Homovanillic Acid
Mostrando 1-12 de 46 artigos, teses e dissertações.
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1. Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin
TsTX is an α-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for electrographic or histopathological effects. Microdialysis revealed that the toxin increased glutamate extrac
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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2. Determinação da toxidade in vitro e vivo de compostos quinazolinicos e identificação do acido homovanilico por espectrometria de ressonancia magnetica nuclear de hidrogenio (1 ANTPOT. H) / In vivo and in vitro toxicity determination of quinazolinic compounds and identification of homovanilic acid by hydrogen (1 ANTPOT. H) nuclear magnetic resonance spectrometry
Este projeto tem a finalidade de analisar as características toxicológicas de novos compostos quinazolínicos, que foram sintetizados recentemente no Instituto de Química-UNICAMP. Uma série de derivados de 4-fenilamino quinazolinas foi sintetizada como potentes inibidores da proteína quinase e sua citotoxicidade foi demonstrada através de técnicas de
Publicado em: 2009
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3. Effects of chronic ethanol treatment on monoamine levels in rat hippocampus and striatum
We studied the effects of ethanol on concentrations of noradrenaline (NE), dopamine (DA) and serotonin (5-HT) and their metabolites in rat hippocampus and striatum. Ethanol (2 or 4 g/kg, po, from a 20% aqueous solution) was administered daily to male Wistar rats (4-13 per group) for 30 days and animals were sacrificed 30 min or 48 h after the last administra
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-12
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4. Failure of cerebrospinal fluid homovanillic acid to predict levodopa response in Parkinson's disease
Lumbar cerebrospinal fluid homovanillic acid levels were estimated in 60 patients with Parkinsonism before and during levodopa treatment. There was a slight negative correlation between pretreatment CSF homovanillic acid levels and disability. There was no correlation between pretreatment homovanillic acid levels and clinical response to levodopa. Patients w
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5. Effect of folic acid by mouth on cerebrospinal fluid homovanillic acid and 5-hydroxyindoleacetic acid concentration
Administration of 30 mg folic acid by mouth caused a significant fall in cerebrospinal fluid homovanillic acid concentration in 11 subjects. There was no significant change of 5-hydroxyindoleacetic acid concentration. The fall was less marked in five patients on anticonvulsant medication and failed to reach statistical significance. Neither homovanillic acid
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6. Low lumbar CSF levels of homovanillic acid and 5-hydroxyindoleacetic acid in multiple system atrophy with autonomic failure.
Low lumbar CSF concentrations of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) in patients with multiple system atrophy attended by autonomic failure (MSA) reflect decreased activity in central dopaminergic and serotonergic pathways. These neurochemical changes are consistent with the neuropathological involvement in MSA and distinguish suc
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7. Concentration of homovanillic acid and 5-hydroxyindoleacetic acid in the ventricular cerebrospinal fluid of patients with obstructive hydrocephalus.
In 12 patients with different posterior fossa tumours the concentrations of homovanillic acid (HVA) and of 5-hydroxyindoleacetic acid (5-HIAA) were measured in cerebrospinal fluid from the lateral ventricles. All patients had obstructive hydrocephalus. Patients with a clear increase of 5-HIAA/HVA ratio in the ventricular CSF have died subsequently. This feat
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8. Cerebrospinal fluid adenosine 3',5'-monophosphate, 5-hydroxyindoleacetic acid and homovanillic acid in patients with sleep apnoea syndrome
Adenosine 3',5'-monophosphate (cyclic AMP), 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) were determined in the cerebrospinal fluid of patients with respiratory disorder and hypersomnia and in control patients. Patients with the sleep apnoea syndrome confirmed polygraphically showed elevated levels of cyclic AMP and 5-HIAA. Cyclic AMP leve
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9. Tyrosine administration increases striatal dopamine release in rats with partial nigrostriatal lesions.
Partial, unilateral nigrostriatal lesions of varying severity were produced in rats by injecting graded doses of 6-hydroxydopamine into the substantia nigra. Formation of the dopamine metabolites dihydroxyphenylacetic acid and homovanillic acid in each surviving nigrostriatal neuron (estimated by the ratios of dihydroxyphenylacetic acid to dopamine and homov
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10. Low lumbar CSF concentrations of homovanillic acid in the autosomal dominant ataxias.
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11. The cerebrospinal fluid homovanillic acid concentration in patients with Parkinsonism treated with L-dopa.
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12. Phenolic acid concentrations in the lumbar cerebrospinal fluid of Parkinsonian patients treated with l-dopa
The acid metabolites of dopamine and 5-hydroxytryptamine were estimated in the lumbar cerebrospinal fluid (CSF) of Parkinsonian patients both before and during treatment with l-dopa, the amino acid precursor of dopamine. An attempt was made to relate clinical improvement to the biochemical results. The dopamine metabolites, 3,4-dihydroxyphenylacetic acid and