Leukocytes Recruitment
Mostrando 1-12 de 133 artigos, teses e dissertações.
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1. Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production
Tephrosia toxicaria (Sw.) Pers., which is currently known as T. sinapou (Buc'hoz) A. Chev., Fabaceae, is a source of compounds such as flavonoids, however, few studies addressed the anti-inflammatory and antioxidant effects of T. sinapou. Therefore, we evaluated the antioxidant mechanisms of the T. sinapou ethyl acetate extract in vitro, and whether the extr
Revista Brasileira de Farmacognosia. Publicado em: 09/01/2012
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2. Papel dos leucócitos na fisiopatologia da anemia falciforme / Role of leukocytes in sickle cell anemia pathophysiology
Sickle Cell Disease (SCD) is a disorder of hemoglobin synthesis, caused by a point mutation, and resulting in the production of abnormal sickle hemoglobin, HbS. The consequence of low oxygen levels is HbS polymerization, which is responsible for the vaso-occlusive phenomenon that is the hallmark of the disease. SCD is a chronic inflammatory disease character
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2011
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3. Evidence for eosinophil recruitment, leukotriene B4 production and mast cell hyperplasia following Toxocara canis infection in rats
It is well known that eosinophilia is a key pathogenetic component of toxocariasis. The objective of the present study was to determine if there is an association between peritoneal and blood eosinophil influx, mast cell hyperplasia and leukotriene B4 (LTB4) production after Toxocara canis infection. Oral inoculation of 56-day-old Wistar rats (N = 5-7 per gr
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-04
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4. Modulação de eventos da imunidade humoral e celular por venenos brutos e componentes dos venenos de Bothrops jararacussu e Bothrops pirajai / Modulation of events of humoral and cellular immunity by crude venom and components of Bothrops jararacussu and Bothrops pirajai
Snakes of the genus Bothrops are responsible for 90% of snakebites in Brazil. Their venoms cause local effects in humans and animals, such as hemorrhage, edema, pain and necrosis, characteristic of an inflammatory response. The mechanism is not well defined. These effects are related to the combined action of proteases, substances that induce bleeding and ph
Publicado em: 2010
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5. Studies on the leukocyte component and chemotactic mediators of the inflammatory reaction induced by Bothrops moojeni venom. Participation of mast cells and histamine in leukocyte recruitment. / Estudo do componente leucocitário e de mediadores quimiotáticos da reação inflamatória induzida pelo veneno de Bothrops moojeni. Participação de mastócitos e da histamina no recrutamento leucocitário
In this study the effects of Bothrops moojeni venom (BmV) on the cellular component of inflammatory responses and the mechanisms involved in this effect were investigated. The effects of venom on peritoneal and circulating leukocyte numbers and on the release of inflammatory mediators, such as LTB4, TXA2, PGD2, MIP-1 and KC, were assessed. The role of both m
Publicado em: 2009
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6. VerificaÃÃo das atividades citotÃxica e antitumoral do Cissus sicyoides em associaÃÃo com (glucana β-1,3-D-glicopiranose) ImunoglucanÂ
Cissus sicyoides L. tem origem na RepÃblica Dominicana e popularmente à utilizada em diversas doenÃas, como a epilepsia, derrame cerebral, bem como, em abscessos e no tratamento do diabetes mellitus do tipo 2 . Esta espÃcie apresenta atividades antiinflamatÃrias e anti-reumÃticas, antiepilÃptico, antihipertensivo, antitÃrmico e antidiabÃtico. O obje
Publicado em: 2009
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7. Estudo dos mecanismos de ação da hidroquinona e fenol sobre o recrutamento leucocitário em respostas inflamatórias / Study of mechanisms of action of hydroquinone and phenol on leukocyte recruitment in inflammatory response
Hydroquinone (HQ) is one of the metabolites of benzene responsible for the toxic effects of exposure to solvent, as well as being part of the diet, medicines, tobacco and polluting the environment. Considering the immunotoxicity of this substance, our laboratory has investigated the role of exposure to HQ by prolonged period of time on acute inflammatory res
Publicado em: 2008
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8. Avaliação da função neutrofílica em indivíduos infectados pelo HTLV-I. / Evaluation of the neutophil function in HTLV-I Infected individuals.
Human T-cell lymphotropic virus-type I (HTLV-I) induces activation and spontaneous proliferation of T cells with production of type-I pro-inflammatory cytokines (IFN-γ and TNF-α). However, little is known about the innate immune response in HTLV-I infection. HTLV-I infected individuals have higher spontaneous neutrophil activation than HTLV-I seron
Publicado em: 2007
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9. Importância da interação entre a integrina Mac-1 leucócitos e a glicoproteína Ib alfa das plaquetas para o recrutamento de leucócitos pelas plaquetas e para a resposta inflamatória à lesão vascular / The importance of the leukocyte integrin Mac-1 and platelet glycoprotein Ib? interaction for the leukocyte recruitment by platelets and for the inflammatory response to vascular injury
INTRODUÇÃO: A interação entre leucócitos e plaquetas é fundamental para o início e a progressão da reestenose e da aterosclerose. Recentemente foi evidenciado em estudos in vitro que a integrina Mac-1 dos leucócitos se liga à glicoproteína Ibalfa (GP Ibalfa) das plaquetas e que esta interação possui uma função central na firme adesão e transm
Publicado em: 2007
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10. Chemokines in the cerebrospinal fluid of patients with active and stable relapsing-remitting multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the human central nervous system. Although its etiology is unknown, the accumulation and activation of mononuclear cells in the central nervous system are crucial to its pathogenesis. Chemokines have been proposed to play a major role in the recruitment and activation of leukocytes in
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-04
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11. Selective suppression of leukocyte recruitment in allergic inflammation
Allergic diseases result in a considerable socioeconomic burden. The incidence of allergic diseases, notably allergic asthma, has risen to high levels for reasons that are not entirely understood. With an increasing knowledge of underlying mechanisms, there is now more potential to target the inflammatory process rather than the overt symptoms. This focuses
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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12. An overview of the effects of annexin 1 on cells involved in the inflammatory process
The concept of anti-inflammation is currently evolving with the definition of several endogenous inhibitory circuits that are important in the control of the host inflammatory response. Here we focus on one of these pathways, the annexin 1 (ANXA1) system. Originally identified as a 37 kDa glucocorticoid-inducible protein, ANXA1 has emerged over the last deca
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03