Phenothiazine
Mostrando 1-12 de 59 artigos, teses e dissertações.
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1. Activated Complex Approach to Describe Bovine Serum Albumin-Azure A and Bovine Serum Albumin-Azure B Intermolecular Interactions
Azure A (AZA) and azure B (AZB) phenothiazine dyes are used for clinical and medical purposes, and their functions can be altered via interactions with proteins. However, no kinetics information on the interactions between phenothiazine dyes and bovine serum albumin (BSA) is available. Surface plasmon resonance was used to determine the energetic and dynamic
J. Braz. Chem. Soc.. Publicado em: 2020-12
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2. New Insights into the Partitioning of Phenothiazine Dyes in Aqueous Two-Phase Systems
Aqueous two-phase systems (ATPSs) have proven to be efficient and environmentally safe methods for extracting chemical species. However, the driving forces behind the partition of solutes in these systems are still little understood. A complete thermodynamic partitioning of phenothiazine dyes was investigated in poly(ethylene oxide) (PEO) + salt + water ATPS
J. Braz. Chem. Soc.. Publicado em: 2020-08
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3. Comparison of apical periodontitis repair in endodontic treatment with calcium hydroxide-dressing and aPDT
Abstract This study evaluated the effect of antimicrobial photodynamic therapy (aPDT) on the endodontic treatment of apical periodontitis (AP). AP was induced in 48 premolars of 6 dogs. After biomechanical preparation, the teeth were divided into 4 groups: Calcium-Hydroxide (CH)/120d and CH/180d: root canals filled with CH-based dressing for 15 days before o
Braz. oral res.. Publicado em: 26/09/2019
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4. Tricyclic Cationic Chromophores as Models for New Photoantimicrobials
Despite the preponderance of literature pertaining to photosensitisers based on the porphyrin system, many other chemical classes are available with similar or improved characteristics and potential for use in photodynamic medicine. Several of these classes are based on small, tricyclic, heteroaromatic chromophores, often originally developed from textile dy
J. Braz. Chem. Soc.. Publicado em: 2015-12
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5. FOTODEGRADATION OF PHENOTHIAZINES AND THEIR STRUCTURAL EFFECTS ON NA(+)K(+) - ATPASE: A FLUORESCENCE STUDY / FOTODEGRADAÇÃO DE FENOTIAZINAS E SEUS EFEITOS ESTRUTURAIS SOBRE A NA(+), K(+) - ATPASE: ESTUDO ATRAVÉS DE FLUORESCÊNCIA
Chlorpromazine (CPZ), fluphenazine (FPZ) and trifluoperazine (TFP) are phenothiazine derivatives, which generate photoproducts under UV irradiation. We observed that CPZ develops three fluorescent fotoproducts under different conditions. Promazine (PZ) that forms from the CPZ photolysis. The chlorine loss is one of the main pathways for photoproduct formatio
Publicado em: 2010
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6. Synthesis and study of photoinduced properties of phenothiazine derivatives on biomimetic systems / Síntese e estudo das propriedades fotoinduzidas de derivados fenotiazínicos em sistemas biomiméticos
The effect of interfaces on photophysical and photochemical properties of methylene blue (MB) and its derivatives was studied in this work, aiming to emploit their potencial as photosensitizers (PS) in photodynamic therapy.The presence of MB in SDS solutions affect the micelle equilibrium decreasing the apparent critical micelle concentration of SDS from 7mm
Publicado em: 2008
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7. Reduction of molecular oxygen in aqueous solutions through modifying electrodesmethodology / Redução de oxigênio molecular em soluções aquosas através da metodologia de modificação de eletrodos
This work consisted in testing the viability of investigations into the electrochemical generation and identification of free radicals involved in advanced oxidative processes. In these studies, a technique which is rarely used for the electrochemical generation and identification of free radicals at organothiole-modified electrodes, electrochemical impedanc
Publicado em: 2007
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8. In vitro chloroquine resistance modulation study on fresh isolates of Brazilian Plasmodium falciparum: intrinsic antimalarial activity of phenothiazine drugs
Phenothiazine drugs - fluphenazine, chlorpromazine, methotrimeprazine and trifluoperazine - were evaluated as modulating agents against Brazilian chloroquine-resistant fresh isolates of Plasmodium falciparum. Aiming to simulate therapeutic schedules, chloroquine was employed at the concentration used for sensitive falciparum malaria treatment and anti-psycho
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-10
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9. Estudo eletroquimico de corantes organicos com propriedades redox imobilizados sobre o fosfato de zirconio
Methylene Blue (MB) and Nile Blue (NB), a phenothiazine and a phenoxazine dyes respectively, were adsorbed on zirconium (IV) phosphate (ZP) by ion exchange reaction. The dyes were strongly retained and were not leached out from the matrix. The materials with adsorbed dyes (ZPMB e ZPNB) were incorporated into a carbon paste electrode and the electrochemical p
Publicado em: 1997
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10. Calcium-dependent interaction of S100b, troponin C, and calmodulin with an immobilized phenothiazine.
We have purified the brain-specific protein S100b by affinity-based adsorption chromatography on phenothiazine-Sepharose conjugates and studied the interaction of this and other calcium-modulated proteins with the immobilized antipsychotic drug. Bovine brain calmodulin, rabbit skeletal muscle troponin C, and bovine brain S100b bind to phenothiazine-Sepharose
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11. Chlorpromazie and Dopamine: Conformational Similarities that Correlate with the Antischizophrenic Activity of Phenothiazine Drugs
Phenothiazines and butyrophenones are known to alter dopamine (3,4-dihydroxyphenethylamine) metabolism in the brain in a fashion suggesting that they may block dopamine receptors. We observed, using Dreiding molecular models, that dopamine in its solid-state conformation is superimposable upon a portion of the known x-ray structure of chlorpromazine [2-chlor
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12. Phenothiazine compounds inhibit in vitro growth of pathogenic free-living amoebae.
The phenothiazine compounds trifluoperazine dihydrochloride and chlorpromazine hydrochloride have in vitro activity against the pathogenic free-living amoebae Naegleria fowleri, Acanthamoeba culbertsoni, and Acanthamoeba polyphaga. Drug concentrations of 10 microM were amoebastatic; concentrations of 50 microM were either amoebastatic or amoebicidal. Concent