Nk 1 And Nk 3 Receptors
Mostrando 1-12 de 58 artigos, teses e dissertações.
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1. Envolvimento de receptores NK-1 e NK-3 no comportamento defensivo induzido pela estimulação elétrica da substância cinzenta periaquedutal dorsal / Involvement of NK-1 and NK-3 receptors on the defensive behavior induced by electrical stimulation of the dorsal periaqueductal gray.
A substância cinzenta periaquedutal dorsal (SCPd) é considerada uma das principais estruturas do teto mesencefálico envolvida no substrato neural da aversão a estímulos proximais. GABA e 5-HT são apontados como neurotransmissores envolvidos na modulação das respostas defensivas elaboradas na SCPd. Recentemente, mecanismos neurocininérgicos também t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/10/2011
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2. Identificação e quantificação da expressão de receptores toll-like 2, 4, e 9 na leishmaniose cutânea humana / Identification and quantification of the expression of toll-like receptors 2, 4 and 9 in the human cutaneous leishmaniasis
Introdução: Um dos primeiros sistemas de defesa contra os microrganismos é a via dos receptores Toll-like (TLRs). A ativação destes receptores leva à síntese de citocinas, dando início à resposta imune inata. Em modelos animais, o TLR2, TLR4 e TLR9 parecem estar relacionados com o reconhecimento de antígenos de Leishmania. A relação entre TLRs e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/05/2011
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3. Imunopatologia da dengue: receptores de quimiocinas CC e células iNKT
Dengue virus (DENV), a mosquito-borne flavivirus, is a serious public health problem in many tropical countries. Immune mechanisms involved in the pathogenesis of DENV infection are not fully elucidated. Recent clinical data showed an association between levels of different CC chemokines in plasma and severity of dengue. In this regard, we evaluated the role
Publicado em: 2010
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4. Analisys of polymorphism of KIR in patients with chronic C hepatitis. / Análise do polimorfismo do KIR em pacientes com hepatite crônica C submetidos à terapia antiviral.
The treatment of chronic hepatitis C is carried out using different types of alpha interferon associated to ribavirin. Factors such as viral genotype, viral load and characteristics of the host are important in the success of the therapy. Factors associated to the host such as immunologic and genetic may also have an important role in the treatment of hepati
Publicado em: 2007
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5. Involvement of the bradykinin B1 receptor and the paradoxical effect of the nitric oxide in the allergic lung inflammation in mice / Envolvimento do receptor B1 da bradicinina e o efeito paradoxal do oxido nitrico na inflamação alergica pulmonar em camundongos
A asma é uma doença inflamatória crônica que envolve, simultaneamente, a participação de diversos tipos celulares, citocinas e mediadores inflamatórios. Apesar do grande número de estudos sobre o papel da bradicinina e do óxido nítrico (NO) na asma, vários aspectos não foram abordados e outros são controversos. Os objetivos deste trabalho foram,
Publicado em: 2006
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6. Diazepam effects on tumor growth and on immunity of Ehrlich tumor bearing mice / Efeitos do diazepam sobre o crescimento tumoral e imunidade de animais portadores do tumor ascítico de Ehrlich
Benzodiazepines (BDZ) are drugs widely used due to their anxiolytic and sedative properties, acting on specific sites coupled to GABAA complex in the Central Nervous System (CNS). Besides these central receptors, BDZ have affinity for peripheral-type receptors (PBR), which have been found in immune cells, such as lymphocytes and macrophages, in tumor cells a
Publicado em: 2004
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7. Blockade of NK-1 receptors in the lateral commissural nucleus tractus solitarii of awake rats had no effect on the cardiovascular responses to chemoreflex activation
The neurotransmission of the chemoreflex in the nucleus tractus solitarii (NTS), particularly of the sympatho-excitatory component, is not completely understood. There is evidence that substance P may play a role in the neurotransmission of the chemoreflex in the NTS. Microinjection of substance P (50 pmol/50 nl, N = 12, and 5 nmol/50 nl, N = 8) into the com
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-11
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8. Distinct presynaptic control of dopamine release in striosomal- and matrix-enriched areas of the rat striatum by selective agonists of NK1, NK2, and NK3 tachykinin receptors.
Using a sensitive in vitro microperfusion method, the effects of selective and potent agonists of NK1, NK2, and NK3 tachykinin receptors ([Pro9]SP, ([Lys5,MeLeu9,Nle10]NKA-(4-10), and [Pro7]NKB, respectively) on the presynaptic control of dopamine release were investigated in striosomal-enriched (area rich in [3H]naloxone binding sites) and matrix-enriched a
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9. Heterologous regulation of trafficking and signaling of G protein-coupled receptors: β-Arrestin-dependent interactions between neurokinin receptors
Cells express multiple G protein-coupled receptors that are simultaneously or sequentially activated by agonists. The consequences of activating one receptor on signaling and trafficking of another receptor are unknown. We examined the effects of selective activation of the neurokinin 1 receptor (NK1R) on signaling and trafficking of the NK3R and vice versa.
The National Academy of Sciences.
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10. Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors.
The molecular mechanism of action for two chemically distinct and highly selective, nonpeptide antagonists, CP-96,345 and SR-48,968, was studied by development of a series of chimeric constructs between their respective target receptors, the NK1 (substance P) and NK2 (neurokinin A) receptors. The binding affinities of the natural peptide ligands, substance P
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11. Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation.
Substance P (SP) can cause plasma leakage at sites of inflammation by binding to neurokinin type 1 (NK1) receptors on the surface of endothelial cells. Internalization after ligand binding could reduce the number of NK1 receptors on the cell surface and thus participate in the desensitization and resensitization of the inflammatory response to SP. By using a
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12. Subset of natural killer cells is induced by immune complexes to display Fc receptors for IgE and IgA and demonstrates isotype regulatory function.
Expression of Fc receptors for IgE (FcER) or IgA (FcAR) on purified natural killer (NK) cells was investigated. No FcER+ and a few FcAR+ NK cells were detectable on freshly separated NK (NKH-1+) cells from normal donors. Incubation of NK cells with IgE-anti-IgE immune complexes or IgA-anti-IgA immune complexes induced up to 10 and 20% FcER+ or FcAR+ cells, r