Pre Clinical Administration
Mostrando 1-12 de 44 artigos, teses e dissertações.
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1. Reperfusion Strategies in Acute Myocardial Infarction: State of the Art
Abstract ST elevation myocardial infarction (STEMI) is a highly prevalent condition worldwide. Reperfusion therapy is strongly associated with the prognosis of STEMI and must be performed with a high standard of quality and without delay. A systematic review of different reperfusion strategies for STEMI was conducted, including randomized controlled trials t
International Journal of Cardiovascular Sciences. Publicado em: 2022
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2. Efficacy assessment of oral and sublingual sedation using alprazolam in implantology surgical procedures
RESUMO Objetivo: Avaliar a eficácia de duas formulações de alprazolam (ALP) na sedação de voluntários submetidos à procedimentos cirúrgicos de Implantodontia. Métodos: Foi realizado um estudo clinico, randomizado e cego, com 52 voluntários (ambos os gêneros) que foram divididos em 2 grupos: G1 (n=26) - administração de ALP (0,5mg) por via oral
RGO, Rev. Gaúch. Odontol.. Publicado em: 20/12/2019
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3. ANTIBIOTICS FOR APPENDICECTOMY IN CHILDREN AND ADOLESCENTS DURING THE PERIOPERATIVE PERIOD: AN INTEGRATIVE REVIEW
RESUMO Objetivo: Analisar o uso de antibióticos em crianças e adolescentes no perioperatório de apendicectomia. Fonte de dados: Realizou-se uma revisão integrativa, nas bases de dados MEDLINE, Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Cochrane e no portal PubMed, sem limite de tempo. As palavras-chave utilizadas foram:
Rev. paul. pediatr.. Publicado em: 04/07/2019
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4. Undergraduates performance on vaccine administration in simulated scenario
RESUMO Objetivo: Avaliar o desempenho de graduandos em Enfermagem sobre administração de vacinas no músculo vasto lateral da coxa em crianças como proposta de intervenção, utilizando cenário simulado, treino de habilidade e ambiente virtual de aprendizagem. Método: Pesquisa quantitativa, quase-experimental, pré e pós-teste, realizada com 39 estud
Rev. Bras. Enferm.. Publicado em: 18/04/2019
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5. Brown Flaxseed Prevents DNA Damage Induced by 1,2-Dimethylhydrazine in a Pre-Clinical Model
ABSTRACT The study evaluated the effects of brown flaxseed supplementation in natura on the prevention of DNA damage induced by 1,2-dimethylhydrazine (DMH) in vivo. The experimental groups were Negative and Positive Controls and the protocols of Pre-treatment, Simultaneous, Post-treatment, Pre+continuous in relation to the supplementation of brown flaxseed a
Braz. arch. biol. technol.. Publicado em: 14/11/2018
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6. Efficacy of stem cells on bone consolidation of distraction osteogenesis in animal models: a systematic review
Abstract Distraction osteogenesis (DO) relies on the recruitment and proliferation of mesenchymal stem cells (MSC) to the target site, where they differentiate into osteoblasts to promote bone formation. Nevertheless, MSC recruitment appears to be slow and limits bone formation in DO defects. Thus, this systematic review aims to evaluate the ability of local
Braz. oral res.. Publicado em: 14/11/2018
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7. High-Intensity Focused Ultrasound (HIFU) as salvage therapy for radio-recurrent prostate cancer: predictors of disease response
ABSTRACT Background Some men with localized radio-recurrent prostate cancer may benefit from salvage high-intensity focused ultrasound (HIFU). Herein, we describe oncologic outcomes and predictors of disease response after salvage whole gland HIFU from our prospective cohort. Materials and Methods Patients with localized radio-recurrent prostate cancer wer
Int. braz j urol.. Publicado em: 2018-04
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8. Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats
The abuse of psychoactive drugs is considered a global health problem. During the last years, a relevant number of studies have investigated the relationship between anabolic-androgenic steroids (AAS) and other psychoactive drugs. AAS, such as testosterone, can cause a dependence syndrome that shares many features with the classical dependence to psychoactiv
Braz J Med Biol Res. Publicado em: 17/11/2017
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9. Analgesia for patients undergoing shockwave lithotripsy for urinary stones – a systematic review and meta-analysis
ABSTRACT Background Shock wave lithotripsy (SWL) is the first line treatment modality for a significant proportion of patients with upper urinary tracts stones. Simple analgesics, opioids and non-steroidal anti-inflammatory drugs (NSAIDs) are all suitable agents but the relative efficacy and tolerability of these agents is uncertain. Objectives To determ
Int. braz j urol.. Publicado em: 2017-06
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10. In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats
ABSTRACT 6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in rats were studied. The permeability of 6MC was evaluated by t
Braz. J. Pharm. Sci.. Publicado em: 20/04/2017
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11. Evaluation of skin absorption of drugs from topical and transdermal formulations
ABSTRACT The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal f
Braz. J. Pharm. Sci.. Publicado em: 2016-09
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12. Effect of L-carnitine on exercise performance in patients with mitochondrial myopathy
Exercise intolerance due to impaired oxidative metabolism is a prominent symptom in patients with mitochondrial myopathy (MM), but it is still uncertain whether L-carnitine supplementation is beneficial for patients with MM. The aim of our study was to investigate the effects of L-carnitine on exercise performance in MM. Twelve MM subjects (mean age±SD=35.4
Braz J Med Biol Res. Publicado em: 24/02/2015