Linkage Disequilibrium
Mostrando 1-12 de 567 artigos, teses e dissertações.
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1. Influence of Neuropeptide Y and Neuropeptide Y 2 Receptor Variants in Acute Coronary Syndrome
Abstract Background The neuropeptide Y (NPY) is one of the most abundant neurotransmitters in the nervous system. NPY acts as a potent stimulator of angiogenesis, inflammation, and adipogenesis, through the NPY 2 receptor (NPY2R). Changes in the NPY signaling pathway have been linked to Acute Coronary Syndrome (ACS). Objectives The purpose of this study
International Journal of Cardiovascular Sciences. Publicado em: 2022
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2. Usefulness of a multiplex PCR for the rapid identification of Candida glabrata species complex in Mexican clinical isolates
ABSTRACT Candida glabrata complex includes three species identified through molecular biology methods: C. glabrata sensu stricto , C. nivariensis and C. bracarensis . In Mexico, the phenotypic methods are still used in the diagnosis; therefore, the presence of C. nivariensis and C. bracarensis among clinical isolates is still unknown. The aim of this study w
Rev. Inst. Med. trop. S. Paulo. Publicado em: 08/08/2019
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3. SNP markers associated with soybean partial resistance to Phytophthora sojae
Abstract Phytophthora root and stem rot is one of the most aggressive diseases in soybean crop. The use of resistant cultivars is the main strategy to reduce losses caused by the pathogen. This study aims to identify SNP markers associated with genes or QTLs that provide soybean with partial resistance to Phytophthora sojae. A total of 169 soybean cultivars
Crop Breed. Appl. Biotechnol.. Publicado em: 11/04/2019
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4. Linkage disequilibrium and past effective population size in native Tunisian cattle
Abstract To carry out effective genome-wide association studies, information about linkage disequilibrium (LD) is essential. Here, we used medium-density SNP chips to provide estimates of LD in native Tunisian cattle. The two measures of LD that were used, mean r2 and D’, decreased from 0.26 to 0.05 and from 0.73 to 0.40, respectively, when the distance be
Genet. Mol. Biol.. Publicado em: 18/02/2019
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5. Clinical evaluation of a substitute of HLA-B*58:01 in different Chinese ethnic groups
Abstract The goal of this research was to investigate the linkage disequilibrium between rs9263726 and HLA-B*58:01 in different Chinese ethnic groups (Han, Tibet, and Hui) and to study the feasibility of rs9263726 replacing HLA-B*58:01 as an efficient indicator of potential allopurinol hypersensitivity syndrome. In this study, rs9263726 and HLA-B*58:01 were
Genet. Mol. Biol.. Publicado em: 02/08/2018
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6. Linkage disequilibrium levels and allele frequency distribution in Blanco Orejinegro and Romosinuano Creole cattle using medium density SNP chip data
Abstract The linkage disequilibrium (LD) between molecular markers affects the accuracy of genome-wide association studies and genomic selection application. High-density genotyping platforms allow identifying the genotype of thousands of single nucleotide polymorphisms (SNPs) distributed throughout the animal genomes, which increases the resolution of LD ev
Genet. Mol. Biol.. Publicado em: 2018-06
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7. HSF1 and HSPA6 as functional candidate genes associated with heat tolerance in Angus cattle
ABSTRACT The purpose of this study was to access and characterize single nucleotide polymorphisms (SNP) located within the HSF1 and HSPA6 candidate genes for adaptability in Angus breed raised in subtropical climate. Samples of DNA from 20 animals representing extreme phenotypes for adaptability traits were obtained. Sequence variations in the candidate gene
R. Bras. Zootec.. Publicado em: 05/03/2018
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8. Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population
We investigated the influence of apolipoprotein B gene (APOB) variants on the risk of hyperlipidemia (HL) in 631 middle-aged and elderly members of the Chinese Yugur population (HL, n=336; normolipidemia, n=295). APOB polymorphisms were identified using mass spectrometry, and five single nucleotide polymorphisms (rs1042034, rs2163204, rs512535, rs676210, and
Braz J Med Biol Res. Publicado em: 12/09/2017
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9. Human leukocyte antigen allele linkage disequilibrium and haplotype structure in volunteer bone marrow donors of Paraná State
Abstract Background Bone marrow transplantation has been used in the treatment of various diseases, especially hematologic diseases. The success of this treatment, among other factors, requires human leukocyte antigens (HLA) compatibility between patient and donor. Knowing the human leukocyte antigens allele group and haplotype frequencies as well as the li
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-09
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10. Understanding population-wide haplotype frequencies of human leukocyte antigen (HLA) alleles in linkage disequilibrium is important for hematopoietic stem cell transplantation
Rev. Bras. Hematol. Hemoter.. Publicado em: 2017-09
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11. The Identification of SNPs in BCDO2 Gene for Skin Color in Chinese Indigenous Chicken
ABSTRACT A complete linkage disequilibrium between the SNP (SNP B) in BCDO2 gene and the yellow skin phenotype in European domestic chicken has been reported. Here, we genotyped the reported SNPs (SNP A, SNP B, and SNP C) of the BCDO2 gene in 183 Chinese Indigenous chickens from 11 breeds/populations, including 57 yellow, 17 white, and 109 black skin chicken
Rev. Bras. Cienc. Avic.. Publicado em: 2017-09
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12. Genome-wide association study of pre-harvest sprouting resistance in Chinese wheat founder parents
Abstract Pre-harvest sprouting (PHS) is a major abiotic factor affecting grain weight and quality, and is caused by an early break in seed dormancy. Association mapping (AM) is used to detect correlations between phenotypes and genotypes based on linkage disequilibrium (LD) in wheat breeding programs. We evaluated seed dormancy in 80 Chinese wheat founder pa
Genet. Mol. Biol.. Publicado em: 10/07/2017