1. Regulation of dendritic cell survival and cytokine production by osteoprotegerin

The TNF family ligand, RANKL, and its two TNFR family receptors, RANK and OPG, enable coordinated regulation between the skeletal and immune systems. Relatively little is known about how OPG influences RANKL-RANK interactions for the regulation of DCs. Here, we show that OPG KO bone marrow-derived DCs survive better and produce more TNF-α, IL-12p40, and IL-

The Society for Leukocyte Biology.

2. osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation. In this study the physiological role of OPG is investigated by generating OPG-deficient mice. Adolescent and adult OPG−/− mice exhibit a decrease in total bone density characterized by severe trabecular and cortical bone porosity, marked thinning of the parietal bones of the

Cold Spring Harbor Laboratory Press.

3. Osmoregulated Periplasmic Glucan Synthesis Is Required for Erwinia chrysanthemi Pathogenicity

Erwinia chrysanthemi is a phytopathogenic enterobacterium causing soft rot disease in a wide range of plants. Osmoregulated periplasmic glucans (OPGs) are intrinsic components of the gram-negative bacterial envelope. We cloned the opgGH operon of E. chrysanthemi, encoding proteins involved in the glucose backbone synthesis of OPGs, by complementation of the

American Society for Microbiology.

4. Geographic Discrimination of Paracoccidioides brasiliensis Strains by Randomly Amplified Polymorphic DNA Analysis

Randomly amplified polymorphic DNA (RAPD) analysis of 33 Paracoccidioides brasiliensis strains from Argentina, Brazil, Colombia, Peru, and Venezuela produced reproducible amplification products which were sufficiently polymorphic to allow differentiation of the strains. Types generated with five primers (OPG 03, OPG 05, OPG 14, OPG 16, and OPG 18) resulted i

American Society for Microbiology.

5. DNA tagging of blast resistant gene(s) in three Brazilian rice cultivars

Rice blast is the most important fungal disease of rice and is caused by Pyricularia oryzae Sacc. (Telomorph Magnoporthe grisea Barr.). Seven randomly amplified polymorphic DNA (RAPD) markers OPA5, OPG17, OPG18, OPG19, OPF9, OPF17 and OPF19 showed very clear polymorphism in resistant cultivar lines which differed from susceptible lines. By comparing differen

Genetics and Molecular Biology. Publicado em: 2003-12

6. Expressão do receptor ativador de NF-kBETA (Rank), Rank ligante (RANKL), e Osteoproterina (OPG) em sítios de reparo ósseo de ratos diabéticos

To clarify the mechanisms of altered bone reapair in diabetic state, we investigate the RANK, RANKL and OPG expression by immunohistochemistry and RT-PCR in the fracture sites of diabetic rats. A closed fracture was performed on the anatomical left tibia in rats either healthy or made diabetic by alloxan. Histomorphometric analysis of fracture site at 7 days

Publicado em: 2007

7. Polimorfismos de nucleotídeo único dos genes do sistema OPG/RANKL em mulheres pré-menopausadas com lúpus: associação com massa óssea e fratura vertebral

Introdução: O aumento da sobrevida dos pacientes com lúpus eritematoso sistêmico (LES) foi acompanhado por um aumento da frequência de comorbidades, tais como osteoporose e fraturas. Há descrições de associação de polimorfismos dos genes receptor ativador do fator nuclear kappa B (RANK), seu ligante (RANKL) e da osteoprotegerina (OPG) com alteraç�

Biblioteca Digital de Teses e Dissertações da USP. Publicado em: 2014

8. Estudo da imunoexpressão de RANKL e OPG, do índice angiogênico (CD34) e da presença de miofibroblastos (α-SMA) em ceratocistos odontogênicos isolados e associados à síndrome de Gorlin / Estudo da imunoexpressão de RANKL e OPG, do índice angiogênico (CD34) e da presença de miofibroblastos (α-SMA) em ceratocistos odontogênicos isolados e associados à síndrome de Gorlin

Os ceratocistos odontogênicos se destacam em relação a outras lesões císticas odontogênicas pelo comportamento clínico potencialmente agressivo e por se apresentarem associados, em alguns casos, à síndrome de Gorlin. Estudos têm sugerido que os ceratocistos sindrômicos, em comparação às lesões isoladas, possuem maior capacidade de crescimento

Publicado em: 2010

9. Exprassão imuno-histoquímica dos fatores de reabsorção óssea em lesões centrais e periféricas de células gigantes

The Giant Cell Lesions, both the Central Giant Cells Lesions (CGCL) as the Peripheral Giant Cells Lesions (PGCL), correspond to a group of oral lesions that are histologically similar entities; however they show a variable clinical behaviour. The purpose of this study was to compare the immunohistochemical expression of bone resorption factors RANK (Receptor

Publicado em: 2010

10. Expressão imuno-hitoquímica das proteínas RANK, RANKL e OPG em cistos radiculares e cistos dentígeros

Receptor ativador nuclear κappa B (RANK), ligante do receptor ativador nuclear κappa B (RANKL) e osteoprotegerina (OPG) são membros da família do fator de necrose tumoral relacionados com o metabolismo ósseo. A formação, diferenciação e atividade dos osteoclastos são reguladas por estas três proteínas. RANK é um receptor transmembrana pr

Publicado em: 2010

11. Levels of Ligand receptor activator nuclear factor kb (RANKL) and Osteoprotegerin (OPG) in fluid peri-implant crevicular implants charged immediately in patients with osteopenia / Níveis do ligante receptor ativador do fator nuclear kb (Rankl) e osteoprotegerina (OPG) no fluido crevicular peri-implantar de implantes carregados imediatamente em pacientes com osteopenia

The successful outcome of immediately loaded implants is influenced by a number of confounding factors, such as bone remodeling response and bone quality in the periimplant site. Bone resorption is controlled by the interaction of the receptor activator of the NF-kß ligand (RANKL) and osteoprotegerin (OPG). RANKL induces osteoclast formation and activation

Publicado em: 2011

12. Effects of IL-10 and glucose on expression of OPG and RANKL in human periodontal ligament fibroblasts

The effects of interleukin-10 (IL-10) and glucose on mRNA and protein expression of osteoprotegerin (OPG), and its ligand, receptor activator of nuclear factor-κB ligand (RANKL), were investigated in human periodontal ligament fibroblasts (HPDLFs). Primary HPDLFs were treated with different concentrations of IL-10 (0, 1, 10, 25, 50, and 100 ng/mL) or glucos

Braz J Med Biol Res. Publicado em: 08/04/2016