Leishmania Life Cycle
Mostrando 1-12 de 40 artigos, teses e dissertações.
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1. Diversity, natural infection and blood meal sources of phlebotomine sandflies (Diptera, Psychodidae) in the western Brazilian Amazon
BACKGROUND The state of Rondônia (RO) is a hot spot for human cases of cutaneous leishmaniasis. Many sandfly species in RO are putative vectors of leishmaniasis. OBJECTIVES This study examines the diversity patterns and the presence of Leishmania DNA and blood meal sources of sandflies in RO. METHODS A sandfly survey was performed between 2016 and 201
Mem. Inst. Oswaldo Cruz. Publicado em: 29/07/2019
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2. RNA viruses in trypanosomatid parasites: a historical overview
Viruses of trypanosomatids are now being extensively studied because of their diversity and the roles they play in flagellates’ biology. Among the most prominent examples are leishmaniaviruses implicated in pathogenesis of Leishmania parasites. Here, we present a historical overview of this field, starting with early reports of virus-like particles on elec
Mem. Inst. Oswaldo Cruz. Publicado em: 19/02/2018
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3. Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids
The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TE
Mem. Inst. Oswaldo Cruz. Publicado em: 2017-08
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4. HSP70 of Leishmania amazonensis alters resistance to different stresses and mitochondrial bioenergetics
The 70 kDa heat shock protein (HSP70) is a molecular chaperone that assists the parasite Leishmania in returning to homeostasis after being subjected to different types of stress during its life cycle. In the present study, we evaluated the effects of HSP70 transfection of L. amazonensis promastigotes (pTEX-HSP70) in terms of morphology, resistance, infectiv
Mem. Inst. Oswaldo Cruz. Publicado em: 10/06/2016
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5. Functional complementation of Leishmania (Leishmania) amazonensis AP endonuclease gene (lamap) in Escherichia coli mutant strains challenged with DNA damage agents
During its life cycle Leishmania spp. face several stress conditions that can cause DNA damages. Base Excision Repair plays an important role in DNA maintenance and it is one of the most conserved mechanisms in all living organisms. DNA repair in trypanosomatids has been reported only for Old World Leishmania species. Here the AP endonuclease from Leishmania
Mem. Inst. Oswaldo Cruz. Publicado em: 2016-05
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6. Biological aspects of immature stage of Nyssomyia whitmani (Antunes and Coutinho) (Diptera, Psychodidae, Phlebotominae) in laboratory conditions
Nyssomyia whitmani (Antunes and Coutinho, 1939) has been considered as a complex of cryptic species, and some of the populations of this complex plays an important role in the transmission of Leishmania spp. in Brazil. The present study reports the biological aspects concerning the productivity out of eggs and the development time of the descendants of fema
Rev. Bras. entomol.. Publicado em: 2015-06
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7. Regulatory volume decrease in Leishmania mexicana: effect of anti-microtubule drugs
The trypanosomatid cytoskeleton is responsible for the parasite's shape and it is modulated throughout the different stages of the parasite's life cycle. When parasites are exposed to media with reduced osmolarity, they initially swell, but subsequently undergo compensatory shrinking referred to as regulatory volume decrease (RVD). We studied the effects of
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-02
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8. Estudo da capacidade vetorial de Migonemya migonei (França) e de Pintomya fischeri (Pinto) (Diptera: Psychodidae) para Leishmania (Leishmania) infantum chagasi Cunha &Chagas / Study of the vectorial capacity of Migonemyia migonei (França) and of Pintomyia fischeri (Pinto) (Diptera: Psychodidae) as regards Leishmania (Leishmania) infantum chagasi Cunha &Chagas
Introduction - Visceral leishmaniasis has been affecting canine and human populations in various urban centers in São Paulo state and the area of its distribution has been growing steadily. Since its introduction into the state, the infection has been identified in canine and feline populations of Greater São Paulo. Differently from other areas, where the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/11/2011
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9. Proteases de Leishmania: novos alvos para o desenvolvimento racional de fármacos
Leishmania causes tegumental and visceral diseases called leishmaniasis. Disease control is possible interrupting the transmission cycle, but HIV co-infection, chemotheraphy toxicity and lack of a vaccine are paramount difficulties. So, is necessary to study new Leishmania molecules and investigate the possibility to develop rational drugs using these molecu
Química Nova. Publicado em: 2010
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10. The relationship between the cellular location of Leishmania (Leishmania) amazonensis arginase and its role during murine macrophage infection / Relação entre a localização celular da enzima arginase de Leishmania (Leishmania) amazonensis e seu papel na infecção de macrófagos murinos
In the mammal host, Leishmania parasites live inside macrophages escaping from their microbicidal mechanisms, such as the nitric oxide (NO) production. The macrophage NO production by inducible nitric oxide synthase (iNOS) requires L-arginine as substrate, the same amino acid required by arginase to generate ornithine and urea. So, arginase may play a dual r
Publicado em: 2010
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11. Estudo do ciclo de vida, fonte alimentar e capacidade vetorial de Lutzomyia whitmani no Maranhão, Brasil / Study the life cycle, food source and vectorial capacity of Lutzomyia whitmani in Maranhao, Brazil
Este estudo teve como objetivo a análise da suscetibilidade experimental de Lutzomyia whitmani para infecção com Leishmania brasiliensis causadora da Leishmaniose Cutânea e Cutâneo-Mucosa e Leishmania amazonensis causadora da Leishmaniose Cutânea Difusa. Para isso, uma colônia de L. whitmani foi estabelecida com a finalidade de fornecer espécimes liv
Publicado em: 2009
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12. AVALIAÇÃO DA RESPOSTA IMUNE A VACINAS DE ANTÍGENO PARTICULADO DE Leishmania sp E SUA ASSOCIAÇÃO COM VACINA DE DNA pCI-neo-p36(LACK) EM CAMUNDONGOS BALB/c DESAFIADOS COM Leishmania chagasi
American visceral leishmaniasis is a chronic disease that can reach 98% of human mortality when not treated. Due to its severity and high incidence, vaccination has become an important approach to protection. Several vaccines have been tested, amongst then, freeze-thawed antigen and DNA vaccines. These two vaccines have demonstrated the capacity to reduce th
Publicado em: 2007