Iron Overload
Mostrando 1-12 de 142 artigos, teses e dissertações.
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1. Como investigar um resultado de ferritina elevado?
Os casos de hiperferritinemia devem ser inicialmente investigados repetindo-se a dosagem de ferritina, além da dosagem de saturação de transferrina e hemograma com plaquetas. Deve-se investigar se o paciente tem história familiar de sobrecarga de ferro ou cirrose, história de reposição de ferro em excesso ou sobrecarga secundária a transfusões, u
Núcleo de Telessaúde Rio Grande do Sul. Publicado em: 12/06/2023
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2. Quais as causas de aumento da ferritina sérica?
A ferritina sérica elevada é encontrada em um grande espectro de condições, tanto genéticas como adquiridas 3. Pode estar elevada em condições como hepatopatias, alcoolismo, malignidades, doenças infecciosas e inflamatórias (ex artrite reumatoide), hipertireoidismo, infarto agudo do miocárdio, doença renal avançada e sobrecarga de ferro (hemos
Núcleo de Telessaúde Espírito Santo. Publicado em: 12/06/2023
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3. HFE hemochromatosis: an overview about therapeutic recommendations
Abstract Hemochromatosis is currently characterized by the iron overload caused by hepcidin deficiency. Large advances in the knowledge on the hemochromatosis pathophysiology have occurred due to a better understanding of the protein of the iron metabolism, the genetic basis of hemochromatosis and of other iron overload diseases or conditions which can lead
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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4. Association of FOXO3 polymorphism (rs3800231) and clinical subphenotypes of beta thalassemic individuals
Abstract Introduction Studies have shown that the loss of the FOXO3 transcriptional function is involved in the pathophysiology of some chronic erythroid disorders, including beta-thalassemia (β-thal). Therefore, the single nucleotide polymorphism (SNP) rs3800231 (35-2764A > G) could contribute to alterations in its transcriptional activity, acting as a mo
Hematology, Transfusion and Cell Therapy. Publicado em: 2022
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5. Treatment of iron overload syndrome: a general review
RESUMO INTRODUÇÃO A síndrome de sobrecarga de ferro engloba um grande espectro de etiologias que levam a um aumento da quantidade de ferro nos tecidos. Esse ferro excede a capacidade de proteção dos tecidos, levando a dano oxidativo e lesão tissular. Tratamento pode prevenir esse dano, levando à melhor sobrevida. METODOLOGIA A literatura dos últi
Rev. Assoc. Med. Bras.. Publicado em: 10/10/2019
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6. Hepcidin is a useful biomarker to evaluate hyperferritinemia associated with metabolic syndrome
Abstract: Investigation of hyperferritinemia in metabolic syndrome patients represents a diagnostic challenge, but it is essential for the identification of individuals with iron overload. Hepcidin negatively regulates iron absorption and release. An increase in hepcidin occurs when iron levels are sufficient or in inflammatory states, conditions often assoc
An. Acad. Bras. Ciênc.. Publicado em: 13/05/2019
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7. Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-
Braz J Med Biol Res. Publicado em: 19/10/2017
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8. Deferasirox-induced urticarial vasculitis in a patient with myelodysplastic syndrome
Abstract Deferasirox is an iron chelator agent used in the treatment of diseases with iron overload, such as thalassemia and myelodysplastic syndrome. Although the majority of adverse reactions of deferasirox involve gastrointestinal symptoms and increase in serum creatinine and transaminases, skin rashes, such as maculopapular and urticarial eruptions, have
An. Bras. Dermatol.. Publicado em: 2017
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9. Effect of the consumption on buriti oil on the metabolism of rats induced by iron overload
Objectives To compare the effect of the consumption of buriti oil and soybean oil on the metabolism of rats under stress induced by iron overload.Materials and methods A total of 28 rats were randomized into control groups who consumed diet added of soybean (CS) or buriti oil (CB) and gavage with saline and two experimental groups who consumed diet added of
Arch. Endocrinol. Metab.. Publicado em: 25/09/2015
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10. The role of magnetic resonance imaging in the evaluation of transfusional iron overload in myelodysplastic syndromes
Myelodysplastic syndromes represent a group of heterogeneous hematopoietic neoplasms derived from an abnormal multipotent progenitor cell, characterized by a hyperproliferative bone marrow, dysplasia of the cellular hemopoietic elements and ineffective erythropoiesis. Anemia is a common finding in myelodysplastic syndrome patients, and blood transfusions are
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-08
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11. HFE MUTATIONS AND IRON OVERLOAD IN PATIENTS WITH ALCOHOLIC LIVER DISEASE
ContextoA doença hepática alcoólica (DHA) está geralmente associada à sobrecarga de ferro, que pode contribuir para a sua patogênese, através do aumento do estresse oxidativo e dano celular. As descrições existentes na literatura sobre a associação entre mutações HFE e a gravidade da DHA nem sempre são concordantes.ObjetivosComparar a prevalên
Arq. Gastroenterol.. Publicado em: 2013-03
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12. Impact of iron overload on interleukin-10 levels, biochemical parameters and oxidative stress in patients with sickle cell anemia
OBJECTIVE: The aim of this study was to evaluate the impact of iron overload on the profile of interleukin-10 levels, biochemical parameters and oxidative stress in sickle cell anemia patients. METHODS: A cross-sectional study was performed of 30 patients with molecular diagnosis of sickle cell anemia. Patients were stratified into two groups, according to t
Rev. Bras. Hematol. Hemoter.. Publicado em: 2013