Hyperactivation
Mostrando 1-12 de 81 artigos, teses e dissertações.
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1. Hemophagocytic lymphohistiocytosis: presentation and outcome of twenty-one patients at a single institution
ABSTRACT Introduction: Hemophagocytic lymphohistiocytosis comprises a systemic hyperactivation of macrophages that requires prompt recognition of symptoms and early treatment. Objective and Method: In this context, we described clinical and laboratory characteristics, therapeutic modality and outcome of 21 patients with HLH treated at a pediatric oncology
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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2. Mechanisms by Which Metabolic Reprogramming in GSD1 Liver Generates a Favorable Tumorigenic Environment
Abstract Glycogen storage disease type 1 (GSD1) is an inherited disorder caused by impaired glucose 6-phosphatase activity. This impairment translates into the inhibition of endogenous glucose production and the subsequent accumulation of cellular glucose 6-phosphate. Excess glucose 6-phosphate enhances glycolysis, increases the production of fatty acids, ur
J. inborn errors metab. screen.. Publicado em: 30/05/2019
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3. Estresse precoce e alterações do eixo hipotálamo-pituitária-adrenal (HPA) na depressão. / Early Life Stress and alterations of the Hypothalamic-Pituitary-Adrenal (HPA) axis in depression.
Introduction: Several studies suggest that stress in early stages of development can induce persistent changes in the ability of the Hypothalamic-Pituitary-Adrenal (HPA) axis to respond to stress in adulthood. The imbalance of cortisol has been identified as a biological correlate of depressive disorders. These abnormalities seem to be related to changes in
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2012
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4. Participação das vias de estresse oxidativo na neuroproteção mediada pelo treinamento físico em fatias cerebrais submetidas à privação de oxigênio e glicose
Ischemia leads to a variety of pathological events, including excitotoxicity, inflammation, delayed neuronal dysfunction and cell death through hyperactivation of glutamate receptors and production of free radicals, such as nitric oxide (NO). The mechanism by which cerebral excess formation of NO, which mediates neuronal death involving energy depletion, lip
Publicado em: 2011
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5. Capacitation-like changes in bovine semen after cryopreservation using extenders within egg yolk or soy lecithin / Alterações semelhantes à capacitação no sêmen bovino após a criopreservação utilizando diluidores a base de gema de ovo ou lecitina de soja
O objetivo deste estudo foi avaliar os efeitos de três diluidores diferentes na criopreservação do sêmen bovino sobre a motilidade, hiperativação espermática, reação acrossomal, capacitação e peroxidação lipídica das membranas espermáticas. Foram realizadas seis colheitas de sêmen em intervalos quinzenais de dez touros zebuínos da raça Nelo
Publicado em: 2009
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6. Avaliação subjetiva e computadorizada do efeito das concentrações de íons cálcio no sêmen suíno resfriado. / Subjective evaluation and computed the effect of calcium ion concentrations in swine semen cooled.
Estudos mostram que o íon cálcio é muito importante para regulação da motilidade espermática. Desta forma, este trabalho foi dividido em dois experimentos, tendo como objetivos: 1) Avaliar o efeito de diferentes tipos e concentrações dos íons cálcio no diluidor BTS para sêmen suíno sobre a qualidade dos espermatózoides suínos mantidos resfriado
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/08/2008
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7. NEURAL AND COGNITIVE STUDIES OF THOUGHT DISORDER IN SCHIZOPHRENIA
Thought Disorder (TD) is one of the most striking features of schizophrenia and is manifested clinically as abnormal speech. Despite being a core feature of the illness very little is known of its pathophysiology. One model based on a series of word-pair priming studies formulates TD as a consequence of hyper activation of the semantic network. However, as w
Publicado em: 2002
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8. Intracellular calcium increases with hyperactivation in intact, moving hamster sperm and oscillates with the flagellar beat cycle.
At some time before fertilization, mammalian sperm undergo a change in movement pattern, termed hyperactivation. There is evidence that hyperactivation offers an advantage to sperm for detaching from the oviductal mucosa, for penetrating viscoelastic substances in the oviduct, and for penetrating the zona pellucida. Hyperactivation is known to require extrac
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9. Pivotal role of cyclic nucleoside phosphodiesterase 4 in Tat-mediated CD4+ T cell hyperactivation and HIV type 1 replication
We show here that HIV type 1 (HIV-1) Tat protein, in combination with anti-CD3/CD28 mAbs, promotes IL-2 production and proliferation of primary CD4+ T lymphocytes, obtained from HIV-1-seronegative donors. This effect was observed when Tat was immobilized on a solid support, but it was not observed with soluble Tat. Such hyperactivation was accomplished
The National Academy of Sciences.
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10. Cerebral cortical hyperactivation in response to mental stress in patients with coronary artery disease
The central nervous system (CNS) effects of mental stress in patients with coronary artery disease (CAD) are unexplored. The present study used positron emission tomography (PET) to measure brain correlates of mental stress induced by an arithmetic serial subtraction task in CAD and healthy subjects. Mental stress resulted in hyperactivation in CAD patients
The National Academy of Sciences.
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11. Histone H3 N-terminal mutations allow hyperactivation of the yeast GAL1 gene in vivo.
Recent work has shown that the yeast histone H4 N-terminus, while not essential for viability, is required for repression of the silent mating loci and activation of GAL1 and PHO5 promoters. Because histone H3 shares many structural features with histone H4 and is intimately associated with H4 in the assembled nucleosome, we asked whether H3 has similar func
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12. Hyperactivated sperm motility driven by CatSper2 is required for fertilization
Elevations of sperm Ca2+ seem to be responsible for an asymmetric form of motility called hyperactivation, which is first seen near the time of fertilization. The mechanism by which intracellular Ca2+ concentrations increase remains unknown despite considerable investigation. Although several prototypical voltage-gated calcium channels are present in spermat
National Academy of Sciences.