Improves Virulence
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Avaliação de um modelo animal para estudo da infecção pelo vírus da dengue / Evaluation of an animal model for study of dengue virus infection
Dengue is the arbovirus (arthropod-borne viral disease) more widespread in tropical and subtropical countries. According to World Health Organization estimates that more than 100 million cases occur annually worldwide. Based on serologic tests of dengue viruses are classified into four antigenically distinct serotypes (DENV-1, DENV-2, DENV-3 and DENV-4). The
Publicado em: 2010
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2. Constitutive expression of the virulence genes improves the efficiency of plant transformation by Agrobacterium.
Inducible virulence (vir) genes of the Agrobacterium tumefaciens tumor-inducing (Ti) plasmid are under control of a two-component regulatory system. In response to environmental factors (phenolic compounds, sugars, pH) VirA protein phosphorylates VirG, which in turn interacts with the promoters of other vir genes, causing induction. A mutation of virG, virGN
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3. Constraint-based network model of pathogen–immune system interactions
Pathogenic bacteria such as Bordetella bronchiseptica modulate host immune responses to enable their establishment and persistence; however, the immune response is generally successful in clearing these bacteria. Here, we model the dynamic outcome of the interplay between host immune components and B. bronchiseptica virulence factors. The model extends our p
The Royal Society.
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4. relA-Independent Amino Acid Starvation Response Network of Streptococcus pyogenes
Streptococcus pyogenes (group A streptococcus [GAS]), a multiple-amino-acid-auxotrophic human pathogen, may face starvation for essential amino acids during various stages of the infection process. Since the response of GAS to such conditions is likely to influence pathogenetic processes, we set out to identify by transcriptional analyses genes and operons t
American Society for Microbiology.
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5. Disruption of Virion Host Shutoff Activity Improves the Immunogenicity and Protective Capacity of a Replication-Incompetent Herpes Simplex Virus Type 1 Vaccine Strain
The virion host shutoff (vhs) protein encoded by herpes simplex virus type 1 (HSV-1) destabilizes both viral and host mRNAs. An HSV-1 strain with a mutation in vhs is attenuated in virulence and induces immune responses in mice that are protective against corneal infection with virulent HSV-1, but it has the capacity to establish latency. Similarly, a replic
American Society for Microbiology.