Lipoperoxidation
Mostrando 1-12 de 36 artigos, teses e dissertações.
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1. Campsiandra laurifolia Reduces Oxidative Stress and Inflammation in Rats with Ulcerative Colitis
Abstract Ulcerative colitis (UC) affects the mucosa and submucosa of the large intestine. One of the mechanisms involved in its etiology is oxidative stress (OS), directly involved in the inflammatory process characteristic of UC. The Campsiandra laurifolia, known as acapurana, was described as possessing antioxidant properties. We used 24 male Wistar rats,
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2022
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2. Chlorophyll treatment combined with photostimulation increases glycolysis and decreases oxidative stress in the liver of type 1 diabetic rats
Photodynamic therapy (PDT) promotes cell death, and it has been successfully employed as a treatment resource for neuropathic complications of diabetes mellitus (T1DM) and hepatocellular carcinoma. The liver is the major organ involved in the regulation of energy homeostasis, and in pathological conditions such as T1DM, changes in liver metabolic pathways re
Braz J Med Biol Res. Publicado em: 2020-01
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3. Evaluation of cell damage and modulation of cytokines TNF-α, IL-6 and IL-10 in macrophages exposed to PpIX-mediated photodynamic therapy
Resumo Pouco se sabe se a morte celular induzida pela terapia fotodinâmica (PDT) compromete os macrófagos (MΦ), envolvidos nas respostas imunes induzidas pela PDT. Neste estudo, foram avaliados parâmetros de citotoxicidade dos MΦ mediada pela PDT e a produção de citocinas, frente à protoporfirina IX (PpIX). MΦ peritoneais de camundongos BALB/c foram
Braz. J. Biol.. Publicado em: 26/09/2019
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4. Melatonin effects on pulmonary tissue in the experimental model of Hepatopulmonary Syndrome
RESUMO Objetivo: Avaliar as alterações pulmonares de animais com Síndrome Hepatopulmonar (SHP), submetidos à ligadura de ducto biliar (LDB), bem como o efeito antioxidante da Melatonina (MEL). Métodos: Dezesseis ratos machos da espécie Wistar, divididos em quatro grupos: Sham, Grupo LDB, Grupo Sham + MEL e LDB + MEL. Foram avaliadas a histologia pulm
J. bras. pneumol.. Publicado em: 30/05/2019
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5. Glutathione depletion triggers actin cytoskeleton changes via actin-binding proteins
Abstract The importance of glutathione (GSH) in alternative cellular roles to the canonically proposed, were analyzed in a model unable to synthesize GSH. Gene expression analysis shows that the regulation of the actin cytoskeleton pathway is strongly impacted by the absence of GSH. To test this hypothesis, we evaluate the effect of GSH depletion via buthion
Genet. Mol. Biol.. Publicado em: 04/06/2018
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6. Physical exercise prevents motor disorders and striatal oxidative imbalance after cerebral ischemia-reperfusion
Stroke is the third most common cause of death worldwide, and most stroke survivors present some functional impairment. We assessed the striatal oxidative balance and motor alterations resulting from stroke in a rat model to investigate the neuroprotective role of physical exercise. Forty male Wistar rats were assigned to 4 groups: a) control, b) ischemia, c
Braz J Med Biol Res. Publicado em: 28/07/2015
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7. Characterization of an alcoholic hepatic steatosis model induced by ethanol and high-fat diet in rats
Alcoholic liver disease is characterized by a wide spectrum of liver damage, which increases when ethanol is associated with high-fat diets (HFD). This work aimed to establish a model of alcoholic hepatic steatosis (AHS) by using a combination of 10% ethanol and sunflower seeds as the source of HFD. Male rats received water or 10% ethanol and regular chow di
Braz. arch. biol. technol.. Publicado em: 06/03/2015
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8. Effect of ozone oxidative preconditioning in preventing early radiation-induced lung injury in rats
Ionizing radiation causes its biological effects mainly through oxidative damage induced by reactive oxygen species. Previous studies showed that ozone oxidative preconditioning attenuated pathophysiological events mediated by reactive oxygen species. As inhalation of ozone induces lung injury, the aim of this study was to examine whether ozone oxidative pre
Braz J Med Biol Res. Publicado em: 27/09/2013
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9. Antioxidant effect of 4-nerolidylcatechol and α-tocopherol in erythrocyte ghost membranes and phospholipid bilayers
4-Nerolidylcatechol (4-NC) is found in Pothomorphe umbellataroot extracts and is reported to have a topical protective effect against UVB radiation-induced skin damage, toxicity in melanoma cell lines, and antimalarial activity. We report a comparative study of the antioxidant activity of 4-NC and α-tocopherol against lipid peroxidation initiated by two fre
Braz J Med Biol Res. Publicado em: 06/09/2013
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10. Pleiotropic effects of simvastatin in physically trained ovariectomized rats
This study tested the hypothesis that simvastatin treatment can improve cardiovascular and autonomic functions and membrane lipoperoxidation, with an increased effect when applied to physically trained ovariectomized rats. Ovariectomized rats were divided into sedentary, sedentary+simvastatin and trained+simvastatin groups (n = 8 each). Exercise training was
Braz J Med Biol Res. Publicado em: 24/05/2013
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11. EFEITO in vitro DE Paullinia cupana NO METABOLISMO OXIDATIVO DE ESPERMATOZÓIDES HUMANOS EXPOSTOS AO CLORETO DE METILMERCÚRIO / EFFECT OF Paullinia cupana in vitro oxidative metabolism HUMAN SPERM EXPOSED TO CHLORIDE METHYLMERCURY
Investigations suggests that methylmercury (MeHg) toxicitiy is related to oxidative stress promotion caused by lipid peroxidation of cell membranes as well as genotoxicity. The methylmercury (MeHg) exposition causes production of adverse effects as deterioration of semen quality, testicular degeneration, and male reproductive failure. Since human sperm is a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/02/2012
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12. Electron paramagnetic resonance study of lipid and protein membrane components of erythrocytes oxidized with hydrogen peroxide
Electron paramagnetic resonance (EPR) spectroscopy of spin labels was used to monitor membrane dynamic changes in erythrocytes subjected to oxidative stress with hydrogen peroxide (H2O2). The lipid spin label, 5-doxyl stearic acid, responded to dramatic reductions in membrane fluidity, which was correlated with increases in the protein content of the membran
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-06