Mt Antigen
Mostrando 1-12 de 125 artigos, teses e dissertações.
-
1. Alzheimer's disease: is a vaccine possible?
The cause of Alzheimer's disease is still unknown, but the disease is distinctively characterized by the accumulation of β-amyloid plaques and neurofibrillary tangles in the brain. These features have become the primary focus of much of the research looking for new treatments for the disease, including immunotherapy and vaccines targeting β-amyloid in the
Braz J Med Biol Res. Publicado em: 2014-06
-
2. Seroreactivity to new Mycobacterium leprae protein antigens in different leprosy-endemic regions in Brazil
New Mycobacterium leprae protein antigens can contribute to improved serologic tests for leprosy diagnosis/classification and multidrug therapy (MDT) monitoring. This study describes seroreactivity to M. leprae proteins among participants from three highly endemic leprosy areas in Brazil: central-western Goiânia/Goiás (GO) (n = 225), Rondonópolis/Mato Gro
Mem. Inst. Oswaldo Cruz. Publicado em: 2012-12
-
3. Análise da expressão de MMP-2, MMP-9, MT1-MMP (MMP-14), TIMP-1, TIMP-2, RECK, TGF-Beta e interleucina-8 em câncer de próstata / Expression of MMP-2, MMP-9, MT1-MMP (MMP-14), TIMP-1, TIMP-2, RECK, TGF-Beta e Interleucina-8 genes in the prostate cancer
Introdução: O câncer de próstata (CaP) é o tumor mais freqüente do homem no Brasil tendo sido estimados mais de 52.350 novos casos em 2010, sendo a segunda causa de óbito por câncer em homens. O prognóstico depende fundamentalmente dos níveis séricos de Prostatic Specific Antigen (PSA) estádio tumoral (TNM) e grau de diferenciação histológica
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/09/2011
-
4. Evaluation of Lionex TB kits and mycobacterial antigens for IgG and IgA detection in cerebrospinal fluid from tuberculosis meningitis patients
To evaluate commercial Lionex TB together with four antigens of Mycobacterium tuberculosis (MPT-64, MT10.3, 16 kDa and 38 kDa) for IgG and IgA cerebrospinal fluid (CSF) detection in the diagnosis of tuberculosis meningitis (TBM) with CSF negative acid-fast bacilli staining, 19 cases of TBM, 64 cases of other infectious meningoencephalitis and 73 cases of oth
Mem. Inst. Oswaldo Cruz. Publicado em: 2010-08
-
5. Comparative evaluation of phenol and thimerosal as preservatives for a candidate vaccine against American cutaneous leishmaniasis
For decades thimerosal has been used as a preservative in the candidate vaccine for cutaneous leishmaniasis, which was developed by Mayrink et al. The use of thimerosal in humans has been banned due to its mercury content. This study addresses the standardization of phenol as a new candidate vaccine preservative. We have found that the proteolytic activity w
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-02
-
6. Demography, genetic diversity, and population relationships among Argentinean Mapuche Indians
Fertility, mortality and migration data from four Mapuche Indian communities located along a 215-km NE-SW linear area in the Province of Río Negro, Argentina, were collated with genetic information furnished by nine blood group systems and by mtDNA haplogroups. The demographic and genetic data indicated a clear dichotomy, which split the four populations in
Publicado em: 2010
-
7. Screening and functional analysis of genes regulated by MT Polyoma Virus antigen in the malign transformation of Balb-3T3 cell line / Busca e identificação de genes regulados pelo Antígeno MT do vírus Polioma na transformação maligna de células Balb-3T3
O Vírus Polioma (Py), induz a formação de múltiplos tumores em camundongos, e causa transformação maligna em cultura, levando à menor dependência de soro e ancoragem para crescimento. Dentre as proteínas codificadas pelo vírus polioma, o antígeno MT (Middle T), isoladamente, é capaz de transformar linhagens celulares imortalizadas e gerar tumores
Publicado em: 2007
-
8. Polyoma middle-sized T antigen can be phosphorylated on tyrosine at multiple sites in vitro.
The polyoma middle-sized T antigen (MT antigen) is associated with a protein kinase activity which phosphorylates tyrosine residues in polyoma T antigens in vitro. We have studied the sites of tyrosine phosphorylation of MT antigens phosphorylated in immunoprecipitates or in soluble form after partial purification by immunoaffinity chromatography. By analyzi
-
9. N-terminal amino acid sequences of the polyoma middle-size T antigen are important for protein kinase activity and cell transformation.
We constructed deletion mutations which removed N-terminal coding sequences of various lengths from a cloned polyoma middle-size T antigen (MT antigen) gene. We introduced the MT antigen genes into a simian virus 40 expression vector so that they were expressed at high levels under the control of the simian virus 40 late promoter in COS-1 cells. The deletion
-
10. Characterization of viable mutants of polyomavirus cold sensitive for maintenance of cell transformation.
We mutagenized a cloned fragment of polyoma DNA encoding portions of the middle size (MT) and large T antigens. We regenerated infectious viral genomes containing the mutagenized DNA and tested their transforming ability at 32 and 39 degrees C. We isolated three nontransforming mutants and two mutants which were cold sensitive for the maintenance of cell tra
-
11. Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen.
We used an oligonucleotide to introduce an A----T transversion at nucleotide position 1178 in polyoma virus DNA. The single effect of this mutation is to substitute phenylalanine for tyrosine at residue 315 of the middle-sized tumor (mT) protein (antigen). This site was previously identified as a major phosphate acceptor in the protein kinase reaction of imm
-
12. Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen.
Polyomavirus middle tumor antigen (MT) transforms a large number of cell types by binding to and modulating the activities of cellular proteins. Previous genetic analysis defined in MT an independent motif, NPTY (Asn-Pro-Thr-Tyr), required for transformation. This report demonstrates that NPTY is required for interaction between MT and SHC protein, a Src hom