Peroxiredoxins
Mostrando 1-12 de 20 artigos, teses e dissertações.
-
1. Peroxiredoxin isoforms are associated with cardiovascular risk factors in type 2 diabetes mellitus
The production of oxygen free radicals in type 2 diabetes mellitus contributes to the development of complications, especially the cardiovascular-related ones. Peroxiredoxins (PRDXs) are antioxidant enzymes that combat oxidative stress. The aim of this study was to investigate the associations between the levels of PRDX isoforms (1, 2, 4, and 6) and cardiova
Braz J Med Biol Res. Publicado em: 03/03/2015
-
2. Expression of oxidative stress and antioxidant defense genes in the kidney of inbred mice after intestinal ischemia and reperfusion
PURPOSE: To determine the gene expressions profile related to the oxidative stress and the antioxidant response in the kidneys of mice subjected to intestinal ischemia and reperfusion. METHODS: Twelve inbred mice (C57BL/6) were randomly assigned to one of two groups: the control group (CG) underwent anesthesia and was observed for 120 min and the ischemia/re
Acta Cir. Bras.. Publicado em: 2013-12
-
3. Caracterização de nanopartículas contendo insulina em modelos de animais induzidos ao diabetes / Characterization of nanoparticles containing insulin in animal models induced diabetes
Diabetes Mellitus is a disease whose cases have increased due to the bad habits of life of society. Several strategies have been developed for the treatment of diabetes, especially the controlled release of drugs. The erroneous use of insulin as basal treatment of diabetes takes a problem, since the high dose of the drug can lead to severe hypoglycemia. The
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 05/08/2010
-
4. Interações de peroxirredoxinas citossólicas da levedura Saccharomyces cerevisiae com peróxidos. Estudos cinéticos e funcionais / Saccharomyces cerevisiae cytosolic peroxiredoxin interactions with peroxides. Kinetics and functional studies
Peroxiredoxins constitute a family of cysteine-based peroxidases that are able to reduce hydrogen peroxide, organic peroxides and peroxinitrite to water, alcohol and nitrite, respectively, through the use of reducing equivalents provided by thioredoxin, thioredoxin reductase and NADPH. Peroxiredoxins are abundant enzymes (correspond to approximately 0.7% of
Publicado em: 2009
-
5. Ahp1 e Tsa1 de Saccharomyces cerevisiae: regulação gênica, caracterização bioquímica, estrutura e função das duas peroxirredoxinas mais abundantes de leveduras / Saccharomyces cerevisiae Ahp1 and Tsa1: transcriptional regulation, biochemical characterization, structure and function of the two most abundant peroxiredoxins from yeast.
The incomplete reduction of oxygen to water during respiration results in the formation of Reactive Oxygen Species (ROS), oxidizing compounds, which can generate severe cellular oxidative stress. Aerobic cells are equipped with a complex defense system to cope with this condition. Peroxiredoxins make up a family of antioxidant enzymes with the ability to rem
Publicado em: 2007
-
6. Estudo da função de tiorredoxina peroxidase citoplasmatica I em Saccharomyces cerevisiae
Cytosolic thioredoxin peroxidase I (cTPxI) is a Saccharomyces cerevisiae antioxidant enzyme that belongs to peroxiredoxins family, conserved from bacteria to humans, able to reduce hydroperoxides in the presence of a thiol substrate. Our study concerning its role in yeast cells demonstrated that CTPXI is highly expressed in cells exposed to different H2O2 co
Publicado em: 2002
-
7. Proteomic detection of hydrogen peroxide-sensitive thiol proteins in Jurkat cells
Thiol proteins are important in cellular antioxidant defenses and redox signalling. It is postulated that reactive oxidants cause selective thiol oxidation, but relative sensitivities of different cell proteins and critical targets are not well characterized. We exposed Jurkat cells to H2O2 for 10 min and measured changes in reversibly oxidized proteins by
Portland Press Ltd..
-
8. Structural and functional characterization of the Pseudomonas hydroperoxide resistance protein Ohr
Bacteria have developed complex strategies to detoxify and repair damage caused by reactive oxygen species. These compounds, produced during bacterial aerobic respiration as well as by the host immune system cells as a defense mechanism against the pathogenic microorganisms, have the ability to damage nucleic acids, proteins and phospholipid membranes. Here
Oxford University Press.
-
9. Resemblance and Dissemblance of Arabidopsis Type II Peroxiredoxins: Similar Sequences for Divergent Gene Expression, Protein Localization, and Activity1
The Arabidopsis type II peroxiredoxin (PRXII) family is composed of six different genes, five of which are expressed. On the basis of the nucleotide and protein sequences, we were able to define three subgroups among the PRXII family. The first subgroup is composed of AtPRXII-B, -C, and -D, which are highly similar and localized in the cytosol. AtPRXII-B
The American Society for Plant Biologists.
-
10. Protective Function of Chloroplast 2-Cysteine Peroxiredoxin in Photosynthesis. Evidence from Transgenic Arabidopsis1
2-Cysteine peroxiredoxins (2-CPs) constitute a ubiquitous group of peroxidases that reduce cell-toxic alkyl hydroperoxides to their corresponding alcohols. Recently, we cloned 2-CP cDNAs from plants and characterized them as chloroplast proteins. To elucidate the physiological function of the 2-CP in plant metabolism, we generated antisense mutants in A
American Society of Plant Physiologists.
-
11. Central Functions of the Lumenal and Peripheral Thylakoid Proteome of Arabidopsis Determined by Experimentation and Genome-Wide Prediction
Experimental proteome analysis was combined with a genome-wide prediction screen to characterize the protein content of the thylakoid lumen of Arabidopsis chloroplasts. Soluble thylakoid proteins were separated by two-dimensional electrophoresis and identified by mass spectrometry. The identities of 81 proteins were established, and N termini were sequenced
American Society of Plant Biologists.
-
12. Poplar Peroxiredoxin Q. A Thioredoxin-Linked Chloroplast Antioxidant Functional in Pathogen Defense1
Peroxiredoxins are ubiquitous thioredoxin- or glutaredoxin-dependent peroxidases, the function of which is to destroy peroxides. Peroxiredoxin Q, one of the four plant subtypes, is a homolog of the bacterial bacterioferritin comigratory proteins. We show here that the poplar (Populus tremula x Populus tremuloides) protein acts as a monomer with an intramolec
The American Society for Plant Biologists.