Migrastatin
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Synthesis and pharmacological evaluation of structural analogues of the macrolactone of migrastatin / Síntese e avaliação farmacológica de análogos estruturais da macrolactona da migrastatina
A macrolactona da migrastatina 10 é um composto que apresenta alta atividade de inibição de migração de células tumorais in vitro dentre os compostos da família da migrastatina. Em 2002, Licari e colaboradores relataram um novo composto chamado de isomigrastatina 14, onde alguns anos depois, Shen e colaboradores relataram que este composto faz parte d
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/07/2012
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2. Sintese da macrolactona da migrastatina e analogo : sinteses e aplicações de novos substratos em reações de RCAM catalisadas por [Mo] / Synthesis of the macrolactone of migrastatin and analog : syntheses of new substrates for applications in Mo-catalyzed RCAM
Chapter 1 describes the syntheses of macrolactones 11 and 62a. Macrolactone 11 presents the best tumor cell migration inhibitory effect among the compounds of the migrastatin family synthesized so far. Macrolactone 62a, not described in the literature, is the C8-epimer of macrolactone 62b, which was synthesized by Professor Danishefskys group in 2004 and s
Publicado em: 2009
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3. Synthesis of the C1-C13 fragment of migrastatin / Sintese do fragmento C1-C13 da migrastatina
Migrastatin was isolated from a cultured broth of Streptomyces sp. MK929-43F1 in 2000 by Imoto and co-workers, as well as from a cultured broth of Streptomyces platensis NRRL 18993 by researchers from Kosan Biosciences. Migrastatin has a remarkable inhibitory effect on the migration of human tumor cells, very important to the tumor metastasis treatment. Its
Publicado em: 2005
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4. iso-Migrastatin, Migrastatin, and Dorrigocin Production in Streptomyces platensis NRRL 18993 Is Governed by a Single Biosynthetic Machinery Featuring an Acyltransferase-less Type I Polyketide Synthase*
iso-Migrastatin and related glutarimide-containing polyketides are potent inhibitors of tumor cell migration and their implied potential as antimetastatic agents for human cancers has garnered significant attention. Genome scanning of Streptomyces platensis NRRL 18993 unveiled two candidate gene clusters (088D and mgs); each encodes acyltransferase-less type
American Society for Biochemistry and Molecular Biology.
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5. Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice
Tumor metastasis is the most common cause of death in cancer patients. Here, we show that two, fully synthetic migrastatin analogues, core macroketone and core macrolactam, are potent inhibitors of metastasis in a murine breast tumor model. Administration of these readily accessible compounds nearly completely inhibits lung metastasis of highly metastatic ma
National Academy of Sciences.