Memory Immune Response
Mostrando 1-12 de 224 artigos, teses e dissertações.
-
1. Immunosenescence: participation of T lymphocytes and myeloid-derived suppressor cells in aging-related immune response changes
RESUMO O envelhecimento saudável está relacionado, pelo menos em parte, com a função adequada do sistema imunológico. Isso porque já foi relatado que, com o envelhecimento, algumas mudanças desse sistema são observadas, como a diminuição da percentagem e do repertório de células T pela involução tímica, acúmulo de células T de memória por i
Einstein (São Paulo). Publicado em: 02/05/2019
-
2. B cells expressing IL-10 mRNA modulate memory T cells after DNA-Hsp65 immunization
In DNA vaccines, the gene of interest is cloned into a bacterial plasmid that is engineered to induce protein production for long periods in eukaryotic cells. Previous research has shown that the intramuscular immunization of BALB/c mice with a naked plasmid DNA fragment encoding the Mycobacterium leprae 65-kDa heat-shock protein (pcDNA3-Hsp65) induces prote
Braz J Med Biol Res. Publicado em: 18/09/2015
-
3. T-cell receptor Vβ repertoire of CD8+ T-lymphocyte subpopulations in cutaneous leishmaniasis patients from the state of Rio de Janeiro, Brazil
In human cutaneous leishmaniasis (CL), the immune response is mainly mediated by T-cells. The role of CD8+ T-lymphocytes, which are related to healing or deleterious functions, in affecting clinical outcome is controversial. The aim of this study was to evaluate T-cell receptor diversity in late-differentiated effector (LDE) and memory CD8+ T-cell subsets in
Mem. Inst. Oswaldo Cruz. Publicado em: 24/06/2015
-
4. Decreased memory T-cell response and function in human immunodeficiency virus-infected patients with tegumentary leishmaniasis
The effects of human immunodeficiency virus (HIV) on the immune response in patients with cutaneous leishmaniasis have not yet been fully delineated. This study quantified and evaluated the function of memory T-cell subsets in response to soluble Leishmania antigens (SLA) from patients coinfected with HIV and Leishmania with tegumentary leishmaniasis (TL). E
Mem. Inst. Oswaldo Cruz. Publicado em: 02/10/2013
-
5. Papel de SOCS2 na resposta imune e função cardíaca durante a infecção experimental por Trypanosoma cruzi
Infection with Trypanosoma cruzi induces robust inflammation that limits parasite proliferation but may result in Chagas heart disease. The 5-Lipoxygenase pathway induces suppressor of cytokine signaling(SOCS)2 expression, an important regulator of immune responses. Here, we investigated the role of SOCS2 for the pathogenesis of T. cruzi infection. We invest
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/12/2011
-
6. Produção e caracterização do anticorpo monoclonal aDEC205 acoplado a proteína MSP-1 (19) de Plasmodium chabaudi. / Production and characterization of a monoclonal antibody aDEC205 coupled to MSP-1(19) protein from Plasmodium chabaudi.
Despite the strong activation of the immune system that occurs during infection by Plasmodium, the immunological memory to infection is restricted to patients residing in endemic areas. Thus it is important to the generation of methods to induce an effective immune response against the parasite. In this context, the targeting of antigens to the central cells
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/05/2011
-
7. Perfil de memória e ativação de linfócitos T na leishmaniose visceral
A Leishmaniose visceral (LV) nas Américas é uma doença causada pela espécie Leishmania infantum chagasi (L.i.chagasi). A forma clínica evolutiva pós-infecção depende da resposta imune do hospedeiro vertebrado, que é geneticamente mediada. Este estudo teve como objetivo avaliar a resposta imune de indivíduos residentes em área endêmica para LV no
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/12/2010
-
8. Etiology and immunology of infectious bronchitis virus
Infectious bronchitis virus (IBV) of chickens is currently one of the main diseases associated with respiratory syndrome in domestic poultry, as well as with losses related to egg production. The etiological agent is a coronavirus, which presents structural differences in the field, mainly in the S1 spike protein. The immune response against this virus is co
Revista Brasileira de Ciência Avícola. Publicado em: 2010-06
-
9. Caracterização fenotípica e funcional de linfócitos T de memória de indivíduos infectados pelo HIV reativos a epitopos T CD4+ derivados de sequências do consenso B do HIV-1 / Phenotypic and functional characterization of memory T lymphocytes from HIV infected individuals reactive to CD4-T epitopes derived from sequences of the HIV-1 B consensus
The persistence of functional memory T cell is important to ensure a protective immunity to Human Immunodeficiency Virus (HIV) infection. Memory T cells have been subdivided into central memory (TCM), effector memory (TEM) and highly differentiated effector memory (TEMRA) based on the expression of surface molecules such as CCR7 and CD45RA, and the ability t
Publicado em: 2010
-
10. A função da IL-10 na paracoccidioidomise pulmonar murina. / The role of IL-10 in murine pulmonary paracoccidioidomycosis.
Cellular immunity is the main defense mechanism of hosts infected by the Paracoccidioide brasiliensis (Pb), a dimorphic fungus that causes the most important systemic mycosis in Latin America. IFN-g activated macrophages participate in this activity that is antagonized by IL-10 an anti-inflammatory cytokine. Both, in the human pathology a
Publicado em: 2010
-
11. Protective immunity against Trypanosoma cruzi
Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed. Emphasis is placed on recent studies of the important protective role of CD8+ T cells and on previous studies of immunisation of domestic T. cruzi res
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-07
-
12. Imunogenicidade da vacina de DNA quimérica LAMP-1/p55Gag do HIV-1 no período neonatal e efeito da imunização materna na resposta vacinal da prole de camundongos. / Immunogenicity of LAMP-1/p55Gag of HIV-1 DNA chimeric vaccine on neonatal period and effect of maternal immunization immune response of vaccinated offspring.
The immunogenicity of LAMP/gag DNA vaccine of HIV-1, which target the antigen to the class II MHC compartment, was evaluated on BALB/c neonate mice and also the effect of maternal immunization on off spring vaccine response was analyzed. The LAMP/gag neonatal vaccination elicited IgG antibody anti-Gag production and augment the IFN-g producing cells to the M
Publicado em: 2009