Mitotane
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Separação cromatografica quiral do o,p -diclorodifenildicloroetano (mitotano) em fase estacionaria quiral O,O bis[4-terc-butilbenzoil]-N,N dialil-L-tartadiamida / Chiral chromatographic separation of the o,p -dichlorodiphenyldichloroethane (mitotane) using chiral stationary phase O,O -bis{4-terc-butylbenzoyl]-N,N -diallyl-L-tartardiamide
O mitotano (o,p?-diclorodifenildicloroetano) é um fármaco utilizado no tratamento de carcinoma adrenocortical. Ele é comercializado na forma racêmica, ou seja, na proporção 1:1 dos seus enantiômeros R e S. A influência da quiralidade da molécula sobre seu efeito farmacológico ainda não foi estudada. Portanto, a separação dos enantiômeros é imp
Publicado em: 2007
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2. Papel da terapia medicamentosa na síndrome de Cushing
A terapêutica cirúrgica continua, até o momento, a ser considerada a principal, para a síndrome de Cushing endógena, qualquer que seja a causa. Entretanto em certas circunstâncias, como preparo pré-cirúrgico, ausência de cura após a cirurgia ou impossibilidade cirúrgica, a terapêutica medicamentosa tem papel importante. As drogas que inibem a est
Arquivos Brasileiros de Endocrinologia & Metabologia. Publicado em: 2003-08
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3. Conventional and novel strategies in the treatment of adrenocortical cancer
Adrenocortical carcinoma is a highly malignant neoplasm with an incidence of two per million people per year. Several treatment strategies have resulted in temporary or partial tumor regression but very few cases have attained long survival. Surgical resection of the primary tumor and metastases is most effective. Several chemotherapeutic protocols have been
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-10
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4. Clinical results of the use of mitotane for adrenocortical carcinoma
Mitotane (o,p'-DDD) acts mainly as an inhibitor of intramitochondrial pregnenolone and cortisol synthesis. Its adrenolytic effect depends on metabolic activation due to conversion to o,p'-DDA and o,p'-DDE. The drug has been used for 40 years in the treatment of adrenocortical carcinoma, mainly its regional and metastatic stage, as an adjuvant to surgical res
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-10
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5. Adrenocortical tumors in children
Childhood adrenocortical tumors (ACT) are rare. In the USA, only about 25 new cases occur each year. In Southern Brazil, however, approximately 10 times that many cases are diagnosed each year. Most cases occur in the contiguous states of São Paulo and Paraná. The cause of this higher rate has not been identified. Familial genetic predisposition to cancer
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-10
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6. Management of Endocrine Manifestations and the Use of Mitotane As a Chemotherapeutic Agent for Adrenocortical Carcinoma
Adrenal cortical carcinoma (ACC) is a rare malignancy in which patients have poor overall 5-year survival. Patients with ACC can present with symptoms of hormone excess, including Cushing's syndrome, virilization, feminization, or—less frequently—hypertension with hypokalemia. In many patients with ACC, advanced disease at presentation precludes surgery
American Society of Clinical Oncology.