Hif 1
Mostrando 1-12 de 230 artigos, teses e dissertações.
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1. Dexmedetomidine Leads to the Mitigation of Myocardial Ischemia/Reperfusion-Induced Acute Lung Injury in Diabetic Rats Via Modulation of Hypoxia-Inducible Factor-1α
ABSTRACT Introduction: The objective of this study is to investigate the protective mechanism of dexmedetomidine (Dex) in myocardial ischemia/reperfusion (MIR)-induced acute lung injury (ALI) of diabetic rats by inhibiting hypoxia-inducible factor-1α (HIF-1α). Methods: Initially, healthy male Sprague Dawley rats were treated with streptozocin to induce d
Brazilian Journal of Cardiovascular Surgery. Publicado em: 2022
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2. Evaluation of HIF-1α and VEGF-A expression in radiation-induced cystitis: A case-control study
ABSTRACT The standard treatment for locally advanced cervical cancer (CC) is chemoradiotherapy. Once the bladder receives part of the radiation, a typical inflammatory condition that configures radiation-induced cystitis may develop. Chronic radiation-induced cystitis is commonly characterized by the bladder new submucosal vascularization, which is typically
Int. braz j urol.. Publicado em: 2021-03
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3. Editorial Comment: Evaluation of HIF-1α and VEGF-A expression in radiation-induced cystitis: A case-control study
RESUMO O objetivo do artigo foi realizar uma análise dos efeitos do Novo Regime Automotivo e do Inovar-Auto quanto à produção nacional, exportação e importação de veículos automotores, através de avaliação comparativa destas duas políticas públicas. Para esta comparação foram utilizados dados reais da indústria automobilística, bem como inf
Int. braz j urol.. Publicado em: 2021-03
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4. Overexpression of HIF-1α and Morphological Alterations in the Tongue of Rats Exposed To Secondhand Smoke
Resumo O tabagismo é um fator de risco para sérios problemas de saúde e está associado a diversas alterações nos tecidos da cavidade oral. O objetivo deste estudo foi avaliar a porcentagem de colágeno, densidade de mastócitos e intensidade de células imunomarcadas por anti-HIF-1α na musculatura lingual de ratos expostos passivamente à fumaça prin
Braz. Dent. J.. Publicado em: 2020-06
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5. Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats
Abstract Objective: The goal of the present study was to determine the effect of systemic and topical ozone application on alveolar bone loss (ABL) by evaluating the effect of Hypoxia-inducible factor −1 alpha (HIF-1-α) and receptor activator of NF-kB ligand (RANKL)-positive cells on histopathological and immunohistochemical changes in a rat periodontiti
J. Appl. Oral Sci.. Publicado em: 28/11/2019
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6. HIF-1α Levels in patients receiving chemoradiotherapy for locally advanced non-small cell lung carcinoma
RESUMO OBJETIVO Examinar a relação entre a resposta ao tratamento e os níveis de fator 1 induzida por hipóxia (HIF-1α) em pacientes com câncer de pulmão de células não pequenas localmente avançado (NSCLC) que receberam quimiorradioterapia (CRT). MÉTODO Oitenta pacientes com NSCLC foram incluídos no estudo e foram tratados na Faculdade de Medi
Rev. Assoc. Med. Bras.. Publicado em: 07/11/2019
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7. Assessing the association between hypoxia during craniofacial development and oral clefts
Abstract Objectives To evaluate the association between hypoxia during embryo development and oral clefts in an animal model, and to evaluate the association between polymorphisms in the HIF-1A gene with oral clefts in human families. Material and Methods The study with the animal model used zebrafish embryos at 8 hours post-fertilization submitted to 30%
J. Appl. Oral Sci.. Publicado em: 21/05/2018
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8. Hypoxia-induced hyperpermeability of rat glomerular endothelial cells involves HIF-2α mediated changes in the expression of occludin and ZO-1
This study aimed to investigate the role of hypoxia-inducible factor-2α (HIF-2α) in the expression of tight junction proteins and permeability alterations in rat glomerular endothelial cells (rGENCs) under hypoxia conditions. The expression level of HIF-2α and tight junction proteins (occludin and ZO-1) in rGENCs were examined following 5% oxygen density
Braz J Med Biol Res. Publicado em: 17/05/2018
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9. Evaluation of prophylactic and therapeutic effects of sildenafil on acute radiation proctitis in rats
Abstract Purpose: To investigate the prophylactic and therapeutical effects of sildenafil in a model of acute radiation proctitis (ARP). Methods: All experimental procedures of this study was examined by histopathological, immunohistochemical and transmission electron microscopic analysis. Results: Our histopathological evaluations indicated significant
Acta Cir. Bras.. Publicado em: 2018-04
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10. Influence Of Genetic Polymorphisms In Genes Of Bone Remodeling And Angiogenesis Process In The Apical Periodontitis
Resumo A periodontite apical persistente (PAP) é uma condição que envolve uma resposta inflamatória e imunológica causada principalmente por infecções polimicrobianas de origem anaeróbia no sistema de canais radiculares, tornando o resultado e o acompanhamento do tratamento do canal radicular intimamente relacionados à resposta do hospedeiro. O repa
Braz. Dent. J.. Publicado em: 2018-03
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11. HIF-1alpha and infectious diseases: a new frontier for the development of new therapies
ABSTRACT The aim of this review is to show the significant role of HIF-1alpha in inflammatory and infectious diseases. Hypoxia is a physiological characteristic of a wide range of diseases from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydrolase enzymes, which control the protein stability of hypoxia-inducible factor alpha 1 (HIF-1a
Rev. Inst. Med. trop. S. Paulo. Publicado em: 21/12/2017
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12. Mechanism of hif-1α mediated hypoxia-induced permeability changes in bladder endothelial cells
This study aimed to investigate the mechanism of hypoxia-inducible factor-1 alpha (HIF-1α) mediated hypoxia-induced permeability changes in bladder endothelial cells. Models of in vitro hypoxic cell culture of bladder cancer, bladder cancer cells with low HIF-1α expression and HIF-1α RNA interference (RNAi) expression vector were established. Western blot
Braz J Med Biol Res. Publicado em: 18/12/2017