Morris Water Maze
Mostrando 1-12 de 85 artigos, teses e dissertações.
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1. Oxiracetam ameliorates cognitive deficits in vascular dementia rats by regulating the expression of neuronal apoptosis/autophagy-related genes associated with the activation of the Akt/mTOR signaling pathway
Oxiracetam (ORC) is a commonly used nootropic drug for improving cognition and memory impairments. The therapeutic effect and underlying mechanism of ORC in vascular dementia (VaD) treatment remain unknown. In this study, 3-month-old male Sprague-Dawley rats with permanent bilateral common carotid artery occlusion-induced VaD were treated orally with low (10
Braz J Med Biol Res. Publicado em: 07/11/2019
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2. INFLUENCE OF ACUTE PHYSICAL EXERCISE ON COGNITIVE AND MOTOR BEHAVIOR IN AN EXPERIMENTAL MODEL OF ALZHEIMER'S DISEASE
RESUMO Introdução: O envelhecimento causa alterações de diversas funções executivas e cognitivas, principalmente relacionadas à incidência de demências, em especial, a doença Alzheimer (DA). Diversos estudos mencionam o exercício físico como um recurso preventivo de sintomas de depressão. Objetivo: Investigar as alterações cognitivas e compo
Rev Bras Med Esporte. Publicado em: 2019-04
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3. ESTUDO DO L-TRIPTOFANO NA DEPRESSÃO OCORRIDA PELA DOENÇA DE ALZHEIMER EM MODELO EXPERIMENTAL
RESUMO O Alzheimer é uma doença neurodegenerativa caracterizado pelo comprometimento cognitivo comumente associado a transtornos do humor, os quais desencadeiam reações depressivas, comprometem o desempenho mental e a funcionalidade. O objetivo do presente estudo foi verificar os efeitos do L-triptofano e analisar o comportamento motor em modelo experime
J. Phys. Educ.. Publicado em: 26/10/2017
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4. Chronic intermittent exposure to ayahuasca during aging does not affect memory in mice
The Quechua term ayahuasca refers to a beverage obtained from decoctions of the liana Banisteriopsis caapi with leaves of Psychotria viridis. The ritualistic use of ayahuasca is becoming a global phenomenon, with some individuals using this beverage throughout life, including in old age. Cognitive impairment is a common manifestation during aging. There are
Braz J Med Biol Res. Publicado em: 05/06/2017
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5. An ontogenic study of the behavioral effects of chronic intermittent exposure to ayahuasca in mice
Ayahuasca is a beverage obtained from decoctions of the Banisteriopsis caapi plus Psychotria viridis. In religious contexts, ayahuasca is used by different age groups. However, little is known of the effects of ayahuasca during ontogenic development, particularly with regard to the functional characteristics of the central nervous system. Animal models are u
Braz J Med Biol Res. Publicado em: 05/06/2017
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6. Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice
Down syndrome cell adhesion molecule (DSCAM) is located within the Down syndrome critical region of chromosome 21. DSCAM is a broadly expressed neurodevelopmental protein involved in synaptogenesis, neurite outgrowth, and axon guidance. We previously demonstrated DSCAM overexpression in the cortex of amyloid precursor protein (APP) transgenic mice, suggestin
Braz J Med Biol Res. Publicado em: 15/05/2017
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7. Effects of hyperbaric oxygen and nerve growth factor on the long-term neural behavior of neonatal rats with hypoxic ischemic brain damage
Abstract Purpose: To evaluate the effects of HBO (Hyperbaric oxygen) and NGF (Nerve growth factor) on the long-term neural behavior of neonatal rats with HIBD (Neonatal hypoxic ischemic brain damage). Methods: The HIBD model was produced by ligating the right common carotid artery of 7 days old SD (Sprague-Dawley) rats followed by 8% O2 + 92% N2 for 2h. To
Acta Cir. Bras.. Publicado em: 2017-04
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8. GABAergic effect of valeric acid from Valeriana wallichii in amelioration of ICV STZ induced dementia in rats
ABSTRACT Valeriana wallichii DC., Caprifoliaceae, is used to have anti-ulcer, anti-spasmodic, anti-epileptic, memory enhancer, anti-anxiety, anti-rheumatic, sedative, anti-asthmatic and diuretic activities. V. wallichii is reported to contain valpotriates, valeric acid, valerenic acid, valechlorine, valerianine, resins and alkaloids. Valeric acid, found in V
Rev. bras. farmacogn.. Publicado em: 2016-08
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9. Enduring amnesia induced by ICV scopolamine is reversed by sesame oil in male rats
ABSTRACT PURPOSE: To evaluated the long-term effect of scopolamine and sesame oil on spatial memory. METHODS: Memory impairment induced by Intracerebroventricular (ICV) injection of scopolamine hydrochloride (10 μg/ rat). Animals were gavaged for 4 weeks with saline, sesame oil (0.5, 1, or 2 mL/kg/day), or 3 weeks with memantine (30 mg/kg/day) in advance
Acta Cir. Bras.. Publicado em: 2016-08
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10. Behavioral alterations induced by repeated saxitoxin exposure in drinking water
Abstract Background Blooms of the saxitoxin-producing cyanobacterium Cylindrospermopsis raciborskii have been contaminating drinking water reservoirs in Brazil for many years. Although acute effects of saxitoxin intoxication are well known, chronic deleterious outcomes caused by repeated saxitoxin exposure still require further investigation. The aim of th
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 14/06/2016
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11. Antioxidant Activity of Oral Administration of Rosmarinus Officinalis Leaves Extract on Rat's Hippocampus which Exposed to 6-Hydroxydopamine
Carnosic acid, a diterpene of Rosemarinus officinalis leaves extract (RE), has potent antioxidant activity in vitro. The dopaminergic connection of substantia nigra pars compacta to the hippocampus might be affected by oxidative stress which caused cognitive impairment observed in the early phase of Parkinson's disease (PD). Adult male Wistar rats were lesio
Braz. arch. biol. technol.. Publicado em: 29/04/2016
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12. Puerarin protects against damage to spatial learning and memory ability in mice with chronic alcohol poisoning
We evaluated the effect of puerarin on spatial learning and memory ability of mice with chronic alcohol poisoning. A total of 30 male C57BL/6 mice were randomly divided into model, puerarin, and control groups (n=10 each). The model group received 60% (v/v) ethanol by intragastric administration followed by intraperitoneal injection of normal saline 30 mi
Braz J Med Biol Res. Publicado em: 27/03/2015