Oral Chronic Toxicity
Mostrando 1-12 de 32 artigos, teses e dissertações.
-
1. Evaluation of the toxicity and hypoglycemic effect of the aqueous extracts of Cnidoscolus quercifolius Pohl
Diabetes mellitus is one of the most common chronic degenerative diseases, and it is estimated to increase worldwide to around 415 million and to impact 642 million in 2040. Research shows that some plants are sources of bioactive compounds against diabetes. Thus, the objective of this work was to evaluate the oral toxicity and the hypoglycemic effect of the
Braz J Med Biol Res. Publicado em: 31/08/2017
-
2. ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia
This study aimed to estimate the absorption, distribution, metabolism and excretion (ADME) properties and safety of LDT5, a lead compound for oral treatment of benign prostatic hyperplasia that has previously been characterized as a multi-target antagonist of α1A-, α1D-adrenoceptors and 5-HT1A receptors. The preclinical characterization of this compound co
Braz J Med Biol Res. Publicado em: 24/11/2016
-
3. A subchronic toxicity study of ethanol root extract of baked Aconitum flavum in rats
ABSTRACT The genus Aconitum has strong toxicity, but the acute toxicity of baked Aconitum flavum Hand.-Mazz., Ranunculaceae, was reduced significantly on the premise of keeping anti-inflammatory and anti-nociceptive activities. However, the risk associated with long-term use is unknown. In a sub-chronic toxicity study, rats were orally administered A. flavum
Rev. bras. farmacogn.. Publicado em: 2016-08
-
4. Protective effect of oryzanol isolated from crude rice bran oil in experimental model of diabetic neuropathy
Several studies have implicated the involvement of poor glycemic control and oxidative/nitrosative stress in the development of diabetic neuropathic pain, an important microvascular complication affecting more than 50% of diabetic patients. However, lack of understanding of the underlying etiology, development of tolerance, inadequate relief and possible tox
Rev. bras. farmacogn.. Publicado em: 06/09/2012
-
5. Chronic toxicologic study of the ethanolic extract of the aerial parts of Jatropha gossypiifolia in rats
This work presents the observed changes in Wistar rats under long treatment (thirteen weeks) with different oral doses of the ethanolic extract (EE) from Jatropha gossypiifolia L., Euphorbiaceae. The most significant toxic signs indicated a reduction of the activity in the central nervous system and digestive disturbances. The histopathological analysis show
Revista Brasileira de Farmacognosia. Publicado em: 2012
-
6. The toxicity evaluation of Syzygium cumini leaves in rodents
This study aimed to evaluate the safety of the hydroalcoholic extract (HE) of Syzygium cumini (L.) Skeels, Myrtaceae, leaves in rodents. Acute toxicity was evaluated through the determination of a LD50 in mice and rats (up to 14 days). In mice, the oral administration (p.o.) of the HE (0.1 at 6 g/kg) did not cause any death. When administered by intraperiton
Revista Brasileira de Farmacognosia. Publicado em: 30/09/2011
-
7. Atividade Anti-helmíntica e imunomoduladora de extratos de Cocos nucifera L. / Anthelmintic activity and immunomodulating extract of Cocos nucifera L.
The development of resistance to synthetic anthelmintic required the search for alternatives for control of gastrointestinal nematodes. Among these, there is the use of medicinal plants. The liquid from the bark of the green coconut (LBGC) was extracted from Cocos nucifera L, followed by obtaining the butanol extract from LBGC. The objectives of this study w
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 19/12/2008
-
8. Ensaios ToxicolÃgicos PrÃ-ClÃnicos com Extrato Bruto Seco das Folhas de Petiveria alliacea Linnà / Ensaios ToxicolÃgicos PrÃ-ClÃnicos com Extrato Bruto Seco das Folhas de Petiveria alliacea LinnÃ
The Petiveria alliacea LinnÃ, a popularly known as tipim, guinà and also, atipim; belongs to the family Phytolaccaceae and stands out for its pharmacological activity in infectology, rheumatology and oncology. This is one of the 10 plants most used in Afro-Brazilian cults in the city of Recife, Brazil. The purpose of this study was to evaluate the safety o
Publicado em: 2008
-
9. IMPACTO DA SUPLEMENTAÇÃO ALIMENTAR NA TOXICIDADE HEMATOLÓGICA E NA QUALIDADE DE VIDA DE MULHERES PORTADORAS DE CÂNCER DE MAMA SOB REGIME QUIMIOTERÁPICO ADJUVANTE
The chemotherapic adjuvant treatment is associated to neutropenia, complications of organic defense, alterations in the nutritional status, and negative impact on quality of life, which compromises the physical, emotional, and social aspects of cancer patients. Not controlled clinical trial, the type before and after, this work is a first attempt to analyze
Publicado em: 2008
-
10. AVALIAÇÃO DOS EFEITOS DO COMPLEXO QUITOSANA FERRO-III SOLÚVEL E INSOLÚVEL EM ANIMAIS TRATADOS COM ALOXANO / EVALUATION OF THE EFFECTS OF THE SOLUBLE AND INSOLUBLE IRON (III) -CHITOSAN COMPLEX IN ANIMALS TREATED WITH ALLOXAN
Chronic Kidney Disease consists of renal lesion and progressive, irreversible loss of glomerular, tubular and endocrine functions of the kidneys. Diseases like Diabetes mellitus and hypertension account for 79% of all cases of final stage renal disease requiring treatments like dialysis or transplant. In Chronic Renal Insufficiency (CRI), the absence of rena
Publicado em: 2007
-
11. Parameters of security and functionality of the Bifidobacterium isolated from newborn, with potential of use as probiotics in human milk banks / Parâmetros de segurança e funcionalidade de bactérias bífidas isoladas de recém-nascidos, com indicação de uso como probiótico em bancos de leite humano
The objective of this study was to evaluate some parameters of security and functionality currently recommended for validation of probiotics. The parameters evaluated were antimicrobial susceptibility, antagonism to the growth of pathogens, oral chronic toxicity and bacterial translocation of new lineages of Bifidobacterium breve isolated from newborn, with
Publicado em: 2006
-
12. AvaliaÃÃo toxicolÃgica prÃ-clÃnica do Ãleo de Carapa guianensis Aublet.
Carapa guianensis (Meliaceae), a typical tree from amazon region, is popularly known as Andiroba. Its seed oil is used as anti-inflammatory, analgesic and insect repellent. Although C. guianensis is largely used by people, there are no studies concerning its toxicity. In this way, the aim of this work was to evaluate the safety of the C. guianensis seed oil
Publicado em: 2006