Neonatal Rats
Mostrando 1-12 de 378 artigos, teses e dissertações.
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1. YAP activation promotes the transdifferentiation of cardiac fibroblasts to myofibroblasts in matrix remodeling of dilated cardiomyopathy
Yes-associated protein (YAP) is an important regulator of cellular proliferation and transdifferentiation. However, little is known about the mechanisms underlying myofibroblast transdifferentiation in dilated cardiomyopathy (DCM). We investigated the role of YAP in the pathological process of cardiac matrix remodeling. A classic model of DCM was established
Braz J Med Biol Res. Publicado em: 23/11/2018
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2. Ventilation-induced changes correlate to pulmonary vascular response and VEGF, VEGFR-1/2, and eNOS expression in the rat model of postnatal hypoxia
Neonatal asphyxia occurs due to reduction in oxygen supply to vital organs in the newborn. Rapid restoration of oxygen to the lungs after a long period of asphyxia can cause lung injury and decline of respiratory function, which result from the activity of molecules that induce vascular changes in the lung such as nitric oxide (NO) and vascular endothelial g
Braz J Med Biol Res. Publicado em: 08/10/2018
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3. Neonatal tobacco smoke reduces thermogenesis capacity in brown adipose tissue in adult rats
Maternal smoking is a risk factor for progeny obesity. We have previously shown, in a rat model of neonatal tobacco smoke exposure, a mild increase in food intake and a considerable increase in visceral adiposity in the adult offspring. Males also had secondary hyperthyroidism, while females had only higher T4. Since brown adipose tissue (BAT) hypofunction i
Braz J Med Biol Res. Publicado em: 19/04/2018
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4. Olfactory deficit as a result of clozapine withdrawal syndrome in an animal model of schizophrenia: preliminary results
ABSTRACT Clozapine is an antipsychotic that produces serious withdrawal effects in schizophrenic patients. Olfactory deficits are well known as part of negative symptoms, but it is not known whether antipsychotic use and/or withdrawal are implicated. Then, we tested clozapine withdrawal in association with two widely used schizophrenia models: Neonatal immun
An. Acad. Bras. Ciênc.. Publicado em: 2018-04
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5. Etanercept protects rat cardiomyocytes against hypertrophy by regulating inflammatory cytokines secretion and cell apoptosis
We aimed to investigate the effect of etanercept, a tumor necrosis factor-α (TNF-α) inhibitor, on rat cardiomyocyte hypertrophy and its underlying mechanism. Primary neonatal rat cardiomyocytes were isolated from Sprague-Dawley rats. The model of rat cardiomyocyte hypertrophy was induced by endothelin, and then treated with different concentrations of etan
Braz J Med Biol Res. Publicado em: 15/05/2017
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6. Effects of hyperbaric oxygen and nerve growth factor on the long-term neural behavior of neonatal rats with hypoxic ischemic brain damage
Abstract Purpose: To evaluate the effects of HBO (Hyperbaric oxygen) and NGF (Nerve growth factor) on the long-term neural behavior of neonatal rats with HIBD (Neonatal hypoxic ischemic brain damage). Methods: The HIBD model was produced by ligating the right common carotid artery of 7 days old SD (Sprague-Dawley) rats followed by 8% O2 + 92% N2 for 2h. To
Acta Cir. Bras.. Publicado em: 2017-04
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7. Neonatal necrotizing enterocolitis rat model attenuated by a remote ischemic preconditioning in the pregnant
Abstract Purpose: To evaluate the effect of remote ischemic preconditioning (r-IPC) administered to pregnant rats, in the ileum of newborn rats subjected to hypoxia and reoxygenation. Methods: We used three pregnant rats and their newborn rats distributed in three groups: 1) Control (C) - Newborn rats born from a pregnant rat which did not undergo any inte
Acta Cir. Bras.. Publicado em: 2017-03
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8. Brain caspase-3 and intestinal FABP responses in preterm and term rats submitted to birth asphyxia
Neonatal asphyxia can cause irreversible injury of multiple organs resulting in hypoxic-ischemic encephalopathy and necrotizing enterocolitis (NEC). This injury is dependent on time, severity, and gestational age, once the preterm babies need ventilator support. Our aim was to assess the different brain and intestinal effects of ischemia and reperfusion in n
Braz J Med Biol Res. Publicado em: 23/06/2016
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9. Antidiabetic Potential of Potentilla fulgens Roots in Validated Animal Models of Diabetes
The present study was undertaken to investigate the antidiabetic potential of tap roots of Potentilla fulgens in streptozotocin induced diabetic rat models. The crude powder, ethanolic, ethanolic: aqueous and aqueous extracts of tap roots were administered to normoglycemic- and streptozotocin (STZ)-induced diabetic rats in a single dose study. The ethanolic
Braz. arch. biol. technol.. Publicado em: 06/05/2016
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10. Effect of hyperbaric oxygenation on mitochondrial function of neuronal cells in the cortex of neonatal rats after hypoxic-ischemic brain damage
The timing and mechanisms of protection by hyperbaric oxygenation (HBO) in hypoxic-ischemic brain damage (HIBD) have only been partially elucidated. We monitored the effect of HBO on the mitochondrial function of neuronal cells in the cerebral cortex of neonatal rats after HIBD. Neonatal Sprague-Dawley rats (total of 360 of both genders) were randomly divide
Braz J Med Biol Res. Publicado em: 26/04/2016
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11. Testing electrode suitability for field stimulation of high-threshold biological preparations
IntroductionA problem posed by electrical field (E) stimulation of biological preparations with high excitation threshold is that the E intensity required for excitation is likely to induce water electrolysis at the electrode surface, which can alter the extracellular medium and cause deleterious effects on the cells. In this study, different electrode mater
Res. Biomed. Eng.. Publicado em: 2015-09
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12. Rat visceral yolk sac cells: viability and expression of cell markers during maternal diabetes
The function of the visceral yolk sac (VYS) is critical for embryo organogenesis until final fetal development in rats, and can be affected by conditions such as diabetes. In view of the importance of diabetes during pregnancy for maternal and neonatal health, the objective of this study was to assess fetal weight, VYS cell markers, and viability in female W
Braz J Med Biol Res. Publicado em: 10/07/2015