Perinatal Toxicity
Mostrando 1-7 de 7 artigos, teses e dissertações.
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1. Estudo da toxicidade da Ipomoea carnea em ratas durante o período perinatal. Avaliação dos possíveis efeitos lesivos no tecido placentário / Ipomoea carnea toxicity study in rats during perinatal period. Evaluation of possible harmful effects on the placental tissue
A Ipomoea carnea é uma planta tóxica amplamente distribuída no Brasil e em outros países tropicais. Durante os períodos de seca esta planta se mantém verde, podendo servir como fonte de alimento para os animais de produção. A intoxicação natural é de caráter crônico e ocorre quando ruminantes particularmente, caprinos ingerem a planta, estes ani
Publicado em: 2009
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2. Avaliação da toxicidade da Ipomoea carnea em caprinos durante o período perinatal: estudos de neuroteratologia / Evaluation of the toxicity of Ipomoea carnea in goats during postnatal period
Ipomoea carnea, a shrub plant, is a toxic plant largely distributed throughout Brazil and others topical countries. This plant possess swainsonine, an indolizidinic alkaloid as the most important active toxic principle, which promotes cellular accumulation of not metabolized oligossacarides, due to inhibition of acid or lisossomal αmanosidasis enzyme,
Publicado em: 2009
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3. A model for prenatal toxicological studies in ruminants: evaluation of toxic effects caused by Senna occidentalis in goats / Proposta de modelo para o estudo de toxicologia perinatal em ruminantes: avaliação dos efeitos tóxicos da Senna occidentalis em caprinos
Senna occidentalis (So - formerly Cassia occidentalis), Fabaceae-Caesalpinoideae (Leguminosae) is a weed growing in pastures and in cultivated fields such as corn and soybeans in many tropical and subtropical areas worldwide. Many reports have shown that So is toxic to different animal species. Histologic lesions plant-related are degeneration skeltal and ca
Publicado em: 2008
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4. Parâmetros inflamatórios, imunológicos e histopatológicos da administração prolongada da Ipomoea carnea em ratos: 1. Avaliação em animais adultos 2. Estudo perinatal / Inflammatory, immunological and histopathological parameters of prolonged administration of Ipomoea carnea in rats: 1. Evaluation of adult animals 2. Perinatal study
The aim of this study was to evaluate the toxic effect of I. Carnea and its toxins on the immune system of rats, and to evaluate its effects on mothers and offspring when administered to dams during gestation or lactation. An alkaloid-rich plant extract (RAF) was added to drinking water to obtain doses equivalent to 3.0 and 15.0g/kg of dry leaves for 14 and
Publicado em: 2006
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5. Toxicity of cyanide in swine: evaluation of perinatal effects / Toxicidade do cianeto em suínos. Avaliação dos efeitos perinatais
Cyanide and cyanogenic compounds are ubiquitous in nature and widely studied in toxicology. Long-term cyanide exposure has been associated to development of goiter, pancreatic diabetes, and several neurological diseases in humans and animals. However, the exact mechanism involved in induction of these diseases are not fully elucidated. It is believed that th
Publicado em: 2006
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6. Efeitos da exposição gestacional a fração aquosa da Ipomoea carnea no desenvolvimento físico e neurocomportamental da prole de ratos. / Ipomoea carnea aqueous fraction intake effects during gestation on physical and neurobehavior development of rats offspring.
Ipomoea carnea, plant Iargely distributed in Brazil, when ingested by animais causes neurotoxic effects. No relates about its effects upon offspring of animais exposed during gestation period appears in the literature. So, in this work, the effects of the exposure of rats, during the gestation period, to the plant were studied. The rats received, by gavage,
Publicado em: 2002
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7. Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes
In cultured oligodendrocytes isolated from perinatal rat optic nerves, we have analyzed the expression of ionotropic glutamate receptor subunits as well as the effect of the activation of these receptors on oligodendrocyte viability. Reverse transcription–PCR, in combination with immunocytochemistry, demonstrated that most oligodendrocytes differentiated i
The National Academy of Sciences of the USA.