Nmdar
Mostrando 1-12 de 70 artigos, teses e dissertações.
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1. Does mismatch negativity have utility for NMDA receptor drug development in depression?
Rapid antidepressant effects associated with ketamine have shifted the landscape for the development of therapeutics to treat major depressive disorder (MDD) from a monoaminergic to glutamatergic model. Treatment with ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, may be effective, but has many non-glutamatergic targets, and clinical and logis
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Prevalência plasmática de anticorpos IgG antirreceptor N-metil-d-aspartato nos estágios iniciais de psicose
Resumo Nós investigamos a viabilidade de incluir a pesquisa de anticorpos anti-NMDAR na avaliação de pacientes em primeiro episódio psicótico em um programa de intervenção precoce no Hemisfério Sul. Anticorpos IgG anti-NMDAR foram avaliados por ELISA em 166 pacientes (64,0% homens), 166 controles de base populacional pareados e 76 irmãos (30,3% home
Ciênc. saúde coletiva. Publicado em: 2021-03
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3. The poor insane Ophelia: reconsidering Ophelia syndrome
ABSTRACT The association between memory loss and Hodgkin's lymphoma has been given the eponym of Ophelia syndrome, in memory of Shakespeare's character in The Tragedy of Hamlet, Prince of Denmark. Nevertheless, there are differences between the disease and the character. Objective: To review the origins and uses of the eponym through an original article by
Arq. Neuro-Psiquiatr.. Publicado em: 05/12/2019
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4. Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress
The natural flavonoid glycoside baicalin (BA) produces a variety of pharmaceutical effects, particularly for psychiatric/neurological disorders. This study evaluated the behavioral and neuroprotective effects of BA in mice subjected to chronic unpredictable mild stress, a model of depression. BA (25 and 50 mg/kg) significantly increased sucrose consumption a
Braz J Med Biol Res. Publicado em: 19/06/2019
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5. Opistótono (arc de cercle) em um caso de encefalite anti-NMDAR
Arq. Neuro-Psiquiatr.. Publicado em: 2018-06
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6. Non-inflammatory cerebrospinal fluid delays the diagnosis and start of immunotherapy in anti-NMDAR encephalitis
ABSTRACT Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is a form of autoimmune encephalopathy that presents with a wide variety of symptoms, including neuropsychiatric manifestations. The authors’ aim for this study was to analyze the results of paraclinical studies of patients with a diagnosis of anti-NMDAR encephalitis and the association
Arq. Neuro-Psiquiatr.. Publicado em: 2018-01
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7. A Mechanism Study of NMDAR1 in A Rat Alzheimer Disease (AD) Model
ABSTRACT This study aimed to investigate the expression and mechanism of N- methyl -D- aspartate receptor 1 (NMDAR1) in the pathogenesis of Alzheimer disease (AD). Eighty adult Wistar rats were randomly divided into 4 groups (n=20 each) to receive an injection of 0, 5, 7 and 10 μl of 1 μg/μl amyloid-β 42 (Aβ1-42) in the hippocampus. Twenty rats in norma
Braz. arch. biol. technol.. Publicado em: 05/10/2017
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8. Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects
ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there
An. Acad. Bras. Ciênc.. Publicado em: 17/08/2017
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9. Ocorrência precoce de breves, rítmicas e potencialmente ictais descargas [B(I)RDS], e surgimento posterior de assimétrico extremo “delta brush” (EDB) num caso de encefalite Anti-NMDAr
Arq. Neuro-Psiquiatr.. Publicado em: 20/10/2015
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10. Manejo de sintomas comportamentais severos em um paciente com encefalite-anti-NMDAR: relato de caso e literatura atual
Objetivo: Sintomas psiquiátricos surgem em estágios precoces da encefalite antirreceptor N-metil-D-aspartato (NMDAR), o que faz muitos pacientes procurarem tratamento em serviços de psiquiatria antes de se dirigirem a unidades de clínica geral. Embora muitos artigos sobre encefalite anti-NMDAR venham sendo publicados na comunidade científica internacion
Trends Psychiatry Psychother.. Publicado em: 30/01/2015
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11. Cloning and sequencing of c-DNA encoding N-methyl-D-aspartate receptor subunit-1 in the hypothalamus of male sheep
The objective of the present study was to report the molecular cloning and determination of the sequences N-methyl-D-aspartate subunit-1 receptor (NMDAR-1) in the hypothalamus of sheep. The re-amplified DNA template for NMDA -1 from the hypothalamus of male sheep was cloned using pBluescript-Sk-plasmids (pBSK, 2958 bp). Purified plasmids containing the NMDA
R. Bras. Zootec.. Publicado em: 2014-04
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12. Efeitos de cetamina na formação da memória de longa duração e níveis de BDNF no hipocampo de ratos
A cetamina é uma droga dissociativa utilizada como anestésico humano. Este fármaco é também utilizado como droga de abuso por conter efeitos psicotrópicos. É sabido que a cetamina é um potente antagonista não competitivo do receptor glutamatérgico ionotrópico do tipo N metil-D-aspartato (NMDAr). A diminuição da neurotransmissão do glutamato pel
Publicado em: 2011