Molecular Alterations
Mostrando 1-12 de 804 artigos, teses e dissertações.
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1. Genital ulcers caused by sexually transmitted agents,
Abstract Genital ulcers (GUs) represent a diagnostic challenge and can be secondary to neoplastic and inflammatory processes of different causes. Among those of infectious etiology, there are sexually transmitted infections (STIs), a very frequent reason for seeking the health service. The most common agents are herpes simplex virus and Treponema pallidum an
Anais Brasileiros de Dermatologia. Publicado em: 2022
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2. Ayahuasca prevents oxidative stress in a rat model of depression elicited by unpredictable chronic mild stress
ABSTRACT Background: Depression is a highly disabling common mental disorder and, due to its multifactorial nature, the development of effective therapies is challenging and of great relevance. Ayahuasca (AYA), an entheogenic traditional beverage, has emerged as an alternative for antidepressant treatment, however, AYA preclinical and clinical trials are st
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2021-04
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3. ESQUARAÍNAS CIS E TRANS SUBSTITUÍDAS: APLICAÇÃO EXPERIMENTAL DA TEORIA DE GRUPO EM ESPECTROSCOPIA VIBRACIONAL
This work shows a practical application of the group theory to a relatively simple molecular system, as well its impact in the results obtained through vibrational spectroscopic techniques. Squaraines substituted by dicyanemethylene groups have been extensively studied, and after minor approaches in the sense to facilitate the point group determination, they
Quím. Nova. Publicado em: 05/12/2019
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4. Peritonite piogranulomatosa por Nocardia concava em cão - relato de caso
RESUMO Nocardiose é causada por bactérias do gênero Nocardia do subgrupo Actinomycetos, que são Gram-positivas aeróbicas, filamentosas e podem apresentar ramificações. O diagnóstico baseia-se na presença de lesão inflamatória, com o microrganismo morfologicamente compatível, associada ao isolamento e à identificação microbiológica e molecular
Arq. Bras. Med. Vet. Zootec.. Publicado em: 28/10/2019
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5. Mechanisms and biomarker candidates in pterygium development
RESUMO A patogênese do pterígio tem sido relacionada, prin cipalmente, à exposição à luz ultravioleta, mas esta asso ciação permanece bastante controversa. O mecanismo completo do pte rígio também permanece por esclarecer. Fatores como inflamação, infecção viral, estresse oxidativo, metilação do DNA, mediadores inflamatórios, moduladores de
Arq. Bras. Oftalmol.. Publicado em: 30/09/2019
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6. Physiological and Molecular Responses in Rice, Weedy Rice and Barnyardgrass Exposed to Supra-Optimal Temperatures
RESUMO: A temperatura média global pode aumentar de 0,3 a 4,8 oC até o final do século. Temperaturas supraótimas podem afetar as plantas em diferentes níveis organizacionais, causando alterações morfológicas, fisiológicas, bioquímicas e na expressão de genes, e plantas de arroz, arroz-vermelho e capim-arroz tendem a responder de forma distinta qua
Planta daninha. Publicado em: 10/06/2019
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7. Molecular characterization of virulence genes cctA, nanA, and fliC in Clostridium chauvoei from Rio Grande do Sul and São Paulo State, Brazil
RESUMO: Toxina A de Clostridium chauvoei (CctA), neuraminidase (NanA) e flagelina (FliC) são proteínas que contribuem para a patogenicidade de Clostridium chauvoei, o agente causador do carbúnculo sintomático em bovinos. O objetivo deste estudo foi analisar a variabilidade genética dos genes cctA, nanA, e fliC em C. chauvoei isolados em diferentes per�
Cienc. Rural. Publicado em: 02/05/2019
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8. BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells
Abstract Background: The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) have demonstrated innumerous biological effects and pharmacological potential against different cancer types. Hepatocellular carc
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/03/2019
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9. Association of FOSL1 copy number alteration and triple negative breast tumors
Abstract Copy number alterations (CNAs) are a frequent feature in human breast cancer, and one of the hallmarks of genomic instability. The FOSL1, GSTP1 and CCND1 genes are located at 11q13, a cytoband commonly affected by CNA in breast cancer, with relevant function in progression and invasion. Our main goal was to analyze CNAs of these genes and determine
Genet. Mol. Biol.. Publicado em: 28/02/2019
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10. Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties
Abstract For the past 80 years, Crotoxin has become one of the most investigated isolated toxins from snake venoms, partially due to its major role as the main toxic component in the venom of the South American rattlesnake Crotalus durissus terrificus. However, in the past decades, progressive studies have led researchers to shift their focus on Crotoxin, op
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/01/2019
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11. Systematic molecular analysis of hemophilia A patients from Colombia
Abstract Hemophilia A (HA) is an X-linked recessive disorder and the second most common coagulation disorder with an incidence of 1 in 5,000 live born males. Worldwide, there are 178,500 affected individuals, 60% with the severe form of the disease. Intron 22 and 1 inversions (Inv22 and Inv1) are the most frequent molecular alterations found in severe HA pat
Genet. Mol. Biol.. Publicado em: 14/11/2018
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12. A rare case of deafness and renal abnormalities in HDR syndrome caused by a de novo mutation in the GATA3 gene
Abstract HDR syndrome is a rare autosomal dominant disorder caused by mutations in the GATA3 gene and characterized by hypoparathyroidism, sensorineural deafness and renal abnormalities. Here we report a Brazilian family, from which the proband, his mother and his grandfather were diagnosed with bilateral sensorineural hearing loss. Molecular screening of th
Genet. Mol. Biol.. Publicado em: 14/11/2018