Osteoclast
Mostrando 1-12 de 312 artigos, teses e dissertações.
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1. Leukotriene B4 Loaded in Microspheres Inhibits Osteoclast Differentiation and Activation
Resumo O objetivo deste trabalho foi Investigar a formação de osteoclastos in vivo e se o leucotrieno B4 (LTB4) incorporado em microesferas (MS) poderia ser usado como estratégia terapêutica para promover uma entrega sustentada do mediador e prevenir a diferenciação dos osteoclastos. Métodos: In vivo, a periodontite apical foi induzida em camundongos
Brazilian Dental Journal. Publicado em: 2022
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2. Impact of cigarette smoke on osteogenic and osteoclast signaling in middle palatal suture
Resumo Considerando que a fumaça de cigarro é um problema de saúde pública que está crescendo entre os adolescentes, o objetivo deste estudo foi investigar o impacto da fumaça de cigarro na sinalização osteogênica e osteoclastogênica da sutura palatina mediana de ratos. Foram utilizados ratos Wistar machos expostos (n=30) e não expostos à fumaça
Brazilian Dental Journal. Publicado em: 2022
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3. Consensus on diagnosis and management of non-metastatic castration resistant prostate cancer in Brazil: focus on patient, selection, treatment efficacy, side effects and physician's perception according to patient comorbidities
ABSTRACT Background: Non-metastatic castration resistant prostate cancer (M0 CRPC) has seen important developments in drugs and diagnostic tools in the last two years. New hormonal agents have demonstrated improvement in metastasis free survival in M0 CRPC patients and have been approved by regulatory agencies in Brazil. Additionally, newer and more sensiti
Int. braz j urol.. Publicado em: 2021-03
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4. The effect of graft application and simvastatin treatment on tibial bone defect in rats. A histological and immunohistochemical study
Abstract Purpose: To evaluate histologically and immunohistochemically the bone regeneration after application of simvastatin on tibial bone defects in rats. Methods: Sixty Wistar albino rats were divided into 3 groups as control (6 mm tibial bone defect), defect + graft (allograft treatment), and defect + graft + simvastatin (10 mg/kg/day) for 28 days.
Acta Cir. Bras.. Publicado em: 06/05/2019
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5. The effect of graft application and allopurinol treatment on calvarial bone defect in rats
Abstract Purpose: To investigate the effects of allopurinol administration on osteoinductive reaction and bone development with graft material. Methods: Thirty-six Wistar albino rats were divided into 3 groups. In the control group, calvarial bone defect was only created without any treatment. In the Defect + Graft group, allograft treatment was performed
Acta Cir. Bras.. Publicado em: 18/03/2019
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6. The effect of colchicine on alveolar bone loss in ligature-induced periodontitis
Abstract Colchicine is widely used in the treatment of several inflammatory diseases due to its anti-inflammatory effect, but effects on bone metabolism are unclear. The aim of this study was to evaluate the effects of systemically-administered colchicine on healthy periodontium and experimentally-induced periodontitis. In total, 42 male Wistar rats were inc
Braz. oral res.. Publicado em: 11/02/2019
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7. Effect of ProRoot MTA® and Biodentine® on osteoclastic differentiation and activity of mouse bone marrow macrophages
Abstract Objectives This investigation aimed to assess the differentiation inhibitory effects of ProRoot MTA® (PMTA) and Biodentine® (BIOD) on osteoclasts originated from murine bone marrow macrophages (BMMs) and compare these effects with those of alendronate (ALD). Materials and Methods Mouse BMMs were cultured to differentiate into osteoclasts with ma
J. Appl. Oral Sci.. Publicado em: 07/01/2019
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8. A novel effect of geraniin on OPG/RANKL signaling in osteoblasts
In this study, the effects of geraniin on osteoprotegerin/receptor activator of nuclear factor-κB ligand(OPG/RANKL) in regulating the proliferation of osteoblasts and suppression of osteoclast-like cells (OLC) in OLC-osteoblast co-cultured system in vitro were investigated. Osteoblasts were cultured and identified with alkaline phosphatase (ALP), gomori sta
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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9. Up-regulated expression of CD147 gene in malignant bone tumor and the possible induction mechanism during osteoclast formation
It is increasingly evident that the microenvironment of bone can influence cancer phenotype in many ways that favor growth in bone. CD147, a transmembrane protein of the immunoglobulin (Ig) superfamily, was identified independently in different species and has many designations across different species. However, expression levels of CD147 mRNA in bone cancer
Braz J Med Biol Res. Publicado em: 23/07/2018
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10. Effects of grape seed extract on periodontal disease: an experimental study in rats
Abstract Natural compounds capable of modulating the host response have received considerable attention, and herbal products are suggested as adjunctive agents in periodontal disease treatment. Objective This study aimed to demonstrate the effect of grape seed extract (GSE) on periodontitis. Material and Methods Ligature induced periodontitis was created
J. Appl. Oral Sci.. Publicado em: 2017-04
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11. Effects of alveolar bone displacement with segmental osteotomy: micro-CT and histomorphometric analysis in rats
Abstract The purpose of this study was to evaluate the effects of segmental osteotomy on the blood vessels and osteoclasts in rats using micro-computed tomography (micro-CT) and histomorphometric analysis. After segmental osteotomy was performed around the maxillary first molars of 36 male Sprague-Dawley rats (n = 72), the samples were divided into a control
Braz. oral res.. Publicado em: 28/11/2016
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12. Relationship between hypertension and periapical lesion: an in vitro and in vivo study
Abstract The aim of this study was to compare potential aspects of periapical lesion formation in hypertensive and normotensive conditions using hypertensive (BPH/2J) and wild-type control (BPN/3J) mice. The mandibular first molars of both strains had their dental pulp exposed. At day 21 the mice were euthanized and right mandibular molars were used to evalu
Braz. oral res.. Publicado em: 10/10/2016