Platelet Aggregation Inhibitors Analysis
Mostrando 1-9 de 9 artigos, teses e dissertações.
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1. Purificação e caracterização biológica de uma nova serinoprotease com atividade trombina"like" do veneno total de Brothrops andianus (TLBan) / Purification and biological characterization of a new serine protease with thrombin "like" activity the whole venom of Brothrops andianus (TLBan)
In this word, a new serine protease with thrombin "like" activity the venom of Bothrops andianus (TLBan), snake of the Andes of Peru, was isolated by two steps: molecular exclusion chromatography G-75 and liquid chromatography in reversed-phase HPLC; with a high degree of purity and molecular homegenidade. Through of electrophoresis on SDS-PAGE shows the TLB
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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2. Análise proteômica das salivas dos triatomíneos Rhodnuis brethesi, Rhodnius robustus e Panstrongylus megistus, vetores da doença de Chagas
Triatomine bugs acting as vectors of Chagas‟ disease are haematophagous organisms in all of its evolvement phases. Their feeding success is greatly related to their salivary glands content. The presence of a pool of specific proteins allows this insect to access its food by counteracting host haemostatic mechanisms, such as platelet aggregation, clotti
Publicado em: 2009
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3. "Análise volumétrica da hiperplasia intimal intra-stent em pacientes diabéticos tratados com e sem abciximab" / Volumetric analysis of in-stent intimal hyperplasia in diabetic patients treated with or without abciximab
Ninety-six type 2 diabetics were randomly assigned to receive abciximab or no abciximab at the time of elective stent implantation to determine whether this IIb/IIIa glycoprotein inhibitor would reduce in-stent intimal hyperplasia, measured by intravascular ultrasound, at 6-month follow-up. Volumetric analysis showed that abciximab was not associated with a
Publicado em: 2004
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4. Estudo da trombose pulmonar causada pela peçonha da cascavel sul-americana (Crotalus durissus) e suas frações
Convulxin is a high molecular weight, non-enzymatic, platelet aggregating protein present in the venom of South American rattlesnake, Crotalus durissus terrificus. In this work, we investigatd the ability of convulxin to cause pulmonary thrombosis in mice after intravenous injection and examined the possible mechanism (s) involved using specific inhibitors.
Publicado em: 1999
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5. Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors.
The purification, complete amino acid sequence, and biological activity are described for several homologous snake venom proteins that are platelet glycoprotein (GP) IIb-IIIa antagonists and potent inhibitors of platelet aggregation. The primary structures of kistrin (from Agkistrodon rhodostoma), bitan (from Bitis arietans), three isoforms of trigramin (fro
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6. Human Platelet Collagenase
The presence of proteolytic enzymes such as cathepsin and elastase in platelets and the important role of collagen in platelet aggregation suggested that collagenase might be present in platelets. Epinephrine, ADP, and collagen liberate collagenase from platelets in plasma as measured by the hydrolysis of [14C]glycine-labeled collagen fibrils. The collagenas
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7. Selective Binding Site for [3H]Prostacyclin on Platelets
Prostacyclin (PGI2) is the most potent, naturally occurring inhibitor of platelet aggregation known. To determine whether PGI2 is bound by platelets, high specific activity [9-3H]PGI2 was synthesized by iodination and subsequent base treatment of the labeled precursor [9-3H]prostaglandin (PG)F2α methyl ester. Binding experiments were performed at room tempe
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8. Anti-thrombosis Repertoire of Blood-feeding Horsefly Salivary Glands*
Blood-feeding arthropods rely heavily on the pharmacological properties of their saliva to get a blood meal and suppress immune reactions of hosts. Little information is available on antihemostatic substances in horsefly salivary glands although their saliva has been thought to contain wide range of physiologically active molecules. In traditional Eastern me
The American Society for Biochemistry and Molecular Biology.
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9. A thrombin receptor function for platelet glycoprotein Ib–IX unmasked by cleavage of glycoprotein V
Glycoprotein (GP) V is a major substrate cleaved by the protease thrombin during thrombin-induced platelet activation. Previous analysis of platelets from GP V-null mice suggested a role for GP V as a negative modulator of platelet activation by thrombin. We now report the mechanism by which thrombin activates GP V −/− platelets. We show that proteo
The National Academy of Sciences.