Hemophilia B Complications
Mostrando 1-3 de 3 artigos, teses e dissertações.
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1. Significance of the computerised pedobarography to prescription of orthosis for repetitive ankle haemarthrosis reduction, on hemophilic patients. / Importância da podobarometria computadorizada na prescrição de órteses para redução das hemartroses de repetição dos tornozelos, em pacientes hemofílicos
As hemartroses, a despeito dos avanços terapêuticos ocorridos na hemofilia, continuam sendo os eventos clínicos mais freqüentes. As hemartroses de repetição, sobretudo nos tornozelos, podem estar associadas à instabilidade articular. Sabe-se que a instabilidade articular pode contribuir para aumentar a frequência dessas complicações e prescrevem-se
Publicado em: 2005
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2. Novel therapeutic approach for hemophilia using gene delivery of an engineered secreted activated Factor VII
Hemophilia is a bleeding disorder caused by mutations in the genes encoding coagulation Factor VIII (FVIII) or FIX. Current treatment is through intravenous infusion of the missing protein. The major complication of treatment is the development of neutralizing Ab’s to the clotting factor. Infusion of recombinant activated human Factor VII (rhFVIIa), drivin
American Society for Clinical Investigation.
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3. In vivo production of human factor VII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery.
Hemophilia A is caused by defects in the factor VIII gene. This results in life-threatening hemorrhages and severe arthropathies. Today, hemophiliacs are treated with human blood-derived factor VIII. In the future, it may be possible to use gene therapy to avoid long-term complications of conventional therapy and to improve the quality of life. However, init