Ly294002
Mostrando 1-12 de 161 artigos, teses e dissertações.
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1. Exenatide ameliorates hepatic steatosis and attenuates fat mass and FTO gene expression through PI3K signaling pathway in nonalcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific
Braz J Med Biol Res. Publicado em: 14/06/2018
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2. Reactive oxygen species generation mediated by NADPH oxidase and PI3K/Akt pathways contribute to invasion of Streptococcus agalactiae in human endothelial cells
BACKGROUND Streptococcus agalactiae can causes sepsis, pneumonia, and meningitis in neonates, the elderly, and immunocompromised patients. Although the virulence properties of S. agalactiae have been partially elucidated, the molecular mechanisms related to reactive oxygen species (ROS) generation in infected human endothelial cells need further investigati
Mem. Inst. Oswaldo Cruz. Publicado em: 05/04/2018
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3. Salvinorin A preserves cerebral pial artery autoregulation after forebrain ischemia via the PI3K/AKT/cGMP pathway
This study aimed to investigate the protective effect of salvinorin A on the cerebral pial artery after forebrain ischemia and explore related mechanisms. Thirty Sprague-Dawley rats received forebrain ischemia for 10 min. The dilation responses of the cerebral pial artery to hypercapnia and hypotension were assessed in rats before and 1 h after ischemia. The
Braz J Med Biol Res. Publicado em: 15/03/2018
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4. The role of histone deacetylase inhibitors in regulation of Akt/GSK-3β signaling pathway in mice following transient focal cerebral ischemia
Abstract Purpose: To investigate whether the neuroprotective effect of TSA on cerebral ischemia reperfusion injury is mediated by the activation of Akt/GSK-3β signaling pathway. Methods: Mice were randomly divided into four groups (n=15): sham group (S); ischemia reperfusion group (IR); ischemia reperfusion and pretreated with TSA group (IR+T); ischemia
Acta Cir. Bras.. Publicado em: 2017-10
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5. Roles of the ERK1/2 and PI3K/PKB signaling pathways in regulating the expression of extracellular matrix genes in rat pulmonary artery smooth muscle cells
Abstract Purpose: To investigate the mechanisms by which PD98059 and LY294002 interfere with the abnormal deposition of extracellular matrix regulated by connective tissue growth factor (CTGF) of rat pulmonary artery smooth muscle cells (PASMCs). Methods: Rat PASMCs were cultured and separated into a control group. Real-time fluorescence quantitative PCR w
Acta Cir. Bras.. Publicado em: 2017-05
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6. Six1 induces protein synthesis signaling expression in duck myoblasts mainly via up-regulation of mTOR
Abstract As a critical transcription factor, Six1 plays an important role in the regulation of myogenesis and muscle development. However, little is known about its regulatory mechanism associated with muscular protein synthesis. The objective of this study was to investigate the effects of overexpression ofSix1 on the expression of key protein metabolism-re
Genet. Mol. Biol.. Publicado em: 2016-03
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7. Efeitos rápidos da triiodotironina no receptor de hormônio tireoidiano alfa pela via PI3K em adipócitos, 3T3-L1
Objetivo O objetivo do presente estudo foi analisar os efeitos do hormônio tireoidiano (HT), triiodotironina (T3), na modulação da expressão de mRNA do receptor alfa (TRα) de HT e o envolvimento da via de sinalização da via fosfatidilinositol 3-quinase (PI3K) em adipócitos, 3T3-L1. Materiais e métodos: Foi examinado o envolvimento da via PI3K nos
Arq Bras Endocrinol Metab. Publicado em: 2014-11
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8. ERKs and mitochondria-related pathways are essential for glycyrrhizic acid-mediated neuroprotection against glutamate-induced toxicity in differentiated PC12 cells
The present study focuses on the neuroprotective effect of glycyrrhizic acid (GA, a major compound separated from Glycyrrhiza Radix, which is a crude Chinese traditional drug) against glutamate-induced cytotoxicity in differentiated PC12 (DPC12) cells. The results showed that GA treatment improved cell viability and ameliorated abnormal glutamate-induced alt
Braz J Med Biol Res. Publicado em: 25/07/2014
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9. Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
Quercetin (Que), a plant-derived flavonoid, has multiple benefical actions on the cardiovascular system. The current study investigated whether Que postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. Male Sprague-Dawley rats were randomly allocated to 5 groups (20
Braz J Med Biol Res. Publicado em: 24/09/2013
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10. ESTUDO DOS MECANISMOS ENVOLVIDOS NO AUMENTO DA BIODISPONIBILIDADE DE ÓXIDO NÍTRICO EM ARTÉRIA FEMORAL DE RATOS SUBMETIDOS AO TREINAMENTO FÍSICO / Study of the mechanisms involved in increased nitric oxide bioavailability in femoral artery of rats submitted to physical training
O treinamento físico (TF) é um estilo de vida benéfico para o condicionamento do sistema cardiovascular. Porém, os mecanismos pelo quais o TF atua nas células vasculares e induz ajustes que melhoram a sua função ainda precisam ser melhor elucidados. Assim, a presente dissertação objetivou estudar o efeito do TF de baixa intensidade sobre os mecanism
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/08/2012
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11. Regulation of hypoxia-inducible factor-1α (HIF-1α) expression by interleukin-1β (IL-1 β), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes
OBJECTIVE: Hypoxia-inducible factor 1 alpha regulates genes related to cellular survival under hypoxia. This factor is present in osteroarthritic chondrocytes, and cytokines, such as interleukin-1 beta, participate in the pathogenesis of osteoarthritis, thereby increasing the activities of proteolytic enzymes, such as matrix metalloproteinases, and accelerat
Clinics. Publicado em: 2012
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12. Modulação do metabolismo muscular da glicose pela ação hipotalâmica da leptina / Modulation of glucose metabolism in muscle by the leptin hypothalamic action
Sobrepeso e obesidade são caracterizados por um aumento de tecido adiposo corpóreo, que resulta da interação entre muitos fatores, incluindo genéticos, metabólicos, comportamentais e ambientais. A obesidade está relacionada ao desenvolvimento de diabetes mellitus do tipo 2 (DM2). O principal mecanismo envolvido na associação entre obesidade e DM2 é
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/08/2011