfamily. Family members are expressed during limb development, endochondral ossification, early fracture, and cartilage repair. The activity of BMPs was first identified in the 1960s but the proteins responsible for bone induction were un
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-10
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7. A biologia molecular no prognóstico do carcinoma da tireóide
This overview examines some selected genetic mechanisms of cancer development. Strong evidence has been accumulated suggesting that alteration in either the struture or activity of proto-oncogene contributes to the development and for the maintenance of the malignant phenotype. Many factors are known to interfere with both normal and pathological controls of
Revista do Colégio Brasileiro de Cirurgiões. Publicado em: 2003-12
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8. Efeitos do extrato hidroalcoolico de Tabebula avellanedae sobre a resposta hematopoetica em camundongos infectados com Listeria monocytogenes
In this work, we ivestigated the effects of Tabebuia avellanedae extract (TAHE) on the growth and differentiation ofbone marrow and spleen hematopoietic progenitors in Listeria monocytogenes infected mice. Serum colony stimulating activity, weight changes of spleen and resistance ofthe animaIs as they faced infection were also evaluated. For a period of 7 da
Publicado em: 2002
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9. Characterization of Growth-Differentiation Factor 15, a Transforming Growth Factor β Superfamily Member Induced following Liver Injury
We have identified a new murine transforming growth factor β superfamily member, growth-differentiation factor 15 (Gdf15), that is expressed at highest levels in adult liver. As determined by Northern analysis, the expression of Gdf15 in liver was rapidly and dramatically up-regulated following various surgical and chemical treatments that cause acute liver
American Society for Microbiology.
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10. Acute regulation of insulin-like growth factor-I gene expression by growth hormone during adipose cell differentiation.
Insulin-like growth factor I (IGF-I) is a mitogenic polypeptide that is thought to play, under the control of growth hormone, a role in fetal development as well as post-natally. The direct effect of growth hormone on the regulation of the expression of IGF-I gene was examined in adipose Ob1771 cells. Growth hormone regulates the abundance of multiple specie
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11. Nuclear Factor YY1 Inhibits Transforming Growth Factor β- and Bone Morphogenetic Protein-Induced Cell Differentiation
Smad proteins transduce transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP) signals that regulate cell growth and differentiation. We have identified YY1, a transcription factor that positively or negatively regulates transcription of many genes, as a novel Smad-interacting protein. YY1 represses the induction of immediate-early genes
American Society for Microbiology.
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12. IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression
Dendritic cell (DC) differentiation from human CD34+ hematopoietic progenitor cells (HPCs) can be triggered in vitro by a combination of cytokines consisting of stem cell factor, granulocyte-macrophage colony-stimulating factor, and tumor necrosis factor α. The immune response regulatory cytokines, IL-4 and IL-13, promote DC maturation from HPCs, induc
The National Academy of Sciences.