Na Glucose Cotransporter
Mostrando 1-12 de 36 artigos, teses e dissertações.
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1. Use of sodium-glucose cotransporter-2 inhibitors and urinary tract infections in type 2 diabetes patients: a systematic review
RESUMO Os inibidores do cotransportador de sódio-glicose do tipo 2 (SGLT2i) são medicamentos que atuam mantendo a glicosúria. Estudos recentes têm demonstrado efeitos promissores desses no tratamento de diabetes mellitus tipo 2 (DM2). No entanto, pode haver um risco aumentado de desenvolver infecções do trato urinário (UTI) em pacientes tratados com e
Rev. Assoc. Med. Bras.. Publicado em: 2019-02
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2. Inhibition of the sodium-glucose co-transporter 2 in the elderly: clinical and mechanistic insights into safety and efficacy
RESUMO A prevalência da diabetes mellitus tipo 2 em idosos cresceu muito na última década. A redução na sensibilidade à insulina e na capacidade secretora, ganho de peso, sarcopenia e adiposidade elevada são todas alterações metabólicas e corporais comuns entre a população idosa. Essas mudanças críticas favorecem o aumento no risco de hipoglice
Rev. Assoc. Med. Bras.. Publicado em: 2019-01
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3. Central role of obesity in endothelial cell dysfunction and cardiovascular risk
RESUMO A aterosclerose é a causa líder de mortalidade no mundo contemporâneo. O papel central da célula endotelial (EC) na homeostase vascular, as alterações metabólicas que ocorrem quando a célula se torna ativada e os elementos envolvidos nesses processos vêm sendo bastante explorados nos últimos anos. A obesidade e o seu impacto, promovendo uma
Rev. Assoc. Med. Bras.. Publicado em: 2019-01
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4. A atividade simpática regula, via proteína cinase A (PKA), a proteína cotransportadora Na+/glicose 1 (SGLT1) em glândula salivar: efeitos do Diabetes Mellitus e da hipertensão arterial. / Na+/glucose cotransporter SGLT1 in the salivary glands of diabetic and hypertensive rats: role of sympathetic outflow and protein kinase A activity.
O objetivo do projeto foi estudar diferenças estruturais entre os anticorpos (Acs) IgG1 murinos anafiláticos e não-anafiláticos que possam determinar sua atividade biológica. Como resultado, foi identificada homologia de 100% da região Fc dos dois Acs IgG1. A análise da glicosilação destes Acs revelou maior conteúdo de ácido siálico e fucose na c
Publicado em: 2010
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5. Effect of glucose on pHi recovery in HEK-293 cells. / Efeito da glicose sobre recuperação do pHi em células HEK-293.
Os estudos foram realizados em cultura de células HEK-293 (human embrionic kidney cells). Por microscopia de fluorescência, avaliou-se a velocidade de recuperação do pHi (dpHi/dt). Por Western blot, avaliou-se a expressão de SGLTs e NHEs e a translocação dos SGLTs foi avaliada por imunofluorescência. Resultados: No controle, a dpHi/dt foi de 0,169 ±
Publicado em: 2009
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6. Influence of intake of grass mate (Ilex paraguariensis) on parameters related to diabetes mellitus and glucose metabolism in rats Wistar / Influência da ingestão de erva mate (Ilex paraguariensis) sobre parâmetros relacionados ao diabetes mellitus e metabolismo de glicose em ratos Wistar
Introduction: The incidence and prevalence of Diabetes Mellitus are increasing, reaching epidemic proportions. Yerba mate infusions are rich in polyphenols, especially chlorogenic acids, that are known to have antioxidant properties. Evidences suggest that dietary polyphenols could also play a role in glucose metabolism and absorption. Objective: The aim of
Publicado em: 2008
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7. Intestinal brush border membrane Na+/glucose cotransporter functions in situ as a homotetramer.
The functional unit molecular size of the intestinal brush border membrane-bound Na+/glucose cotransporter was determined by radiation inactivation. Purified brush border membrane vesicles preserved in cryoprotectant buffer were irradiated (-135 degrees C) with high-energy electrons from a 13-MeV (1 eV = 1.602 x 10(-19) J) linear accelerator at doses from 0
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8. The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose.
The major reabsorptive mechanism for D-glucose in the kidney is known to involve a low affinity high capacity Na+/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1, and which has a Na+ to glucose coupling ratio of 1:1. Here we provide the first molecular evidence for this renal D-glucose reabsorptive mechanism. We rep
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9. Expression of size-selected mRNA encoding the intestinal Na/glucose cotransporter in Xenopus laevis oocytes.
The expression of the rabbit intestinal brushborder Na/glucose cotransporter has been studied in Xenopus oocytes. Poly(A)+ RNA isolated from the intestinal mucosa was injected into oocytes, and the expression of the transporter in the oocyte plasma membrane was assayed by measuring the Na-dependent phlorizin-sensitive uptake of methyl alpha-D-[14C]glucopyran
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10. Cotransport of water by the Na+/glucose cotransporter
Water is transported across epithelial membranes in the absence of any hydrostatic or osmotic gradients. A prime example is the small intestine, where 10 liters of water are absorbed each day. Although water absorption is secondary to active solute transport, the coupling mechanism between solute and water flow is not understood. We have tested the hypo
The National Academy of Sciences of the USA.
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11. Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters.
Cotransport proteins are responsible for the active accumulation of organic substrates in cells. Na+ gradients provide the driving force for uptake of most substrates into eukaryotes and for a few substrates in some prokaryotes. We report here the cloning and sequencing of the human intestinal Na+/glucose cotransporter (SGLT1) and compare its structure with
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12. Ontogenic development of lamb intestinal sodium-glucose co-transporter is regulated by diet.
1. The ontogenic development of the intestinal Na(+)-glucose co-transporter was measured in lambs as a function of diet. Transport activity was assayed in brush-border membrane vesicles and the expression of transport protein in the brush-border membrane determined by Western analysis. 2. Na(+)-dependent D-glucose transport increased to a maximum (300-700 pm