Hard Gelatin Capsules
Mostrando 1-11 de 11 artigos, teses e dissertações.
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1. Evaluation of hard gelatin capsules and hydroxypropyl methylcellulose containing ampicillin
This study aims to develop and evaluate formulations containing ampicillin in capsules of gelatin and hydroxypropyl methylcellulose (HPMC). Two formulations (A and B) were developed. The final product quality was evaluated by testing for quality control and the results were in agreement with the Brazilian Pharmacopoeia. The formulations with HPMC capsules sh
Química Nova. Publicado em: 2012
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2. Validação de metodologia analítica para matéria-prima vegetal, extrato seco e cápsulas de gelatina dura contendo extrato seco de uncaria tomentosa (Willd) dc / Validation of analytical methods for the analysis of the Uncaria tomentosa (willd) dc raw material, dried extract and gelatin hard capsules containing it
A espécie Uncaria tomentosa (Rubiaceae) é reconhecida por diversos povos sul-americanos, devido a sua importância etnofarmacológica. Na sua maioria, os estudos realizados com U. tomentosa empregam como matéria prima vegetal a casca, devido à fração rica em alcalóides. Entre os constituintes químicos relatados para a espécie destacam-se os flavonó
Publicado em: 2011
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3. Influência de adjuvantes e técnica de enchimento sobre as características farmacêuticas de cápsulas de gelatina dura contendo teofilina / Influence of excipients and filling methodology on pharmaceutical characteristics of hard gelatine capsules containing teophyllin
A produção de cápsulas de gelatina dura em pequena escala pode ser realizada, basicamente, por dois métodos: nivelamento de superfície e pesagem individual. Visando comparar esses dois métodos, bem como avaliar a influência de adjuvantes correntemente utilizados na produção de cápsulas foi realizado um experimento fatorial 23. As respostas analisad
Publicado em: 2010
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4. Study of Fluidized Bed Hot Melt Granulation using solid Dispersion of Indomethacin / Estudo da granulação por solidificação de materiais fundidos em leito fluidizado utilizando dispersão sólida de indometacina
Recently, there is a renewed interest in the fluidized bed hot melt granulation for the preparation of solid dosage forms in the pharmaceutical industry and academy. The several advantages of this technique have attracted may researchers, but the main advantage are undoubtedly the solvent free operation and the short processing times. The aim of this work wa
Publicado em: 2009
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5. Desenvolvimento e validaÃÃo de mÃtodos bionalÃticos para dosagem de antimicrobianos em plasma humano
The Brazilian policy for generic drugs (Bill n 9.787, 10th of February, 1999) is improving the access to quality medicines by the Brazilian population. However, it makes it necessary to have analytical methods for the quantification of drugs in biological matrices with better selectivity and sensitivity for both drugs and metabolites so that they can be ap
Publicado em: 2007
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6. Comparison between gamma and beta irradiation effects on hydroxypropylmethylcellulose and gelatin hard capsules
The effects of electron beam or λ-irradiation on technological performances (capsule hardness, expressed as deforming work and dissolution time) of empty 2-shell capsules made of gelatin or hydroxypropylmethylcellulose (HPMC) were studied. Capsule structural changes induced by radiation treatment were investigated by capillary viscometry and atomic force mi
Springer-Verlag.
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7. Safety and Pharmacokinetics of Amprenavir (141W94), a Human Immunodeficiency Virus (HIV) Type 1 Protease Inhibitor, following Oral Administration of Single Doses to HIV-Infected Adults
We conducted a double-blind, placebo-controlled, parallel, dose-escalation trial to evaluate the pharmacokinetics and safety of single, oral doses of amprenavir (141W94; formerly VX-478), a potent inhibitor of human immunodeficiency virus (HIV) type 1 protease, administered as hard gelatin capsules in 12 HIV-infected subjects. The doses of amprenavir evaluat
American Society for Microbiology.
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8. Modification of theophylline release with alginate gel formed in hard capsules
The aim of this work was to establish whether alginate gel formed spontaneously in hard gelatin capsules which modifies release of a model drug, theophylline. The effects of the alginate composition, the calcium addition, and the dissolution medium on drug release were also investigated. After the capsule shell dissolved in water, at neutral pH the gel layer
Springer-Verlag.
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9. A novel solid dosage form of rifampicin and isoniazid with improved functionality
The aim of the present investigation was to develop a novel dosage form of rifampicin and isoniazid to minimize degradation of rifampicin in acidic medium and to modulate the release of rifampicin in the stomach and isoniazid in the intestine. Gastroretentive tablets of rifampicin (150 mg) were prepared by the wet granulation method using hydroxypropyl methy
Springer-Verlag.
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10. In Vivo Antiretroviral Activity of Stampidine in Chronically Feline Immunodeficiency Virus-Infected Cats
Here we report the antiretroviral activity of the experimental nucleoside reverse transcriptase inhibitor (NRTI) compound stampidine in cats chronically infected with feline immunodeficiency virus (FIV). Notably, a single oral bolus dose of 50 or 100 mg of stampidine per kg resulted in a transient ≥1-log decrease in the FIV load of circulating peripheral b
American Society for Microbiology.
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11. Enhanced Saquinavir Exposure in Human Immunodeficiency Virus Type 1-Infected Patients with Diarrhea and/or Wasting Syndrome
The protease inhibitor saquinavir was administered to 100 human immunodeficiency virus type 1 (HIV-1)-infected patients as a single 600-mg oral dose (hard gelatin capsules) with a standard breakfast, including 200 ml of grapefruit juice, during an open-label trial to assess whether diarrhea and/or wasting syndrome has consequences on its pharmacokinetics. Th
American Society for Microbiology.