Instability Stability Instability Cycle
Mostrando 1-12 de 38 artigos, teses e dissertações.
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1. DNA replication stress: oncogenes in the spotlight
Abstract Precise replication of genetic material is essential to maintain genome stability. DNA replication is a tightly regulated process that ensues faithful copies of DNA molecules to daughter cells during each cell cycle. Perturbation of DNA replication may compromise the transmission of genetic information, leading to DNA damage, mutations, and chromoso
Genet. Mol. Biol.. Publicado em: 13/12/2019
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2. Standardization and quality assessment for clinical grade mesenchymal stem cells from human adipose tissue
Abstract Background Mesenchymal stem cells have immense potential in stem cell-based therapies, however there is a pre-requisite to develop a curative cell dose. Adipose tissue-derived mesenchymal stem cells are promising mainly due to their potential abundance, immunomodulatory effect and remarkable differentiation potential. Nevertheless, senescence may d
Hematol., Transfus. Cell Ther.. Publicado em: 15/04/2019
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3. Choques monetários e tecnológicos e as flutuações cíclicas na economia brasileira / Monetary and technological shocks and cyclical fluctuations in the Brazilian economy
Models of real business cycles emphasize real shocks as a way to explain the behavior of the economic cycle; however, in economies like Brazil, where recent economic crises have originated in monetary instability, the nominal shocks can have great importance in explaining economic fluctuations. In this context, this study sought to examine the relevance of t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/04/2011
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4. Ecodinâmica coastal dunes of Sergipe / Ecodinâmica das dunas costeiras de Sergipe
The ecodynamics analysis of coastal dunes of Sergipe determined the role and the interactive effect of the anthropic action and of the natural dynamics in the occured fast ambient changes in two sample units of the Northern and Southern Coastline from Sergipe. The present research searched the detailing of the existing ambient dynamics in the fields of the d
Publicado em: 2008
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5. Ecodinâmica coastal dunes of Sergipe / Ecodinâmica das dunas costeiras de Sergipe
The ecodynamics analysis of coastal dunes of Sergipe determined the role and the interactive effect of the anthropic action and of the natural dynamics in the occured fast ambient changes in two sample units of the Northern and Southern Coastline from Sergipe. The present research searched the detailing of the existing ambient dynamics in the fields of the d
Publicado em: 2008
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6. The instability-stability-instability cycle in the adaptive process of motor learning / O ciclo instabilidade-estabilidade-instabilidade no processo adaptativo em aprendizagem motora
O objetivo foi investigar a aquisição de habilidades motoras, no modelo do Processo Adaptativo, testando dois ciclos de Instabilidade-Estabilidade-Instabilidade (I-E-I). Duzentos e quarenta homens adultos jovens participaram de dois experimentos realizando uma tarefa seriada de rastreamento. As variáveis dependentes foram as respostas omissas, erradas, co
Publicado em: 2007
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7. Comportamento de reator anaeróbio operado em batelada seqüencial, contendo biomassa imobilizada e submetido a aumento progressivo da concentração de substrato de fácil degradação / Behavior of the anaerobic sequencing batch reactor containing immobilized biomass and submitted to a progressive increasing of the concetration of easy degradation substrate
The main objectives of this study were to evaluate the performance of the anaerobic sequencing batch reactor when subjected to a progressive increasing of the influent glucose concentration and estimate the kinetic parameters of glucoses degradation. Initially the reactor was operated with 8-hour cycles, treating glucose at concentrations of 500, 1000 and 20
Publicado em: 2003
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8. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
We have used spectral karyotyping to assess potential roles of three different components of the nonhomologous DNA end-joining pathway in the maintenance of genomic stability in mouse embryonic fibroblasts (MEFs). MEFs homozygous for mutations that inactivate either DNA ligase IV (Lig4) or Ku70 display dramatic genomic instability, even in the absence of exo
National Academy of Sciences.
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9. Degradation of c-Fos by the 26S proteasome is accelerated by c-Jun and multiple protein kinases.
c-Fos is associated with c-Jun to increase the transcription of a number of target genes and is a nuclear proto-oncoprotein with a very short half-life. This instability of c-Fos may be important in regulation of the normal cell cycle. Here we report a mechanism for degradation of c-Fos. Coexpression of c-Fos and c-Jun in HeLa cells caused marked increase in
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10. New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability.
Phenotypes produced by gene overexpression may provide important clues to gene function. Here, we have performed a search for genes that affect chromo-some stability when overexpressed in the budding yeast Saccharomyces cerevisiae. We have obtained clones encompassing 30 different genes. Twenty-four of these genes have been previously characterized. Most of
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11. Overexpression of c-Myc Alters G1/S Arrest following Ionizing Radiation
Study of the mechanism(s) of genomic instability induced by the c-myc proto-oncogene has the potential to shed new light on its well-known oncogenic activity. However, an underlying mechanism(s) for this phenotype is largely unknown. In the present study, we investigated the effects of c-Myc overexpression on the DNA damage-induced G1/S checkpoint, in order
American Society for Microbiology.
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12. Replication and segregational stability of Bacillus plasmid pBAA1.
A cryptic plasmid, pBAA1, was identified in an industrial Bacillus strain. The plasmid is 6.8 kilobases in size and is present in cells at a copy number of approximately 5 per chromosome equivalent. The plasmid has been maintained under industrial fermentation conditions without apparent selective pressure and so is assumed to be partition proficient. The mi