Neutralizing Antibody
Mostrando 1-12 de 1682 artigos, teses e dissertações.
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1. The use of neutralizing monoclonal antibody in patients with COVID-19: a systematic review and meta-analysis
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Bronchiolitis Hospitalization in Southern Brazil from 2002 to 2012: A Count Time-series Approach
Abstract INTRODUCTION: Because the antibody neutralizing respiratory syncytial virus (anti-RSV) has a short period of immunization and high cost, the identification of regions and months of highest occurrence of bronchiolitis is very important. METHODS: An Autoregressive Conditional Poisson model was constructed for count data and compared to the standard
Rev. Soc. Bras. Med. Trop.. Publicado em: 28/03/2019
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3. Advances and challenges in therapeutic monoclonal antibodies drug development
The use of serum containing polyclonal antibodies from animals immunized with toxins marked the beginning of the application of antibody-based therapy in late nineteenth century. Advances in basic research led to the development of the hybridoma technology in 1975. Eleven years later, the first therapeutic monoclonal antibody (mAb) was approved, and since th
Braz. J. Pharm. Sci.. Publicado em: 08/11/2018
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4. NF-kB mediated CX3CL1 activation in the dorsal root ganglion contributes to the maintenance of neuropathic pain induced in adult male Sprague Dawley rats
Abstract Purpose: To evaluate the role of CX3CL1 and NF-κB in the lumbar disc herniation induced neuropathic pain. Methods: After LDH induced by implantation of autologous nucleus pulposus (NP) on the left L5 nerve root was established, mechanical thresholds and thermal hyperalgesia were tested at relevant time points during an observation period of 28
Acta Cir. Bras.. Publicado em: 2018-07
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5. Cerebrospinal fluid-contacting nucleus mediates nociception via release of fractalkine
Increasing evidence suggests that the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) mediates the transduction and regulation of pain signals. However, the precise molecular mechanisms remain unclear. Studies show that release of fractalkine (FKN) from neurons plays a critical role in nerve injury-related pain. We tested the hypothesis that
Braz J Med Biol Res. Publicado em: 07/08/2017
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6. Antivenomics as a tool to improve the neutralizing capacity of the crotalic antivenom: a study with crotamine
Abstract Background Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. To achieve this goal, antivenom production must start from a suitable immunization protocol and proper venom mixtures. In Brazil, antivenom against South American rattlesnake (Crotalus durissus terrif
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/07/2017
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7. Preparation and neutralization efficacy of IgY antibodies raised against Deinagkistrodon acutus venom
Abstract Background The five-paced pit viper (Deinagkistrodon acutus), endemic to China and northern Vietnam, is responsible for most snakebites in the Chinese territory. Antivenom produced from horses is the main treatment for snakebites, but it may cause numerous clinical side effects and have other disadvantages involved in their production such as the
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 06/07/2017
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8. Can anti-bothropstoxin-I antibodies discriminate between Bothrops jararaca and Bothrops jararacussu venoms?
Abstract Background Snakes of the genus Bothrops, popularly known as pit vipers, are responsible for most cases of snakebite in Brazil. Within this genus, Bothrops jararacussu and B. jararaca deserve special attention due to the severity of their bites and for inhabiting densely populated areas. Regarding the treatment of snakebites by Bothrops jararacussu
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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9. Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults
ABSTRACT Introduction: The World Health Organization (WHO) recommends one single dose of the Yellow Fever (YF) vaccine based on studies of antibody persistency in healthy adults. We assessed the prevalence and titers of YF virus neutralizing antibodies in previously vaccinated persons aged ≥ 60 years, in comparison to younger adults. We also evaluated th
Rev. Inst. Med. trop. S. Paulo. Publicado em: 03/04/2017
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10. Anti-Trimeresurus albolabris venom IgY antibodies: preparation, purification and neutralization efficacy
Abstract Background Snakebite incidence in southwestern China is mainly attributed to one of the several venomous snakes found in the country, the white-lipped green pit viper Trimeresurus albolabris. Since antivenom produced from horses may cause numerous clinical side effects, the present study was conducted aiming to develop an alternative antivenom ant
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 22/09/2016
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11. A glycoprotein E gene-deleted bovine herpesvirus 1 as a candidate vaccine strain
A bovine herpesvirus 1 (BoHV-1) defective in glycoprotein E (gE) was constructed from a Brazilian genital BoHV-1 isolate, by replacing the full gE coding region with the green fluorescent protein (GFP) gene for selection. Upon co-transfection of MDBK cells with genomic viral DNA plus the GFP-bearing gE-deletion plasmid, three fluorescent recombinant clones w
Braz J Med Biol Res. Publicado em: 21/07/2015
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12. Rabies surveillance in bats in Northwestern State of São Paulo
Introduction Rabies is an important zoonosis that occurs in mammals, with bats acting as Lyssavirus reservoirs in urban, rural and natural areas. Rabies cases in bats have been recorded primarily in urban areas in Northwestern State of São Paulo
Rev. Soc. Bras. Med. Trop.. Publicado em: 2014-12