Inflammatory Mediators Pharmacology
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. InteraÃÃo das vias da ciclo-oxigenase-2 e da hemeoxigenase-1 / biliverdina / monÃxido de carbono no controle da nocicepÃÃo e da inflamaÃÃo / Interaction between cyclooxygenase-2 and heme oxygenase-1 / biliverdin / carbon monoxide pathways in nociception and inflammation control in rats and mice.
Introduction: Heme oxygenase-1 (HO-1) plays a preventive role in oxidative stress. In contrast, COX-2 is involved in the pathogenesis of many inflammatory diseases and COX-2 selective inhibition has been shown to be effective in reversing inflammation without gastric side effects. However, serious cardiovascular effects of some selective COX-2 inhibitors eme
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/02/2010
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2. In vivo inhibition of nitric oxide synthases: effects on expressions of adhesion molecules and secretion of inflammatory mediators / Inibição in vivo das óxido nítrico sintases: efeitos sobre a expressão de moléculas de adesão e secreção de mediadores inflamatórios
Resultados preliminares do nosso grupo de pesquisa demonstraram que a inibição da síntese de NO por período de tempo prolongado reduz o recrutamento de leucócitos para focos inflamatórios, dependente, pelo menos em parte, da inibição da interação leucócito-endotélio e da expressão de L-selectina. 0 presente trabalho visou complementar os estudos
Publicado em: 2008
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3. Atividade antiinflamatória, antinociceptiva, e gastroprotetora do óleo essencial de croton sonderianus muell. arg. / Anti-inflammatory, antinociceptive and gastroprotective activities of essential oil from Croton sonderinus Muell. Arg.
O Croton sonderianus, conhecido como marmeleiro-preto, é popularmente empregado no tratamento de hemorragia uterina, dores de estômago, vômitos e diarréia. No presente estudo, o óleo essencial (OECS), extraído das folhas de Croton sonderianus, foi avaliado em modelos animais de inflamação aguda, nocicepção e nos testes de lesões gástricas induzid
Publicado em: 2004
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4. Mediators and receptors in the resolution of inflammation: drug targeting opportunities
The active resolution of inflammation is recognized as offering new opportunities to generate novel anti-inflammatory agents. The emerging appreciation of the importance of active resolution in regulation of inflammation also creates an imperative to examine developing and existing agents for their potential to influence these pathways. This themed issue of
Blackwell Publishing Ltd.
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5. Lipid mediator interplay: resolvin D1 attenuates inflammation evoked by glutathione-conjugated lipid peroxidation products
Non-enzymatic oxidation of cellular lipids, one of the characteristic features of inflammation, leads to formation of highly reactive and toxic α,β-unsaturated aldehydes, such as 4-hydroxy-trans-2-nonenal (HNE). Conjugation of HNE with reduced glutathione (GS-HNE) is widely believed to represent a form of detoxification. The study by Spite et al. in the cu
Blackwell Publishing Ltd.