Imidazoline Binding Sites I2
Mostrando 1-4 de 4 artigos, teses e dissertações.
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1. EFEITO DE 2-ARIL(HETEROARIL)-4,5-DIIDRO-1H-IMIDAZÓIS SOBRE A ATIVIDADE DA ENZIMA MONOAMINA OXIDASE IN VITRO / EFFECT OF 2-ARYL-HETEROARYL-4,5-DIHYDRO-1H-IMIDAZOLES ON MONOAMINE OXIDASE ACTIVITY IN VITRO.
A monoamina oxidase (MAO) é uma enzima que contém o dinucleotídeo adenina-flavina (FAD) e que está presente na membrana externa da mitocôndria de células neuronais, glia e outras células. Seu papel inclui a regulação dos níveis de aminas biogênicas e xenobióticas no cérebro e em tecidos periféricos pela desaminação oxidativa. Com base na espe
Publicado em: 2008
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2. Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats
We investigated the acute effects of centrally acting antihypertensive drugs on the microcirculation of pentobarbital-anesthetized spontaneously hypertensive rats (SHR). The effects of the sympatho-inhibitory agents clonidine and rilmenidine, known to activate both alpha2-adrenoceptors and nonadrenergic I1-imidazoline binding sites (I1BS) in the central nerv
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-10
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3. Effects of central imidazolinergic and alpha2-adrenergic activation on water intake
Non-adrenergic ligands that bind to imidazoline receptors (I-R), a selective ligand that binds to alpha2-adrenoceptors (alpha2-AR) and mixed ligands that bind to both receptors were tested for their action on water intake behavior of 24-h water-deprived rats. All drugs were injected into the third cerebral ventricle. Except for agmatine (80 nmol), mixed liga
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-09
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4. Heterozygous α2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
Genetic manipulation of the α2A-adrenergic receptor (α2A-AR) in mice has revealed the role of this subtype in numerous responses, including agonist-induced hypotension and sedation. Unexpectedly, α2-agonist treatment of mice heterozygous for the α2A-AR (α2A-AR+/−) lowers blood pressure without sedation, indicating that more than 50% of α2A-AR must be
National Academy of Sciences.