Hemoglobins
Mostrando 1-12 de 189 artigos, teses e dissertações.
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1. Hemoglobin S identification in blood donors: A cross section of prevalence
ABSTRACT Introduction: In Brazil, the sickle cell trait (SCT) has an average prevalence of 4% in the general population and 6-10% among Afro-descendants. Although SCT is highly prevalent, a large segment of the population ignores their status. The Therapeutic Guidelines prohibit the transfusion of SCT red blood cells into patients with hemoglobin disorders
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. Whole-genome duplication and hemoglobin differentiation traits between allopatric populations of Brazilian Odontophrynus americanus species complex (Amphibia, Anura)
Abstract Two allopatric populations of Brazilian diploid and tetraploid Odontophrynus americanus species complex, both from São Paulo state, had their blood hemoglobin biochemically analyzed. In addition, these specimens were cytogenetically characterized. Biochemical characterization of hemoglobin expression showed a distinct banding pattern between the al
Genet. Mol. Biol.. Publicado em: 27/06/2019
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3. Effect of hydroxyurea (HU) on gelatinization mechanism of type I collagen suspensions
ABSTRACT Mutant hemoglobins thermodynamic phase transitions (HbS, HbC, etc.) have been the causes of serious hemoglobinopathies that have been affecting mankind since the dawn of human race. HbS polymerization is the best known of these transitions and the original cause of sickle cell anemia. Hydroxyurea (HU, NH2CONHOH) is widely used as the main drug admin
Matéria (Rio J.). Publicado em: 06/12/2018
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4. Investigating alpha-globin structural variants: a retrospective review of 135,000 Brazilian individuals
Background: Brazil has a multiethnic population with a high diversity of hemoglobinopathies. While screenings for beta-globin mutations are far more common, alterations affecting alpha-globin genes are usually more silent and less well known. The aim of this study was to describe the results of a screening program for alpha-globin gene mutations in a repres
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-04
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5. De novo alpha 2 hemoglobin gene (HBA2) mutation in a child with hemoglobin M Iwate and symptomatic methemoglobinemia since birth
Cyanosis in an apparently healthy newborn baby may be caused by hemoglobin variants associated with the formation of methemoglobin, collectively known as M hemoglobins. They should not be confused with genetic alterations in methemoglobin reductase enzyme systems of red cells since treatment and prognosis are completely different. A newborn male child was no
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-06
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6. Intraerythrocytic organic phosphates and hemoglobins of skua - Catharacta maccormicki (Stercoraridae): at two different stages of the year in relation to Antartic migration
Catharacta maccormicki blood samples were collected in the winter (October) and in the summer (February) in order to study the intraerythrocytic organic phosphates, hemoglobin (Hb) electrophoretic patterns, oxygen blood equilibrium and stripped Hbs, as well as the effect of 2,3-biphosphoglycerate (BPG) and inositol hexaphosphate (IHP) on oxygen affinity. All
Braz. arch. biol. technol.. Publicado em: 2013-08
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7. Alpha chain hemoglobins with electrophoretic mobility similar to that of hemoglobin S in a newborn screening program
OBJECTIVE: To characterize alpha-chain variant hemoglobins with electric mobility similar to that of hemoglobin S in a newborn screening program. METHODS: βS allele and alpha-thalassemia deletions were investigated in 14 children who had undefined hemoglobin at birth and an electrophoretic profile similar to that of hemoglobin S when they were six months ol
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013
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8. Prevalence of α-thalassemia 3.7 kb deletion in the adult population of Rio Grande do Norte, Brazil
α-Thalassemia, arising from a defect in a-globin chain synthesis, is often caused by deletions involving one or both of the a-genes on the same allele. With the aim of investigating the prevalence of α-thalassemia 3.7 kb deletion in the adult population of Rio Grande do Norte, 713 unrelated individuals, between 18 and 59 years-of-age, were analyzed. Red bl
Genetics and Molecular Biology. Publicado em: 26/07/2012
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9. Inherited hemoglobin disorders in an Afro-Amazonian community: Saracura
The most common hemoglobinopathies, viz, hemoglobins S and C, and α-and β-thalassemias, were investigated through the molecular screening of 116 subjects from the community of Saracura, comprising fugitive African slaves from farms of the municipality of Santarém, in the west of Pará State, Brazilian Amazon. The observed frequency of the HBB*S gene (0.9%
Genetics and Molecular Biology. Publicado em: 05/07/2012
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10. Hemoglobina extracelular gigante de Glossoscolex paulistus: um extraordinário sistema supramolecular hemoproteico
Giant extracellular hemoglobins are considered the summit of complexity in systems that carry oxygen, constituting an extraordinary model system to the study of hemoproteins. This class includes the hemoglobin of the annelid Glossoscolex paulistus that presents high cooperativity, great oligomeric and redox stabilities and ability of oligomeric reassociation
Química Nova. Publicado em: 2011
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11. Spectroscopic studies of the surfactants intrations with monomeric d chain of the hemoglobin of Glossoscolex paulistus / Estudos espectroscópicos das interações de surfactantes com a cadeia monomérica d da hemoglobina de Glossoscolex paulistus
A hemoglobina (Hb) do anelídeo Glossoscolex paulistus é uma Hb extracelular gigante. Esta é constituída por quatro cadeias polipeptídicas a, b, c e d contendo o heme. As cadeias a, b e c formam um trímero mantido por ligações dissulfeto e a cadeia d é um monômero. Neste trabalho, as técnicas espectroscópicas de absorção ótica no UV-Vís, fluor
Publicado em: 2008
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12. Interaction of hidrophilic porphyrins and extracellular hemoglobin with biomimetic models of biological membranes / Interação de porfirinas hidrofílicas e de hemoglobina extracelular com modelos biomiméticos de membrana biológica
In the first part of this work interactions of the cationic meso tetrakis (4-N-methilpyridil) porphyrin (TMPyP) and meso-tetrakis (4-sulfonatophenyl) porphyrin (TPPS4) in the free base forms with membrane model systems (ionic micelles, mixed micelles and phospholipids vesicles) in aqueous solutions, have been investigated by optical absorption, resonance lig
Publicado em: 2008