Neutrophil Elastase
Mostrando 1-12 de 181 artigos, teses e dissertações.
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1. Neutrophil elastase ameliorates matrix metalloproteinase-9 to promote lipopolysaccharide-induced acute lung injury in mice 1
ABSTRACT PURPOSE: To investigate the regulatory roles of neutrophil elastase (NE) and matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. METHODS: To construct LPS-induced ALI mouse models, wild-type C57BL/6 mice were administered 5.0 mg/kg of LPS through endotracheal, and/or 1.0 mg/kg of ONO-5046, and/
Acta Cir. Bras.. Publicado em: 2016-06
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2. Analysis of Interleukin 17A in periapical abscess and granuloma lesions
Abstract Interleukin 17A (IL-17A) is a proinflammatory cytokine responsible for the initiation and propagation of inflammation. One of its actions is the recruitment of neutrophils to the site of infection. The aim of this study was to investigate whether there is association between IL-17A expression and neutrophil infiltration in periapical abscesses and p
Braz. oral res.. Publicado em: 28/03/2016
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3. Fc?R e CR3 no lúpus eritematoso sistêmico: variantes polimórficas e sua influência na fagocitose e desgranulação dos neutrófilos / Fc?R and CR in systemic lupus erythematosus: polimorphisms and their influence in the phagocytosis and degranulation of neutrophils
Systemic lupus erythematosus (SLE) is an autoimmune disease in which disease-related and genetic factors and immunosuppressive and cytotoxic therapies all contribute to an increased susceptibility to infections. Factors predisposing to infection include defects in chemotaxis, abnormalities in neutrophil phagocytic activity, decreased immune complex (IC) and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2012
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4. Pb x laserterapia : mecanismos envolvidos na cicatrização de lesões cutâneas / PB x phototherapy : wound healing mechanisms of cutaneous lesions
Our group has been exploring the biological mechanisms underlying the inflammatory process of paracoccidioidomycotic lesions treated by HeNe laser on cutaneous lesions caused by the inoculation of yeast cells into the back foot-pad of Balb/c mice. In this work we showed that laser-treated mice presented reduction of footpad edema, greater histologic organiza
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/06/2012
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5. Avaliação das atividades anti-inflamatória, anticoagulante e antiproliferativa do inibidor de quimotripsina das sementes de erythrina velutina (EvCI)
Estudos indicam que vários componentes medicinais foram isolados de vegetais, os quais apresentam atividades antibacterianas, antifúngicas, antitumorais e anti-inflamatórias. Sepse é caracterizada por uma inflamação sistêmica que tem como conseqüência a produção exarcebada de mediadores inflamatórios, pela excessiva ativação de células inflama
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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6. Avaliação da capacidade leishmanicida de neutrófilos sobre a Leishmania (Leishmania) amazonensi in vitro e em um modelo de resistência in vivo / Evaluation of neutrophil leishmanicidal activity on Leishmania (Leishmania.) amazonensis in vitro and in a resistance model in vivo.
O enfoque do nosso trabalho foi estudar a participação de neutrófilos na infecção por Leishmania (Leishmania) amazonensis utilizando-se linhagens de camundongos suscetíveis (BALB/c) e resistentes (C3H/HePAs). Inicialmente, comparamos a evolução das lesões causadas pela L. (L.) amazonensis nas linhagens BALB/c e C3H/HePas, demonstrando-se que os camu
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/10/2010
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7. Novas propriedades do SKTI (Inibidor de tripsina de soja): inibição para elastase neutrofílica humana e efeitos no processo de injúria pulmonar aguda
Seeds from legumes including the Glycine max are known to be a rich source of protease inhibitors. The soybean Kunitz trypsin inhibitor (SKTI) has been well characterised and has been found to exhibit many biological activities. However its effects on inflammatory diseases have not been studied to date. In this study, SKTI was purified from a commercial soy
Publicado em: 2010
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8. Polymorphism of alpha-1-antitrypsin in hematological malignancies
Alpha-1-antitrypsin (AAT) or serine protease inhibitor A1 (SERPINA1) is an important serine protease inhibitor in humans. The main physiological role of AAT is to inhibit neutrophil elastase (NE) released from triggered neutrophils, with an additional lesser role in the defense against damage inflicted by other serine proteases, such as cathepsin G and prote
Genetics and Molecular Biology. Publicado em: 23/10/2009
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9. Estudo da modulação de funções efetoras de neutrófilos humanos por derivados cumarínicos: avaliação do efeito biológico sobre a produção de espécies reativas de oxigênio e a desgranulação / Study of modulation of human neutrophil effector functions by coumarin derivatives: evaluation of biological effect on reactive oxygen species production and degranulation
Neutrophils are phagocytic cells from the innate immune system with highly developed mechanisms for intracellular digestion of pathogens, immune complexes and cell debris, which are mainly mediated by reactive oxygen species (EROs) and proteolytic enzymes. However, massive neutrophil activation lead to release of large amounts of enzymes and EROs to the extr
Publicado em: 2009
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10. Interrelationship between serum and sputum inflammatory mediators in chronic obstructive pulmonary disease
Little is known about airway inflammatory markers in chronic obstructive pulmonary disease (COPD). The objective of the present study was to identify and try to correlate pulmonary and peripheral blood inflammatory markers in COPD. In a cross-sectional study on patients with stable COPD, induced sputum and blood samples were collected for the determination o
Brazilian Journal of Medical and Biological Research. Publicado em: 20/02/2008
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11. Caracterização, clonagem e expressão de um inibidor de elastase de neutrófilo humano, purificado de sementes de Caesalpinia echinata (paubrasil) / Characterization, cloning and expression of a human neutrophil elastase inhibitor, purified from Caesalpinia echinata (pau-brasil) seeds.
As proteases são enzimas que participam de diversos processos biológicos, como a liberação de peptídeos biologicamente ativos, a coagulação sangüínea, a fibrinólise e a cascata do complemento, mas também de processos patológicos, como a doença de Alzheimer, artrite e edema. Dentre essas enzimas, a elastase é uma das mais destrutivas do corpo, e
Publicado em: 2006
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12. Neutrophil Elastase Is Important for PML-Retinoic Acid Receptor α Activities in Early Myeloid Cells
Expression of the PML-retinoic acid receptor α (PML-RARα) fusion protein is the initiating genetic event for acute promyelocytic leukemia (APL), but the molecular mechanisms responsible for disease initiation are not yet clear. Several observations have suggested that early myeloid cells are uniquely susceptible to transformation by PML-RARα. Recently, we
American Society for Microbiology.