Plasminogen Activator Inhibitor 1
Mostrando 1-12 de 230 artigos, teses e dissertações.
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1. Bone Marrow Mesenchymal Stem Cells Regulate Coagulation and Inflammation Together in Methotrexate Induced Lung Injury Rat Model
Abstract Clinical research has shed the light on the relation between coagulation and inflammation. Coagulation cascade is activated in lung injury resulting in thrombotic and fibrotic lesions. Such a cascade is initiated by inflammation, then the two systems intense each other. New therapies that modulate coagulation and inflammation will be more successfu
Braz. arch. biol. technol.. Publicado em: 25/11/2019
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2. Platelet function, coagulation and fibrinolysis in patients with previous coronary and cerebrovascular ischemic events
OBJECTIVES: Ischemic stroke (IS) or transient ischemic attack (TIA) history is present in 4-17% of patients with coronary artery disease (CAD). This subgroup of patients is at high risk for both ischemic and bleeding events. The aim of this study was to determine the role of platelet aggregability, coagulation and endogenous fibrinolysis in patients with CA
Clinics. Publicado em: 26/09/2019
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3. Evaluation of Serum Levels of Inflammation, Fibrinolysis and Oxidative Stress Markers in Coronary Artery Disease Prediction: A Cross-Sectional Study
Resumo Fundamento: A doença arterial coronariana (DAC) tem sido há muito reconhecida como um problema de saúde global. Inflamação, fibrinólise e estresse oxidativo desempenham um papel importante no acometimento das placas, levando à DAC. Os marcadores que refletem esse mecanismo fisiopatológico podem ter valor prognóstico. Objetivo: Estimar as co
Arq. Bras. Cardiol.. Publicado em: 29/08/2019
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4. The impact of metabolic syndrome on metabolic, pro-inflammatory and prothrombotic markers according to the presence of high blood pressure criterion
OBJECTIVES: We explored whether high blood pressure is associated with metabolic, inflammatory and prothrombotic dysregulation in patients with metabolic syndrome. METHODS: We evaluated 135 consecutive overweight/obese patients. From this group, we selected 75 patients who were not under the regular use of medications for metabolic syndrome as defined by
Clinics. Publicado em: 2013-12
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5. Morphometric evaluation of nitric oxide synthase isoforms and their cytokine regulators predict pulmonary dysfunction and survival in systemic sclerosis
Because histopathological changes in the lungs of patients with systemic sclerosis (SSc) are consistent with alveolar and vessel cell damage, we presume that this interaction can be characterized by analyzing the expression of proteins regulating nitric oxide (NO) and plasminogen activator inhibitor-1 (PAI-1) synthesis. To validate the importance of alveolar
Braz J Med Biol Res. Publicado em: 2013-10
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6. Marcadores do sistema hemostático e sua associação com parâmetros clínicos e laboratoriais em mulheres com síndrome dos ovários policísticos = : Markers of the hemostatic system and their association with clinical and laboratory parameters in women with polycystic ovary syndrome / Markers of the hemostatic system and their association with clinical and laboratory parameters in women with polycystic ovary syndrome
Introduction: Few studies have been conducted on hemostatic disorders in polycystic ovary syndrome (PCOS). In women with PCOS, thromboembolic risk factors such as obesity, hyperandrogenism and insulin resistance are often present, indirectly suggesting a greater probability of coagulation disorders. Objective: To evaluate some markers of the hemostatic syste
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/10/2012
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7. Relationship between plasminogen activator inhibitor type-1 (PAI-1) gene polymorphisms and osteoporosis in Turkish women
OBJECTIVE: The development of osteoporosis is associated with several risk factors, such as genetic structures that affect bone turnover and bone mass. The impact of genetic structures on osteoporosis is not known. Plasminogen activator inhibitor type-1 regulates the bone matrix and bone balance. This study assessed the correlation between plasminogen activa
Clinics. Publicado em: 2012-11
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8. Efeito da ração hiperlipídica e do extrato aquoso de erva-mate (Ilex paraguariensis) sobre a composição corporal e sobre a resposta inflamatória de macrófagos peritoniais de ratos Wistar / Effect of high-fat diet and yerba mate aqueous extract (Ilex paraguariensis) on body composition and on inflammatory response of peritonial macrophages in Wistar rats
Introduction Inflammation is involved in the pathogenesis of metabolic syndrome and non communicable chronic diseases (NCCD). In macrophages, the nuclear transcription factor kappa B (NF-B) controls the gene expression of many inflammatory mediators and its activity can be regulated by several food bioactive compounds. Yerba mate (Ilex paraguariensis) contai
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/09/2011
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9. Plasma von Willebrand factor as a predictor of survival in pulmonary arterial hypertension associated with congenital heart disease
Biomarkers have been identified for pulmonary arterial hypertension, but are less well defined for specific etiologies such as congenital heart disease-associated pulmonary arterial hypertension (CHDPAH). We measured plasma levels of eight microvascular dysfunction markers in CHDPAH, and tested for associations with survival. A cohort of 46 inoperable CHDPAH
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-12
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10. Adipocitocinas na síndrome antifosfolípide primária: potenciais marcadores de inflamação, resistência insulínica e síndrome metabólica / Adipocytokines in primary antiphospholipid syndrome: potential markers of inflammation, insulin resistance and metabolic syndrome
INTRODUCTION: Antiphospholipid syndrome is associated with accelerated atherosclerosis. Although adipocytokines play a key role in the interface between obesity, inflammation, insulin resistance and atherosclerosis, the exact nature and relative contribution of adipocytokines as potential markers warrant further investigation in primary antiphospholipid synd
Publicado em: 2011
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11. Hemostatic changes and clinical sequelae after on-pump compared with off-pump coronary artery bypass surgery: a prospective randomized study / Alterações hemostáticas e clínicas em cirurgias de revascularização miocárdica com e sem circulação extracorpórea: estudo prospectivo randomizado
Objective: To delineate the effects of extracorporeal bypass on biomarkers of hemostasis, fibrinolysis, and inflammation and clinical sequelae. Methods: Patients were assigned prospectively and randomly to either on-pump (n=41) or off-pump (n=51) coronary bypass surgery. The concentrations of C-reactive protein (CRP), fibrinogen, D-dimer, and plasminogen act
Publicado em: 2010
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12. The effect of thyroid hormones on the white adipose tissue gene expression of PAI-1 and its serum concentration
Metabolic syndrome is associated with an increased risk of developing cardiovascular diseases and Plasminogen activator inhibitor 1 (PAI-1) overexpression may play a significant role in this process. A positive correlation between adipose tissue gene expression of PAI-1 and its serum concentration has been reported. Furthermore, high serum levels of thyroid
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-12