Junctional Proteins
Mostrando 1-12 de 88 artigos, teses e dissertações.
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1. Inherited epidermolysis bullosa: update on the clinical and genetic aspects,
Abstract Inherited epidermolysis bullosa is a group of genetic diseases characterized by skin fragility and blistering on the skin and mucous membranes in response to minimal trauma. Epidermolysis bullosa is clinically and genetically very heterogeneous, being classified into four main types according to the layer of skin in which blistering occurs: epidermo
An. Bras. Dermatol.. Publicado em: 2020-10
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2. Reproductive alternatives for patients with dystrophic epidermolysis bullosa
RESUMO O termo “epidermólise bolhosa” descreve um grupo de afecções cutâneas causadas por mutações em genes que codificam proteínas relacionadas à aderência dermoepidérmica. Nos Estados Unidos, estima-se a ocorrência de 50 casos de epidermólise bolhosa por 1 milhão de nascidos vivos, sendo 92% deles da forma simples, 5% da forma distrófica,
Einstein (São Paulo). Publicado em: 13/06/2019
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3. Estudo da expressão das proteínas juncionais e dos fatores inflamatórios em pacientes com doença do refluxo gastroesofágico erosiva e não erosiva / Study of expressions of junctionals proteins and inflammatory factors in patients with gastro-oesophageal reflux disease and non-erosive reflux disease
Pacientes com doença do refluxo não erosiva apresentam sintomas típicos causados pelo refluxo do conteúdo gástrico para o esôfago. Entretanto, estes pacientes não apresentam alterações de mucosa visualizadas à endoscopia. O objetivo deste estudo é caracterizar a expressão de moléculas relacionadas à junção celular (claudinas 1, 3 e 4), da pro
Publicado em: 2009
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4. Expression of gap junction proteins, the connexins, in normal and neoplastic osseous tissues from dogs / Estudo da expressão das proteínas de junções intercelulares do tipo Gap, as conexinas, em tecido ósseo normal e neoplásico de cães
Increasing evidence indicates that junctional communiction by gap juctions has a critical role in a bone physiology. The main connexin (Cx) express involved in development, differentiation and regulation of tissue growth, is the called Cx43. However, other, two connexis are expressed: Cx45 and Cx46. Cx46 is retained as monomers in a trans-golgi compartment o
Publicado em: 2008
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5. Caracterização da DNase da peçonha da serpente Bothrops alternatus : comparação com a DNase acida de mamiferos envolvida em apoptose / Characterization of a Dnase from Bothrops alternatus snake venom : comparision with mamalian acid Dnases involved in apoptosis
Bothrops snake venoms are cytotoxic to a variety of cells (endothelial, smooth muscle, renal and inflammatory cells), and may cause cell death by apoptosis. The venom components implicated in apoptosis include metalloproteinases and L-amino acid oxidase. In contrast, although acidic deoxyribonucleases (DNase II) have been implicated in DNA fragmentation duri
Publicado em: 2008
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6. Endocytosis of Epithelial Apical Junctional Proteins by a Clathrin-mediated Pathway into a Unique Storage Compartment
The adherens junction (AJ) and tight junction (TJ) are key regulators of epithelial polarity and barrier function. Loss of epithelial phenotype is accompanied by endocytosis of AJs and TJs via unknown mechanisms. Using a model of calcium depletion, we defined the pathway of internalization of AJ and TJ proteins (E-cadherin, p120 and β-catenins, occludin, JA
The American Society for Cell Biology.
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7. Fractionation of the Epithelial Apical Junctional Complex: Reassessment of Protein Distributions in Different SubstructuresD⃞V⃞
The epithelial apical junctional complex (AJC) is an important regulator of cell structure and function. The AJC is compartmentalized into substructures comprising the tight and adherens junctions, and other membrane complexes containing the membrane proteins nectin, junctional adhesion molecule, and crumbs. In addition, many peripheral membrane proteins loc
The American Society for Cell Biology.
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8. Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and α-actinin are components of the nephrin multiprotein complex
Nephrin is a cell surface receptor of the Ig superfamily that localizes to slit diaphragms, the specialized junctions between the interdigitating foot processes of the glomerular epithelium (podocytes) in the kidney. Mutations in the NPHS1 gene encoding nephrin lead to proteinuria and congenital nephrotic syndrome, indicating that nephrin is essential for no
National Academy of Sciences.
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9. Xenopus connexin38 forms hemi-gap-junctional channels in the nonjunctional plasma membrane of Xenopus oocytes.
A nonselective cation current activated by depolarization (Ic) is present in the nonjunctional membrane of Xenopus oocytes. This current shares a number of properties with hemi-gap-junctional currents induced by exogenous gap-junctional proteins in oocytes and with a nonjunctional current seen in teleost retinal horizontal cells including nonselective permea
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10. Switch in gap junction protein expression is associated with selective changes in junctional permeability during keratinocyte differentiation.
Gap junctional communication provides a mechanism for regulating multicellular activities by allowing the exchange of small diffusible molecules between neighboring cells. The diversity of gap junction proteins may exist to form channels that have different permeability properties. We report here that induction of terminal differentiation in mouse primary ke
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11. Purified lens junctional protein forms channels in planar lipid films.
Junctions isolated from bovine lenses were solubilized with the detergent octyl glucoside, and their protein(s) was reconstituted in unilamellar vesicles. The protein(s) appears as annular-shaped intramembrane particles approximately equal to 10 nm in diameter on the vesicles' fracture faces. The addition of the vesicle-containing junctional protein(s) to bo
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12. Phosphorylation of connexin43 gap junction protein in uninfected and Rous sarcoma virus-transformed mammalian fibroblasts.
Gap junctions are membrane channels that permit the interchange of ions and other low-molecular-weight molecules between adjacent cells. Rous sarcoma virus (RSV)-induced transformation is marked by an early and profound disruption of gap-junctional communication, suggesting that these membrane structures may serve as sites of pp60v-src action. We have begun