Pharmacokinetics Properties
Mostrando 1-12 de 58 artigos, teses e dissertações.
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1. Probing the Pharmacological Parameters, Molecular Docking and Quantum Computations of Plant Derived Compounds Exhibiting Strong Inhibitory Potential Against NS5 from Zika Virus
ABSTRACT Zika virus (ZIKV) is known for microcephaly and neurological disease in humans and the nonstructural proteins of ZIKV play a fundamental role in the viral replication. Among the seven nonstructural proteins, NS5 is the most conserved and largest protein. Two major functional domains of NS5 i.e. methyltransferase (MTase) and RNA-dependent RNA polymer
Braz. arch. biol. technol.. Publicado em: 29/11/2018
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2. Pre-clinical interaction of ayahuasca, a brew used in spiritual movements, with morphine and propofol
ABSTRACT Ayahuasca is a beverage with psychoactive properties used in religious and ceremonial rituals by some religious groups. The main active components of ayahuasca are dimethyltryptamine and the harmala alkaloids with β-carboline structure acting as monoamine oxidase A inhibitors. This combination produces a pronounced activation of serotonergic pathwa
Braz. J. Pharm. Sci.. Publicado em: 07/06/2018
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3. Mass Spectrometry Analysis of Protonated Marine Natural Product Seriniquinone
Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in elec
J. Braz. Chem. Soc.. Publicado em: 2018-05
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4. Effect of superfine pulverization on physicochemical and medicinal properties of Qili Powder
Qili Powder, a preparation from Traditional Chinese Medicine, commonly used to treat injuries from falling or stumbling, pain caused by bruising, and traumatic hemorrhage. The aim of the present work was to investigate the application of the superfine pulverization on Qili Powder properties. The physicochemical and medicinal properties of fine Qili Powder wi
Rev. bras. farmacogn.. Publicado em: 2014-10
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5. Efeitos dos anestesicos locais na transmissão neuromuscular e no bloqueio produzido pelo rocuronio : estudo experimental / The effects of local anesthetics on the neuromuscular transmission and on the blockade produced by rocuronium : experimental study
Local anesthetics can interact with neuromuscular blockers and modify their pharmacokinetics and pharmacodynamics properties but this mechanism of interaction is very controversial. This experimental study performed in rat phrenic nerve diaphragm preparation and chick biventer cervicis muscle, had the objective to evaluate the effect of different local anest
Publicado em: 2009
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6. In Silico Models Development of ADME Properties to Screening New Chemical Entities / Desenvolvimento de modelos in silico de propriedades de ADME para a triagem de novos candidatos a fármacos
As ferramentas de modelagem molecular e de estudos das relações quantitativas entre a estrutura e atividade (QSAR) ou estrutura e propriedade (QSPR) estão integradas ao processo de planejamento de fármacos, sendo de extremo valor na busca por novas moléculas bioativas com propriedades farmacocinéticas e farmacodinâmicas otimizadas. O trabalho em Quím
Publicado em: 2007
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7. Proposta de utilização do vitrocerâmico anortita como um sistema de liberação de fármacos
Anortita glass-ceramic is a biocompatible material that shows intelligent material properties, since its degradation occurs depending on pH variation. This characteristic is particularly interesting when regarding clinical applications in which the material should start degradation when in contact with biological fluids, like in temporary implants. The use o
Publicado em: 2007
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8. Analysis of pharmacokinetics and PK/PD indices of doxycycline in plasma, gingival crevicular fluid and saliva and evaluation of its effect on the osteoclastogenesis RANKL-mediated / Analise da farmacocinetica e dos indices PK/PD da doxiciclina no plasma, fluido gengival e saliva e avaliação de seu efeito sobre a osteoclastogenese mediada por RANKL
Doxycycline (Dox), a member of the tetracycline family, is an antimicrobial agent with a broad-spectrum of activity against Gram-positive and Gram-negative bacteria. In addition to its antimicrobial properties, Dox is used in the treatment of periodontal diseases as a host response modulator by inhibiting the activity of an important enzyme, matrix metallopr
Publicado em: 2007
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9. Influencia da evolução do tecido granulomatoso sobre a biodisponibilidade da amoxicilina : estudo ex vivo, em ratos
Since the penicillin was discovered many studies have been carried out in order to justify its large use, however in some aspects about pharmacokinetics properties have not yet well understood. The subject of this study was to evaluate the penetration of amoxicillin in chronic lesion, as well as in serum levels. We used 160 rats with four PVC sponges previou
Publicado em: 1996
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10. Pharmacokinetics of cephalosporins in normal and septicemic rabbits.
The differences in the pharmacokinetics of cefotaxime, moxalactam, and CPW 86-363, a new expanded-spectrum cephalosporin, were studied in healthy rabbits and in rabbits infected intravenously with Streptococcus pneumoniae. The pharmacokinetic analysis of concentration-time courses in the sera of infected animals according to a two compartment-model evidenced
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11. Charge and lipophilicity govern the pharmacokinetics of glycopeptide antibiotics.
The pharmacokinetics and urinary excretion of nine glycopeptide antibiotics with diverse pIs (3.8 to 8.5) and lipophilicities were studied. The disposition of the aridicin antibiotics and their hydrolysis products were examined in male CD-1 mice after subcutaneous and intravenous administration and compared with the disposition of teicoplanin, ristocetin, an
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12. Comparative pharmacokinetics of clarithromycin (TE-031), a new macrolide antibiotic, and erythromycin in rats.
Clarithromycin (TE-031) is a newly synthesized macrolide with high stability in acidic conditions. In the present study, the pharmacokinetics of [N-methyl-14C]clarithromycin were compared with those of [N-methyl-14C]erythromycin in rats by radioassay and bioassay. Both radioactivity and bioactivity of [14C]clarithromycin in plasma and tissues were found to b