Micellar Electrokinetic Chromatography
Mostrando 1-12 de 13 artigos, teses e dissertações.
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1. Development of a method for simultaneous analysis of caffeine and taurine in energy drinks by micellar electrokinetic chromatography with diode-array detector
Abstract The objective of this study was to develop, optimize and validate a fast and reliable method for the simultaneous determination of caffeine and taurine contents by micellar electrokinetic chromatography with diode array detector, using direct and indirect detection concomitantly. Multivariate statistical techniques were used as a central composite d
Food Sci. Technol. Publicado em: 16/09/2019
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2. Simultaneous determination of atorvastatin and ezetimibe from combined pharmaceutical products by micellar electrokinetic capillary chromatography
Abstract A rapid and sensitive micellar electrokinetic capillary chromatography method with UV photodiode-array detection was developed for the simultaneous determination of atorvastatin and ezetimibe in fixed dose drug combination. Experimental conditions such as buffer concentration and pH, surfactant concentration, system temperature, applied voltage, inj
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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3. FUNDAMENTOS DE ELETROFORESE CAPILAR: UMA ABORDAGEM POR ANIMAÇÕES
Among the analytical separation techniques, capillary electrophoresis (CE) has attracted attention in both academic and industrial fields, mainly owing to its efficiency, short analysis times, low reagent consumption and residue generation. This is also the case in Chemistry courses, books and papers, demonstrating CE´s well-established status. However,
Quím. Nova. Publicado em: 2015-06
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4. Optimization of an Electrolyte System for the Simultaneous Separation of Nelfinavir Mesylate and Two Impurities by Micellar Electrokinetic Chromatography
A methodology for the simultaneous determination of nelfinavir mesylate and the impurities 3-hydroxy-2-methylbenzoic acid and (2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl) octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate by micellar electrokinetic chromatography, with an analysis time of 25 min, was proposed. An electrolyte c
J. Braz. Chem. Soc.. Publicado em: 2015-05
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5. Simultaneous separation of ciprofloxacin, norfloxacin and ofloxacin by micellar electrokinetic chromatography
Este trabalho descreve o desenvolvimento de um método simples de eletroforese capilar (EC) para determinação simultânea dos três derivados mais frequentemente usados da fluoroquinolona: ciprofloxacina, norfloxacina e ofloxacina. Devido às características estruturais e físico-químicas muito semelhantes, ciprofloxacina e norfloxacina não podem ser se
J. Braz. Chem. Soc.. Publicado em: 26/10/2012
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6. Estratégias de pré-concentração em eletroforese capilar: parte 2. Manipulação da velocidade da fase dispersa/secundária
This work describes CE preconcentration strategies based on the effect of manipulation of the disperse/secondary velocity. Introduced by Terabe et al. in 1984, micellar electrokinetic chromatography is a powerful separation approach that increases the usage of electrokinetic phenomena for the separation of nonionic compounds. The main disadvantage of MEKC is
Química Nova. Publicado em: 2010
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7. Olmesartana medoxomila : validação de metodologia analítica, avaliação biofarmacêutica e análise polimórfica / Olmesartan medoxomil: validation of analytical methodology, biopharmaceutical evaluation, and polymorphic analysis
O pró-fármaco olmesartana medoxomila (OLM) é um anti-hipertensivo representante da classe dos bloqueadores seletivos dos receptores da angiotensina II (BRA). No Brasil, encontra-se disponível sob a forma de comprimidos revestidos (Benicar®). Foi aprovado pelo FDA em 2002. Não existe monografia disponível para este fármaco em nenhum código oficial. D
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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8. DEVELOPMENT AND VALIDATION OF METHODOLOGY FOR THE EVALUATION OF RUPATADINE BY LIQUID CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS / DESENVOLVIMENTO E VALIDAÇÃO DE METODOLOGIA PARA AVALIAÇÃO DE RUPATADINA POR CROMATOGRAFIA LÍQUIDA E ELETROFORESE CAPILAR
Rupatadine is a second generation antihistamine H1, from the pyperidinic group, which inhibits both the histamine and platelet activating factor effects, and is clinically used for the treatment of allergic rhinitis and chronic urticaria. The methods for the evaluation of rupatadine in pharmaceutical products were developed and validated in the present work.
Publicado em: 2009
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9. DEVELOPMENT AND VALIDATION OF METHODOLOGY FOR THE EVALUATION OF FLUTICASONE BY LIQUID CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS / DESENVOLVIMENTO E VALIDAÇÃO DE METODOLOGIA PARA AVALIAÇÃO DE FLUTICASONA POR CROMATOGRAFIA LÍQUIDA E ELETROFORESE CAPILAR
Fluticasone propionate (FP) is a synthetic glucocorticoid with potent anti-inflammatory activity that has been effectively used for the treatment of seasonal and allergic perennial rhinitis, minimizing systemic activity. In the present study, the methods were developed and validaded for assessment of FP in pharmaceutical products. The analysis by reversed-ph
Publicado em: 2009
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10. Heavy atom enhanced room-temperature phosphorimetry for ultratrace determination of harmane
Harmane has been proposed for the treatment of epilepsy, AIDS and leshmaniosis. Its room-temperature phosphorescence was induced using either AgNO3 or TlNO3, enabling absolute limits of detection of 0.12 and 2.4 ng respectively, with linear dynamic ranges extending up to 456 ng (AgNO3) and 911 ng (TlNO3). Relative standard deviations around 3% were observed
Química Nova. Publicado em: 2008
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11. Evaluation of biological potential of natural piperolídeos of Piper malacophyllum (C. Presl) C. DC. and synthetic analogues / Avaliação do pontencial biológico de piperolídeos naturais de Piper malacophyllum (C. Presl) C. DC. e de análogos sintéticos
Based on the powerful antifungal activity of piperolides (1 e 2) isolated from Piper malacophyllum leaves extracts, several analogues were synthesized aiming at establishing preliminary structure-activity relationship against Cladosporium cladosporioides, C. sphaerospermum and against epimastigote form of Trypanosoma cruzi. Phytochemical studies carried out
Publicado em: 2008
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12. "Study of Sapindus saponaria fruit?s extracts rich on saponins and other glycosides and their application in capillary electrophoresis" / "Estudo dos extratos dos frutos de Sapindus saponaria enriquecidos em saponinas e outros glicosídeos e sua aplicação em eletroforese capilar"
Sapindus saponaria is a very abundant species in São Carlos and others regions of Brazil. Fruits of S. saponaria have a high content of glycosides which possess well-defined regions of hydrophobic and hydrophilic feature denominated amphiphilic molecule. Thus, this can form a foam showing chemical proprieties equals to surfactants. Some glycosides belong to
Publicado em: 2006