Kallikreins
Mostrando 1-12 de 20 artigos, teses e dissertações.
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1. Estudo de modelagem molecular e de inibição enzimática das calicreínas teciduais humanas 5 e 7 por compostos isocumarínicos e derivados de isomanídeos
A família das calicreínas teciduais humanas é composta de quinze serino proteases, sendo o gene denotado por KLK e a proteína por KLK seguida do número correspondente. Elas apresentam atividade semelhante à tripsina, com exceção das KLK3, 7 e 9 que apresentam atividade semelhante à quimotripsina. São transcritas como pré-pró-enzimas, sendo que ap
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/08/2011
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2. Action of recombinant Bauhinia inhibitors on prostate cancer cell line. / Ação de inibidores recombinantes de Bauhinia sobre a linhagem celular de câncer de próstata.
Prostate cancer occurs in Brazil with high rates of incidence and mortality. Invasion from the primary tumor and metastasis result in poorer prognosis. Diverse classes of protein play a role for the progression of metastasis. Tissue kallikreins, e.g., hK3 (PSA) and integrins are directly related to this neoplasia, as well as, in cell adhesion, differentiatio
Publicado em: 2009
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3. Caracterização farmacologica do relaxamento da musculatura lisa do corpo cavernoso humano isolado induzido por cininas
Objective: To caracterize the kinin receptor subtype involved in the relaxation of human isolated corpus cavernosum (HCC) induced by bradykinin (BK). Lysbradykinin (Lys-BK), Met-Lys-bradykinin (Met-Lys-BK) and des-Arg9-bradykinin (des-Arg9-BK), and to investigate whether the kinin-induced relaxation of HCC results from the stimulation of nonadrenergic, nonch
Publicado em: 2002
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4. Studies on the prekallikrein (kallikreinogen)-kallikrein enzyme system of human plasma: I. Isolation and purification of plasma kallikreins
By measurement of its arginine esterase activity, plasma kallikrein was purified from fresh frozen ACD plasma. The steps involved alcohol fractionation, isoelectric precipitation, and carboxymethyl (CM) Sephadex and DEAE cellulose chromatography. Three enzymatically active fractions were finally isolated and termed plasma kallikreins I, II, and III; they rep
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5. Anionic salivary proteins associated with connective tissue disorders: sialated tissue kallikreins.
Parotid saliva was collected from 32 patients with rheumatoid arthritis, 10 with systemic lupus erythematosus, three with mixed connective tissue disease, 12 with progressive systemic sclerosis, two with primary Sjögren's syndrome, and four with Raynaud's syndrome. Tissue kallikreins were measured by radioimmunoassay, and saliva samples were subjected to is
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6. Studies on the prekallikrein (kallikreinagen)-kallikrein enzyme system of human plasma. I. Isolation and porification of plasma kallikreins
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7. Studies on the prekallikrein (kallikreinogen)—kallikrein enzyme system of human plasma: II. Evidence relating the kaolin-activated arginine esterase to plasma kallikrein
Evidence is presented in this paper that the kaolin-activated arginine esterase of plasma is related to plasma kallikrein activity. Such a relationship is based on studies that (1) establish a constant ratio of esterase activity on various synthetic substrates for the kaolin-activated arginine esterase, purified kallikrein(s), and preparations obtained durin
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8. Rat pancreatic kallikrein mRNA: nucleotide sequence and amino acid sequence of the encoded preproenzyme.
We have cloned via recombinant DNA technology the mRNA sequence for rat pancreatic preprokallikrein. Four cloned overlapping double-stranded cDNAs gave a continuous mRNA sequence of 867 nucleotides beginning within the 5'-noncoding region and extending to the poly(A) tail. The mRNA sequence reveals that pancreatic kallikrein is synthesized as a prezymogen of
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9. Kinetic analysis of the interaction of human tissue kallikrein with single-chain human high and low molecular weight kininogens.
Human low molecular weight kininogen (LMWK) and high molecular weight kininogen (HMWK) have been purified to apparent homogeneity as intact, single-chain molecules. When they interacted with homologous urinary kallikrein, 0.9 mol of kinin per mol of substrate was released from LMWK and 0.7 mol of kinin per mol of substrate was released from HMWK. These funct
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10. The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland.
Mouse submaxillary gland contains many proteolytic enzymes, the most widely studied of which are the kallikreins. This gland also contains high levels of nerve growth factor (NGF), which is isolated as a complex of three subunits, alpha, beta, and gamma. We report here the cloning and sequence analysis of a novel kallikrein from mouse submaxillary gland. Ant
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11. Cellular basis for the differential response of mouse kallikrein genes to hormonal induction.
The expression of many mouse kallikrein genes in the salivary gland is sexually dimorphic and inducible in females by administration of testosterone or thyroxine. Induction is slow (3-7 days) and is accompanied by the non-uniform differentiation of the cell type expressing these genes from striated duct (SD) cells (female) to granular convoluted tubule (GCT)
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12. Flaujeac trait. Deficiency of human plasma kininogen.
Flaujeac trait plasma resembled Hageman trait or Fletcher trait, in that the intrinsic coagulation pathway, plasma fibinolytic pathway, kinin-forming system, permeability factor of dilution (PF/dil) phenomenon were abnormal. The defect in each assay was reconstituted by afactor separable from Hageman factor or Fletcher factor. This substance was an alpha-glo