Liposome Production
Mostrando 1-12 de 33 artigos, teses e dissertações.
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1. Secretory TAT-peptide-mediated protein transduction of LIF receptor α-chain distal cytoplasmic motifs into human myeloid HL-60 cells
The distal cytoplasmic motifs of leukemia inhibitory factor receptor α-chain (LIFRα-CT3) can independently induce intracellular myeloid differentiation in acute myeloid leukemia (AML) cells by gene transfection; however, there are significant limitations in the potential clinical use of these motifs due to liposome-derived genetic modifications. To produce
Braz J Med Biol Res. Publicado em: 2012-10
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2. Modificações químicas do ácido hialurônico para a produção de géis reticulados e de fosfolipídios derivatizados / Chemical modification of hyaluronic acid for production of cross-linked gels and derivatized phospholipids
Neste trabalho foram estudadas as reações de modificação química do ácido hialurônico (AH) com divinilsulfona (DVS) para preparação de géis reticulados e com carbodiimidas para preparação de fosfolipídios derivatizados. A modificação com DVS envolve os grupos hidroxílicos do AH, enquanto a modificação mediada por carbodiimida envolve os gru
Publicado em: 2011
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3. Neisseria meningitidis antigens immune response study: toxoid as mice model adjuvant encapsulated in liposomes. / Estudo da imunogenicidade de antígenos de Neisseria meningitidis: utilização de toxóide como adjuvante, vetorizado em lipossomas, no modelo camundongo.
N.meningitidis is diplococcus gram-negative strict human patogen that similarly to other bacteria are surrounded by external membrane with lipids, proteins (OMP) and LPS. It has been one of the main causes of the meningitidis and other invading infections in the world. This work searched to use STX2 toxoid of E.coli as adjuvant for a possible and future vacc
Publicado em: 2008
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4. A mathematical model describing the kinetic of cationic liposome production from dried lipid films adsorbed in a multitubular system
Cationic liposomes are an alternative to DNA non-viral carrier in gene therapy, promoting higher efficiency for transport and delivery into the cells. Liposome production large scale is still a challenge. Among many processes, from dried film adsorbed inside multitubular system promising due its operational simplicity. this field, engineering contributions s
Brazilian Journal of Chemical Engineering. Publicado em: 2007-12
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5. Evaluation of the praziquantel in liposome effect in Schistosoma mansoni in vivo / Avaliação do efeito do praziquantel associado a lipossomas em Schistosoma mansoni in vivo
For the treatment of schistosomiasis mansoni in Brazil, the drugs of choice are Oxamniquina (OXA) and the Praziquantel (PRZ). OXA has its production reduced by its collateral, carcinogenic and mutagenic effects that it presents. PRZ has wide action spectrum and low toxicity, when compared to OXA. However, it has the disadvantage of being eliminated very fast
Publicado em: 2007
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6. Dipropionato de beclometasona em formulação lipossomal como po inalavel para o tratamento de doenças pulmonares
The liposomal drug encapsulation for medical applications is in many instances the most efficient way to ensure good storage, transport, targeting, and controlled release of the drug, thus reducing toxicity. Liposomes have been extensively studied as vehicles for efficient drug delivery. The objective of the present work is to develop a formulation of the co
Publicado em: 2007
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7. Lipid adjuvants as carriers for tuberculosis DNA vaccine / Desenvolvimento de vacina genica veiculada em adjuvantes lipidicos para tratamento da tuberculose
Este trabalho visa o desenvolvimento tecnológico de uma vacina gênica, destinada ao combate à tuberculose, na qual o DNA encontra-se veiculado em lipossomas. Foram enfocados três aspectos principais: 1.A preparação e caracterização de estruturas lipídicas funcionais veiculando o DNA, projetadas para atenderem aos requisitos de imunização contra a
Publicado em: 2006
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8. Preparação e caracterização de lipossomas com a superficie modificada com gangliosidios para uso em imunoterapia
The pharmacological importance of gangliosides has increased in the last few years due to the identification of these compounds as antigens, producing antiganglioside antibodies, which may be involved in autoimmune diseases or neuropathy. Studies in ganglioside literature encompass their properties and functions in the neuronal membranes as well as their pha
Publicado em: 2001
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9. Liposome-mediated delivery of tobacco mosaic virus RNA into tobacco protoplasts: A sensitive assay for monitoring liposome-protoplast interactions
Tobacco mosaic virus (TMV) RNA was encapsulated in large, unilamellar phospholipid vesicles (liposomes), and the encapsulated TMV RNA was shown to be infectious when incubated with tobacco protoplasts under appropriate conditions. Maximal virus production in protoplasts was observed after their incubation with TMV RNA entrapped in phosphatidylserine/choleste
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10. Induction of Protective T Cells against Listeria monocytogenes in Mice by Immunization with a Listeriolysin O-Negative Avirulent Strain of Bacteria and Liposome-Encapsulated Listeriolysin O
Only listeriolysin O (LLO)-producing strains of Listeria monocytogenes generate protective immunity in mice. Based on the findings that endogenous gamma interferon (IFN-γ) production was induced only by such strains and that purified LLO could induce IFN-γ from NK cells, we have postulated that LLO may play a pivotal role in the induction of Th1-type prote
American Society for Microbiology.
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11. In vivo induction of anti-herpes simplex virus immune response by type 1 antigens and lipid A incorporated into liposomes.
To establish the requirements for a potential subunit vaccine against herpes simplex virus (HSV), we analyzed the effects on immunogenicity of incorporating detergent-extracted glycoprotein-enriched HSV type 1 (HSV-1) antigens into liposomes alone or with the adjuvant lipid A. Incorporating HSV-1 antigens into liposomes enhanced their immunogenicity for anti
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12. A distinct basic fibroblast growth factor (FGF-2)/FGF receptor interaction distinguishes urokinase-type plasminogen activator induction from mitogenicity in endothelial cells.
Basic fibroblast growth factor (FGF-2) induces cell proliferation and urokinase-type plasminogen activator (uPA) production in fetal bovine aortic endothelial GM 7373 cells. In the present paper we investigated the role of the interaction of FGF-2 with tyrosine-kinase (TK) FGF receptors (FGFRs) in mediating uPA up-regulation in these cells. The results show