Haptoglobin Polymorphism
Mostrando 1-10 de 10 artigos, teses e dissertações.
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1. Haptoglobin gene subtypes in three Brazilian population groups of different ethnicities
Haptoglobin is a plasma hemoglobin-binding protein that limits iron loss during normal erythrocyte turnover and hemolysis, thereby preventing oxidative damage mediated by iron excess in the circulation. Haptoglobin polymorphism in humans, characterized by the Hp*1 and Hp*2 alleles, results in distinct phenotypes known as Hp1-1, Hp2-1 and Hp2-2, whose frequen
Genetics and Molecular Biology. Publicado em: 26/06/2009
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2. Haptoglobin genotypes in sickle cell disease / Genotipos da haptoglobina nas doenças falciformes
Oxidative stress, particularly in the endothelium, exerts a strong influence on the genesis of sickle cell disease (SCD) vasoocclusion and, consequently, on patients clinical evolution and survival. The pathophysiology of SCD is centered on the polymerization property of the desoxy-hemoglobin (Hb) S, but genetic factors can act as modulators of its clinical
Publicado em: 2009
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3. Polymorphism of human haptoglobin and its clinical importance
Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (
Genetics and Molecular Biology. Publicado em: 2008
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4. Influencia do polimorfismo da haptoglobina na retinopatia diabetica em uma amostra da população brasileira / Haptoglobin polymorphism and diabetic retinoplasthy in a Brazilian population
Haptoglobin (Hp) is an acute phase protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1, Hp2-2) show distinct efficiencies in these activities and have been associated with susceptibility and outcome in several diseases, including diabetes mellitus (DM). It has been suggested that Hp polymorphism may influen
Publicado em: 2007
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5. Influencia do polimorfismo da haptoglobina na retinopatia diabetica em uma amostra da população brasileira / Haptoglobin polymorphism and diabetic retinoplasthy in a Brazilian population
A haptoglobina (Hp) é uma proteína de fase aguda que possui propriedades antioxidantes e imunomodulatórias. Três principais genótipos/fenótipos (Hp1-1, Hp2-1, Hp2-2) demonstram eficiências distintas em suas atividades e estão associados com a suscetibilidade e evolução de várias doenças, inclusive o diabetes mellitus (DM). Alguns estudos sugerem
Publicado em: 2007
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6. Avaliação da genotoxidade do peróxido de hidrogênio em associação com o polimorfismo da haptoglobina
Organismos aeróbicos sofrem ação constante dos radicais livres gerados nesse processo. A reação de Fenton é a maior fonte de formação de OH in vivo, ++ uma vez que o Fe é o metal mais abundante do organismo e está mais capacitado a catalisar reações de oxidação em biomoléculas. É bem conhecido que o H O causa quebrasnas fitasdo DNA por meio d
Publicado em: 2007
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7. Analysis of genetic susceptibility to mercury contamination evaluated through molecular biomarkers in at-risk Amazon Amerindian populations
We investigated Individual differences in susceptibility to methylmercury (MeHg) contamination and its relationship with polymorphisms of the detoxifying enzyme glutathione S-transferase (GST). In Brazil, some Amerindian tribes from the Amazon region have an increased level of mercury in their hair. Samples of hair and blood were taken from inhabitants of tw
Genetics and Molecular Biology. Publicado em: 2005-12
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8. Poliformismo da haptoglobina, status de ferro e proteinas de fase aguda em pacientes infectados pelo virus da imunodeficiencia humana (HIV)
Haptoglobin (Hp) is a plasma protein with antioxidant and immunomodulatory properties. Three main genotypes/phenotypes (Hp1-1, Hp2-1, Hp2-2) show distinctive efficiencies in their activities and have been related to susceptibility and/or outcome in different diseases, including HIV-infection. We compared the Hp genotype distribution between 387 Brazilian HIV
Publicado em: 2005
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9. An AvaII polymorphism in the haptoglobin alpha gene (HPA).
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10. Studies of genetic linkage between adult polycystic kidney disease and three markers on chromosome 16.
Adult polycystic kidney disease (APKD) is a common genetic disorder that is inherited as an autosomal dominant trait. Recent reports show that, in some families, the APKD gene shows close genetic linkage to two chromosome 16 specific genetic markers. We have been conducting a genetic linkage study using 29 polymorphic isoenzyme and antigenic markers in 184 m